Gastroprotective Effect of <i>Anisomeles indica</i> on Aspirin-Induced Gastric Ulcer in Mice
Gastric ulcers are commonly seen in the upper gastrointestinal tract and may be related to the <i>Helicobacter pylori</i> infection and the use of aspirin, a nonsteroidal anti-inflammatory drug (NSAID). Typically, proton-pump inhibitors (PPIs) are used to treat gastric ulcers; however, a...
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MDPI AG
2022-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/12/2327 |
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| author | Hsiu-Man Lien Yu-Yen Wang Mei-Zi Huang Hui-Yu Wu Chao-Lu Huang Chia-Chi Chen Shao-Wen Hung Chia-Chang Chen Cheng-Hsun Chiu Chih-Ho Lai |
| author_facet | Hsiu-Man Lien Yu-Yen Wang Mei-Zi Huang Hui-Yu Wu Chao-Lu Huang Chia-Chi Chen Shao-Wen Hung Chia-Chang Chen Cheng-Hsun Chiu Chih-Ho Lai |
| author_sort | Hsiu-Man Lien |
| collection | DOAJ |
| description | Gastric ulcers are commonly seen in the upper gastrointestinal tract and may be related to the <i>Helicobacter pylori</i> infection and the use of aspirin, a nonsteroidal anti-inflammatory drug (NSAID). Typically, proton-pump inhibitors (PPIs) are used to treat gastric ulcers; however, adverse effects have emerged following long-term treatment. Natural medicines are used as alternative therapeutic agents in the treatment of gastric ulcers, with few side effects. Despite various reports on the anti-<i>H. pylori</i> and anti-gastric cancer activities of <i>Anisomeles indica</i>, its gastroprotective effect on ulcers remains undetermined. This study investigated the protective effect of <i>A. indica</i> on aspirin-induced gastric ulcers in murine models. Our results show that three fractions of ethanol-extracted <i>A. indica</i> inhibited aspirin-induced gastric injury. Among these, <i>A. indica</i> Fraction 1 was observed to enrich ovatodiolide, which effectively diminished gastric acidity and alleviated aspirin-induced inflammation in the stomach. Our results provide evidence that <i>A. indica</i> could be developed as an effective therapeutic agent for gastroprotective purposes. |
| first_indexed | 2024-03-09T17:23:44Z |
| format | Article |
| id | doaj.art-1b738904c69b44a093d9cd4b19a723c8 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T17:23:44Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-1b738904c69b44a093d9cd4b19a723c82023-11-24T12:56:09ZengMDPI AGAntioxidants2076-39212022-11-011112232710.3390/antiox11122327Gastroprotective Effect of <i>Anisomeles indica</i> on Aspirin-Induced Gastric Ulcer in MiceHsiu-Man Lien0Yu-Yen Wang1Mei-Zi Huang2Hui-Yu Wu3Chao-Lu Huang4Chia-Chi Chen5Shao-Wen Hung6Chia-Chang Chen7Cheng-Hsun Chiu8Chih-Ho Lai9Research Institute of Biotechnology, Hungkuang University, Taichung 433304, TaiwanDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Life Sciences, National Chung Hsing University, Taichung 40227, TaiwanAnimal Technology Research Center, Agricultural Technology Research Institute, Hsinchu 300110, TaiwanAnimal Technology Research Center, Agricultural Technology Research Institute, Hsinchu 300110, TaiwanSchool of Management, Feng Chia University, Taichung 407102, TaiwanDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, TaiwanGastric ulcers are commonly seen in the upper gastrointestinal tract and may be related to the <i>Helicobacter pylori</i> infection and the use of aspirin, a nonsteroidal anti-inflammatory drug (NSAID). Typically, proton-pump inhibitors (PPIs) are used to treat gastric ulcers; however, adverse effects have emerged following long-term treatment. Natural medicines are used as alternative therapeutic agents in the treatment of gastric ulcers, with few side effects. Despite various reports on the anti-<i>H. pylori</i> and anti-gastric cancer activities of <i>Anisomeles indica</i>, its gastroprotective effect on ulcers remains undetermined. This study investigated the protective effect of <i>A. indica</i> on aspirin-induced gastric ulcers in murine models. Our results show that three fractions of ethanol-extracted <i>A. indica</i> inhibited aspirin-induced gastric injury. Among these, <i>A. indica</i> Fraction 1 was observed to enrich ovatodiolide, which effectively diminished gastric acidity and alleviated aspirin-induced inflammation in the stomach. Our results provide evidence that <i>A. indica</i> could be developed as an effective therapeutic agent for gastroprotective purposes.https://www.mdpi.com/2076-3921/11/12/2327<i>Anisomeles indica</i>ovatodiolideaspiringastric ulcerinflammation |
| spellingShingle | Hsiu-Man Lien Yu-Yen Wang Mei-Zi Huang Hui-Yu Wu Chao-Lu Huang Chia-Chi Chen Shao-Wen Hung Chia-Chang Chen Cheng-Hsun Chiu Chih-Ho Lai Gastroprotective Effect of <i>Anisomeles indica</i> on Aspirin-Induced Gastric Ulcer in Mice Antioxidants <i>Anisomeles indica</i> ovatodiolide aspirin gastric ulcer inflammation |
| title | Gastroprotective Effect of <i>Anisomeles indica</i> on Aspirin-Induced Gastric Ulcer in Mice |
| title_full | Gastroprotective Effect of <i>Anisomeles indica</i> on Aspirin-Induced Gastric Ulcer in Mice |
| title_fullStr | Gastroprotective Effect of <i>Anisomeles indica</i> on Aspirin-Induced Gastric Ulcer in Mice |
| title_full_unstemmed | Gastroprotective Effect of <i>Anisomeles indica</i> on Aspirin-Induced Gastric Ulcer in Mice |
| title_short | Gastroprotective Effect of <i>Anisomeles indica</i> on Aspirin-Induced Gastric Ulcer in Mice |
| title_sort | gastroprotective effect of i anisomeles indica i on aspirin induced gastric ulcer in mice |
| topic | <i>Anisomeles indica</i> ovatodiolide aspirin gastric ulcer inflammation |
| url | https://www.mdpi.com/2076-3921/11/12/2327 |
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