Macrophages in Homeostatic Immune Function
Macrophages are not only involved in inflammatory and anti-infective processes, but also play an important role in maintaining tissue homeostasis. In this review, we summarize recent evidence investigating the role of macrophages in controlling angiogenesis, metabolism and salt and water balance. Pa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00146/full |
| _version_ | 1811239518984994816 |
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| author | Jonathan eJantsch Katrina Jean Binger Dominik N N Muller Jens M Titze Jens M Titze |
| author_facet | Jonathan eJantsch Katrina Jean Binger Dominik N N Muller Jens M Titze Jens M Titze |
| author_sort | Jonathan eJantsch |
| collection | DOAJ |
| description | Macrophages are not only involved in inflammatory and anti-infective processes, but also play an important role in maintaining tissue homeostasis. In this review, we summarize recent evidence investigating the role of macrophages in controlling angiogenesis, metabolism and salt and water balance. Particularly, we summarize the importance of macrophage tonicity enhancer binding protein (TonEBP, also termed nuclear factor of activated T-cells 5 [NFAT5]) expression in the regulation of salt and water homeostasis. Further understanding of homeostatic macrophage function may lead to new therapeutic approaches to treat ischemia, hypertension and metabolic disorders. |
| first_indexed | 2024-04-12T13:01:19Z |
| format | Article |
| id | doaj.art-1b7256410ba34cffadd8dee9d9cd5cab |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T13:01:19Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-1b7256410ba34cffadd8dee9d9cd5cab2022-12-22T03:32:09ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2014-05-01510.3389/fphys.2014.0014682459Macrophages in Homeostatic Immune FunctionJonathan eJantsch0Katrina Jean Binger1Dominik N N Muller2Jens M Titze3Jens M Titze4Universitätsklinikum Erlangen und Friedrich-Alexander-Universität Erlangen-Nürnberg Max-Delbrück Center for Molecular Medicine, Charitè Campus Buch Max-Delbrück Center for Molecular Medicine, Charitè Campus BuchVanderbilt UniversityUniversitätsklinikum Erlangen und Friedrich-Alexander-Universität Erlangen-Nürnberg, ErlangenMacrophages are not only involved in inflammatory and anti-infective processes, but also play an important role in maintaining tissue homeostasis. In this review, we summarize recent evidence investigating the role of macrophages in controlling angiogenesis, metabolism and salt and water balance. Particularly, we summarize the importance of macrophage tonicity enhancer binding protein (TonEBP, also termed nuclear factor of activated T-cells 5 [NFAT5]) expression in the regulation of salt and water homeostasis. Further understanding of homeostatic macrophage function may lead to new therapeutic approaches to treat ischemia, hypertension and metabolic disorders.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00146/fullAdipose TissueHypertensionLipid MetabolismMacrophagesPeroxisome Proliferator-Activated ReceptorsSodium |
| spellingShingle | Jonathan eJantsch Katrina Jean Binger Dominik N N Muller Jens M Titze Jens M Titze Macrophages in Homeostatic Immune Function Frontiers in Physiology Adipose Tissue Hypertension Lipid Metabolism Macrophages Peroxisome Proliferator-Activated Receptors Sodium |
| title | Macrophages in Homeostatic Immune Function |
| title_full | Macrophages in Homeostatic Immune Function |
| title_fullStr | Macrophages in Homeostatic Immune Function |
| title_full_unstemmed | Macrophages in Homeostatic Immune Function |
| title_short | Macrophages in Homeostatic Immune Function |
| title_sort | macrophages in homeostatic immune function |
| topic | Adipose Tissue Hypertension Lipid Metabolism Macrophages Peroxisome Proliferator-Activated Receptors Sodium |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00146/full |
| work_keys_str_mv | AT jonathanejantsch macrophagesinhomeostaticimmunefunction AT katrinajeanbinger macrophagesinhomeostaticimmunefunction AT dominiknnmuller macrophagesinhomeostaticimmunefunction AT jensmtitze macrophagesinhomeostaticimmunefunction AT jensmtitze macrophagesinhomeostaticimmunefunction |