A Rare Case of Association between Pseudohypoparathyroidism and Type 1 Diabetes Mellitus
Background and Objective: Type 1 diabetes mellitus (T1DM) as an autoimmune disease is associated with hyperglycemia and pseudohypoparathyroidism with hypoglycemia. In this study, we report a rare case of association between type 1 diabetes and pseudohypoparathyroidism. Case Report: A 12.5-year-old f...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2023-03-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| Subjects: | |
| Online Access: | http://jbums.org/article-1-10807-en.pdf |
| _version_ | 1797374890780655616 |
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| author | SH Hashemi M Motadel M Alijanpour |
| author_facet | SH Hashemi M Motadel M Alijanpour |
| author_sort | SH Hashemi |
| collection | DOAJ |
| description | Background and Objective: Type 1 diabetes mellitus (T1DM) as an autoimmune disease is associated with hyperglycemia and pseudohypoparathyroidism with hypoglycemia. In this study, we report a rare case of association between type 1 diabetes and pseudohypoparathyroidism.
Case Report: A 12.5-year-old female patient with a one-month history of polyuria and polydipsia was admitted with severe lethargy and vomiting, and due to high blood sugar and metabolic acidosis, Diabetic Ketoacidosis (DKA) was diagnosed. She was first treated with DKA protocol and then Basal- Bolus Protocol of insulin. The patient had a history of seizures due to hypocalcemia at the ages of 8 days and 2 months. In re-examination during hospitalization due to hypocalcemia-hyperphosphatemia and high parathyroid hormone, the diagnosis of false hypoparathyroidism was proposed and treatment with oral calcium tablet and calcitriol capsule was done and she was discharged after seven days with a good general condition.
Conclusion: In patients with pseudohypoparathyroidism, in the event of a disturbance in glucose status, the pattern is usually hypoglycemia, but in our patient, this association was in the form of hyperglycemia and DKA in the context of T1DM, which is an indication of the rare association of these two diseases. Therefore, one should think about early diagnosis and proper treatment of this rare association. |
| first_indexed | 2024-03-08T19:12:18Z |
| format | Article |
| id | doaj.art-1b79391d6c314e9490fce9e316e16df1 |
| institution | Directory Open Access Journal |
| issn | 1561-4107 2251-7170 |
| language | English |
| last_indexed | 2024-03-08T19:12:18Z |
| publishDate | 2023-03-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj.art-1b79391d6c314e9490fce9e316e16df12023-12-27T10:07:40ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702023-03-01251102107A Rare Case of Association between Pseudohypoparathyroidism and Type 1 Diabetes MellitusSH Hashemi0M Motadel1M Alijanpour2 1. Student Research Committee, Babol University of Medical Sciences, Babol, I.R.Iran. 2.The Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, I.R.Iran. 3.Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. Background and Objective: Type 1 diabetes mellitus (T1DM) as an autoimmune disease is associated with hyperglycemia and pseudohypoparathyroidism with hypoglycemia. In this study, we report a rare case of association between type 1 diabetes and pseudohypoparathyroidism. Case Report: A 12.5-year-old female patient with a one-month history of polyuria and polydipsia was admitted with severe lethargy and vomiting, and due to high blood sugar and metabolic acidosis, Diabetic Ketoacidosis (DKA) was diagnosed. She was first treated with DKA protocol and then Basal- Bolus Protocol of insulin. The patient had a history of seizures due to hypocalcemia at the ages of 8 days and 2 months. In re-examination during hospitalization due to hypocalcemia-hyperphosphatemia and high parathyroid hormone, the diagnosis of false hypoparathyroidism was proposed and treatment with oral calcium tablet and calcitriol capsule was done and she was discharged after seven days with a good general condition. Conclusion: In patients with pseudohypoparathyroidism, in the event of a disturbance in glucose status, the pattern is usually hypoglycemia, but in our patient, this association was in the form of hyperglycemia and DKA in the context of T1DM, which is an indication of the rare association of these two diseases. Therefore, one should think about early diagnosis and proper treatment of this rare association.http://jbums.org/article-1-10807-en.pdfpseudohypoparathyroidismtype 1 diabetes mellitushypocalcemiaparathyroid hormone. |
| spellingShingle | SH Hashemi M Motadel M Alijanpour A Rare Case of Association between Pseudohypoparathyroidism and Type 1 Diabetes Mellitus Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul pseudohypoparathyroidism type 1 diabetes mellitus hypocalcemia parathyroid hormone. |
| title | A Rare Case of Association between Pseudohypoparathyroidism and Type 1 Diabetes Mellitus |
| title_full | A Rare Case of Association between Pseudohypoparathyroidism and Type 1 Diabetes Mellitus |
| title_fullStr | A Rare Case of Association between Pseudohypoparathyroidism and Type 1 Diabetes Mellitus |
| title_full_unstemmed | A Rare Case of Association between Pseudohypoparathyroidism and Type 1 Diabetes Mellitus |
| title_short | A Rare Case of Association between Pseudohypoparathyroidism and Type 1 Diabetes Mellitus |
| title_sort | rare case of association between pseudohypoparathyroidism and type 1 diabetes mellitus |
| topic | pseudohypoparathyroidism type 1 diabetes mellitus hypocalcemia parathyroid hormone. |
| url | http://jbums.org/article-1-10807-en.pdf |
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