Emergence of Nasal Carriage of ST80 and ST152 PVL+ Staphylococcus aureus Isolates from Livestock in Algeria
The spread of toxinogenic Staphylococcus aureus is a public health problem in Africa. The objectives of the study were to investigate the rate of S. aureus nasal carriage and molecular characteristics of these strains in livestock and humans in three Algerian provinces. Nasal samples were collected...
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MDPI AG
2017-09-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/9/10/303 |
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| author | Amir Agabou Zouleikha Ouchenane Christelle Ngba Essebe Salim Khemissi Mohamed Tedj Eddine Chehboub Ilyes Bey Chehboub Albert Sotto Catherine Dunyach-Remy Jean-Philippe Lavigne |
| author_facet | Amir Agabou Zouleikha Ouchenane Christelle Ngba Essebe Salim Khemissi Mohamed Tedj Eddine Chehboub Ilyes Bey Chehboub Albert Sotto Catherine Dunyach-Remy Jean-Philippe Lavigne |
| author_sort | Amir Agabou |
| collection | DOAJ |
| description | The spread of toxinogenic Staphylococcus aureus is a public health problem in Africa. The objectives of the study were to investigate the rate of S. aureus nasal carriage and molecular characteristics of these strains in livestock and humans in three Algerian provinces. Nasal samples were collected from camels, horses, cattle, sheep and monkeys, as well as humans in contact with them. S. aureus isolates were genotyped using DNA microarray. The rate of S. aureus nasal carriage varied between species: camels (53%), humans and monkeys (50%), sheep (44.2%), horses (15.2%) and cattle (15%). Nine methicillin-resistant S. aureus (MRSA) isolates (7.6%) were identified, isolated from camels and sheep. The S. aureus isolates belonged to 15 different clonal complexes. Among them, PVL+ (Panton–Valentine Leukocidin) isolates belonging to ST80-MRSA-IV and ST152-MSSA were identified in camels (n = 3, 13%) and sheep (n = 4, 21.1%). A high prevalence of toxinogenic animal strains was noted containing TSST-1- (22.2%), EDINB- (29.6%) and EtD- (11.1%) encoding genes. This study showed the dispersal of the highly human pathogenic clones ST152-MSSA and ST-80-MRSA in animals. It suggests the ability of some clones to cross the species barrier and jump between humans and several animal species. |
| first_indexed | 2024-04-11T12:47:09Z |
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| language | English |
| last_indexed | 2024-04-11T12:47:09Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-1b788a9f9d524fa59e8e9159732582252022-12-22T04:23:19ZengMDPI AGToxins2072-66512017-09-0191030310.3390/toxins9100303toxins9100303Emergence of Nasal Carriage of ST80 and ST152 PVL+ Staphylococcus aureus Isolates from Livestock in AlgeriaAmir Agabou0Zouleikha Ouchenane1Christelle Ngba Essebe2Salim Khemissi3Mohamed Tedj Eddine Chehboub4Ilyes Bey Chehboub5Albert Sotto6Catherine Dunyach-Remy7Jean-Philippe Lavigne8Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier, UFR de Médecine, 30908 Nîmes, FranceLaboratoire de microbiologie, Hôpital Militaire Régional Universitaire de Constantine, Constantine 25001, AlgérieInstitut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier, UFR de Médecine, 30908 Nîmes, FranceLaboratoire de microbiologie, Hôpital Militaire Régional Universitaire de Constantine, Constantine 25001, AlgérieLaboratoire PADESCA, Institut des Sciences Vétérinaires, Université des Frères Mentouri-Constantine 1, Constantine 25017, AlgérieLaboratoire PADESCA, Institut des Sciences Vétérinaires, Université des Frères Mentouri-Constantine 1, Constantine 25017, AlgérieInstitut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier, UFR de Médecine, 30908 Nîmes, FranceInstitut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier, UFR de Médecine, 30908 Nîmes, FranceInstitut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier, UFR de Médecine, 30908 Nîmes, FranceThe spread of toxinogenic Staphylococcus aureus is a public health problem in Africa. The objectives of the study were to investigate the rate of S. aureus nasal carriage and molecular characteristics of these strains in livestock and humans in three Algerian provinces. Nasal samples were collected from camels, horses, cattle, sheep and monkeys, as well as humans in contact with them. S. aureus isolates were genotyped using DNA microarray. The rate of S. aureus nasal carriage varied between species: camels (53%), humans and monkeys (50%), sheep (44.2%), horses (15.2%) and cattle (15%). Nine methicillin-resistant S. aureus (MRSA) isolates (7.6%) were identified, isolated from camels and sheep. The S. aureus isolates belonged to 15 different clonal complexes. Among them, PVL+ (Panton–Valentine Leukocidin) isolates belonging to ST80-MRSA-IV and ST152-MSSA were identified in camels (n = 3, 13%) and sheep (n = 4, 21.1%). A high prevalence of toxinogenic animal strains was noted containing TSST-1- (22.2%), EDINB- (29.6%) and EtD- (11.1%) encoding genes. This study showed the dispersal of the highly human pathogenic clones ST152-MSSA and ST-80-MRSA in animals. It suggests the ability of some clones to cross the species barrier and jump between humans and several animal species.https://www.mdpi.com/2072-6651/9/10/303Algeriaclonal complexMRSAMSSAnasal carriagePanton–Valentine LeukocidinStaphylococcus aureusST80ST152 |
| spellingShingle | Amir Agabou Zouleikha Ouchenane Christelle Ngba Essebe Salim Khemissi Mohamed Tedj Eddine Chehboub Ilyes Bey Chehboub Albert Sotto Catherine Dunyach-Remy Jean-Philippe Lavigne Emergence of Nasal Carriage of ST80 and ST152 PVL+ Staphylococcus aureus Isolates from Livestock in Algeria Toxins Algeria clonal complex MRSA MSSA nasal carriage Panton–Valentine Leukocidin Staphylococcus aureus ST80 ST152 |
| title | Emergence of Nasal Carriage of ST80 and ST152 PVL+ Staphylococcus aureus Isolates from Livestock in Algeria |
| title_full | Emergence of Nasal Carriage of ST80 and ST152 PVL+ Staphylococcus aureus Isolates from Livestock in Algeria |
| title_fullStr | Emergence of Nasal Carriage of ST80 and ST152 PVL+ Staphylococcus aureus Isolates from Livestock in Algeria |
| title_full_unstemmed | Emergence of Nasal Carriage of ST80 and ST152 PVL+ Staphylococcus aureus Isolates from Livestock in Algeria |
| title_short | Emergence of Nasal Carriage of ST80 and ST152 PVL+ Staphylococcus aureus Isolates from Livestock in Algeria |
| title_sort | emergence of nasal carriage of st80 and st152 pvl staphylococcus aureus isolates from livestock in algeria |
| topic | Algeria clonal complex MRSA MSSA nasal carriage Panton–Valentine Leukocidin Staphylococcus aureus ST80 ST152 |
| url | https://www.mdpi.com/2072-6651/9/10/303 |
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