| Summary: | Gastric ulcers are commonly seen in the upper gastrointestinal tract and may be related to the <i>Helicobacter pylori</i> infection and the use of aspirin, a nonsteroidal anti-inflammatory drug (NSAID). Typically, proton-pump inhibitors (PPIs) are used to treat gastric ulcers; however, adverse effects have emerged following long-term treatment. Natural medicines are used as alternative therapeutic agents in the treatment of gastric ulcers, with few side effects. Despite various reports on the anti-<i>H. pylori</i> and anti-gastric cancer activities of <i>Anisomeles indica</i>, its gastroprotective effect on ulcers remains undetermined. This study investigated the protective effect of <i>A. indica</i> on aspirin-induced gastric ulcers in murine models. Our results show that three fractions of ethanol-extracted <i>A. indica</i> inhibited aspirin-induced gastric injury. Among these, <i>A. indica</i> Fraction 1 was observed to enrich ovatodiolide, which effectively diminished gastric acidity and alleviated aspirin-induced inflammation in the stomach. Our results provide evidence that <i>A. indica</i> could be developed as an effective therapeutic agent for gastroprotective purposes.
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