Association between Fibrinogen-to-Albumin Ratio and Prognosis in Patients Admitted to an Intensive Care Unit
The objective of this study was to investigate the usefulness of fibrinogen-to-albumin ratio (FAR) as a prognostic marker in patients admitted to an intensive care unit (ICU) compared with Sequential Organ Failure Assessment (SOFA) score, a widely used prognostic scoring system. An inverse probabili...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/4/1407 |
| _version_ | 1797620178329010176 |
|---|---|
| author | Keun-Soo Kim Ah-Ran Oh Jungchan Park Jeong-Am Ryu |
| author_facet | Keun-Soo Kim Ah-Ran Oh Jungchan Park Jeong-Am Ryu |
| author_sort | Keun-Soo Kim |
| collection | DOAJ |
| description | The objective of this study was to investigate the usefulness of fibrinogen-to-albumin ratio (FAR) as a prognostic marker in patients admitted to an intensive care unit (ICU) compared with Sequential Organ Failure Assessment (SOFA) score, a widely used prognostic scoring system. An inverse probability weighting (IPW) was used to control for selection bias and confounding factors. After IPW adjustment, the high FAR group showed significantly higher risk of 1-year compared with low FAR group (36.4% vs. 12.4%, adjust hazard ratio = 1.72; 95% confidence interval (CI): 1.59–1.86; <i>p</i> < 0.001). In the receiver-operating characteristic curve analysis associated with the prediction of 1-year mortality, there was no significant difference between the area under the curve of FAR on ICU admission (C-statistic: 0.684, 95% CI: 0.673–0.694) and that of SOFA score on ICU admission (C-statistic: 0.679, 95% CI: 0.669–0.688) (<i>p</i> = 0.532). In this study, FAR and SOFA score at ICU admission were associated with 1-year mortality in patients admitted to an ICU. Especially, FAR was easier to obtain in critically ill patients than SOFA score. Therefore, FAR is feasible and might help predict long-term mortality in these patients. |
| first_indexed | 2024-03-11T08:38:24Z |
| format | Article |
| id | doaj.art-1b745e4c2e1446babba12977042fd4eb |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:38:24Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1b745e4c2e1446babba12977042fd4eb2023-11-16T21:19:07ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124140710.3390/jcm12041407Association between Fibrinogen-to-Albumin Ratio and Prognosis in Patients Admitted to an Intensive Care UnitKeun-Soo Kim0Ah-Ran Oh1Jungchan Park2Jeong-Am Ryu3Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaThe objective of this study was to investigate the usefulness of fibrinogen-to-albumin ratio (FAR) as a prognostic marker in patients admitted to an intensive care unit (ICU) compared with Sequential Organ Failure Assessment (SOFA) score, a widely used prognostic scoring system. An inverse probability weighting (IPW) was used to control for selection bias and confounding factors. After IPW adjustment, the high FAR group showed significantly higher risk of 1-year compared with low FAR group (36.4% vs. 12.4%, adjust hazard ratio = 1.72; 95% confidence interval (CI): 1.59–1.86; <i>p</i> < 0.001). In the receiver-operating characteristic curve analysis associated with the prediction of 1-year mortality, there was no significant difference between the area under the curve of FAR on ICU admission (C-statistic: 0.684, 95% CI: 0.673–0.694) and that of SOFA score on ICU admission (C-statistic: 0.679, 95% CI: 0.669–0.688) (<i>p</i> = 0.532). In this study, FAR and SOFA score at ICU admission were associated with 1-year mortality in patients admitted to an ICU. Especially, FAR was easier to obtain in critically ill patients than SOFA score. Therefore, FAR is feasible and might help predict long-term mortality in these patients.https://www.mdpi.com/2077-0383/12/4/1407fibrinogenalbuminSOFA scoreprognosisintensive care unit |
| spellingShingle | Keun-Soo Kim Ah-Ran Oh Jungchan Park Jeong-Am Ryu Association between Fibrinogen-to-Albumin Ratio and Prognosis in Patients Admitted to an Intensive Care Unit Journal of Clinical Medicine fibrinogen albumin SOFA score prognosis intensive care unit |
| title | Association between Fibrinogen-to-Albumin Ratio and Prognosis in Patients Admitted to an Intensive Care Unit |
| title_full | Association between Fibrinogen-to-Albumin Ratio and Prognosis in Patients Admitted to an Intensive Care Unit |
| title_fullStr | Association between Fibrinogen-to-Albumin Ratio and Prognosis in Patients Admitted to an Intensive Care Unit |
| title_full_unstemmed | Association between Fibrinogen-to-Albumin Ratio and Prognosis in Patients Admitted to an Intensive Care Unit |
| title_short | Association between Fibrinogen-to-Albumin Ratio and Prognosis in Patients Admitted to an Intensive Care Unit |
| title_sort | association between fibrinogen to albumin ratio and prognosis in patients admitted to an intensive care unit |
| topic | fibrinogen albumin SOFA score prognosis intensive care unit |
| url | https://www.mdpi.com/2077-0383/12/4/1407 |
| work_keys_str_mv | AT keunsookim associationbetweenfibrinogentoalbuminratioandprognosisinpatientsadmittedtoanintensivecareunit AT ahranoh associationbetweenfibrinogentoalbuminratioandprognosisinpatientsadmittedtoanintensivecareunit AT jungchanpark associationbetweenfibrinogentoalbuminratioandprognosisinpatientsadmittedtoanintensivecareunit AT jeongamryu associationbetweenfibrinogentoalbuminratioandprognosisinpatientsadmittedtoanintensivecareunit |