Patterns and factors associated with pneumococcal vaccination in a prospective cohort of 1,697 patients with rheumatoid arthritis
IntroductionPatients with rheumatoid arthritis (RA) are at increased risk for serious infections. Pneumococcal vaccination is among the most important preventive measures, however, vaccine uptake is suboptimal. We explored the rate and factors associated with pneumococcal vaccination in a contempora...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-01-01
|
Series: | Frontiers in Medicine |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1039464/full |
_version_ | 1797957440761757696 |
---|---|
author | Konstantinos Thomas Argyro Lazarini Evripidis Kaltsonoudis Paraskevi V. Voulgari Alexandros A. Drosos Argyro Repa Ainour Molla Ismail Sali Prodromos Sidiropoulos Panagiota Tsatsani Sousana Gazi Kalliopi Fragkiadaki Maria G. Tektonidou Petros P. Sfikakis Pelagia Katsimbri Dimitrios Boumpas Evangelia Argyriou Kyriaki A. Boki Konstantina Karagianni Christina Katsiari Gerasimos Evangelatos Alexios Iliopoulos Eleftheria P. Grika Panagiotis G. Vlachoyiannopoulos Theodoros Dimitroulas Alexandros Garyfallos Konstantinos Melissaropoulos Panagiotis Georgiou Constantinos Georganas Periklis Vounotrypidis Konstantinos Ntelis Maria Areti George D. Kitas George D. Kitas Dimitrios Vassilopoulos |
author_facet | Konstantinos Thomas Argyro Lazarini Evripidis Kaltsonoudis Paraskevi V. Voulgari Alexandros A. Drosos Argyro Repa Ainour Molla Ismail Sali Prodromos Sidiropoulos Panagiota Tsatsani Sousana Gazi Kalliopi Fragkiadaki Maria G. Tektonidou Petros P. Sfikakis Pelagia Katsimbri Dimitrios Boumpas Evangelia Argyriou Kyriaki A. Boki Konstantina Karagianni Christina Katsiari Gerasimos Evangelatos Alexios Iliopoulos Eleftheria P. Grika Panagiotis G. Vlachoyiannopoulos Theodoros Dimitroulas Alexandros Garyfallos Konstantinos Melissaropoulos Panagiotis Georgiou Constantinos Georganas Periklis Vounotrypidis Konstantinos Ntelis Maria Areti George D. Kitas George D. Kitas Dimitrios Vassilopoulos |
author_sort | Konstantinos Thomas |
collection | DOAJ |
description | IntroductionPatients with rheumatoid arthritis (RA) are at increased risk for serious infections. Pneumococcal vaccination is among the most important preventive measures, however, vaccine uptake is suboptimal. We explored the rate and factors associated with pneumococcal vaccination in a contemporary RA cohort.Materials and methodsMulti-center, prospective, RA cohort study in Greece. Patient and disease characteristics and influenza and pneumococcal vaccinations were documented at baseline and 3 years later.ResultsOne thousand six hundred and ninety-seven patients were included and 34.5% had already received at least one pneumococcal vaccine at baseline. Among 1,111 non-vaccinated patients, 40.1% received pneumococcal vaccination during follow-up, increasing the vaccine coverage to 60.8%. By multivariate analysis, positive predictors for pneumococcal vaccination included prescription of influenza vaccine (OR = 33.35, 95% CI: 18.58–59.85), history of cancer (OR = 2.35, 95% CI: 1.09–5.06), bDMARD use (OR = 1.85, 95% CI: 1.29–2.65), seropositivity (OR = 1.47, 95% CI: 1.05–2.05), and high disease activity (DAS28-ESR, OR = 1.33, 95% CI: 1.17–1.51). Male sex (OR = 0.65, 95% CI: 0.43–0.99) was a negative predictor for pneumococcal vaccination during follow-up.DiscussionDespite increasing rates of pneumococcal vaccine coverage, 40% of RA patients remain unvaccinated. Severe disease, bDMARD use, comorbidities, and more importantly flu vaccination were the most significant factors associated with pneumococcal vaccination, emphasizing the currently unmet need for cultivating a “vaccination culture” in RA patients. |
first_indexed | 2024-04-11T00:05:07Z |
format | Article |
id | doaj.art-1b7a518de5de4e53badc589265562105 |
institution | Directory Open Access Journal |
issn | 2296-858X |
language | English |
last_indexed | 2024-04-11T00:05:07Z |
publishDate | 2023-01-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Medicine |
spelling | doaj.art-1b7a518de5de4e53badc5892655621052023-01-09T11:58:37ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-01-01910.3389/fmed.2022.10394641039464Patterns and factors associated with pneumococcal vaccination in a prospective cohort of 1,697 patients with rheumatoid arthritisKonstantinos Thomas0Argyro Lazarini1Evripidis Kaltsonoudis2Paraskevi V. Voulgari3Alexandros A. Drosos4Argyro Repa5Ainour Molla Ismail Sali6Prodromos Sidiropoulos7Panagiota Tsatsani8Sousana Gazi9Kalliopi Fragkiadaki10Maria G. Tektonidou11Petros P. Sfikakis12Pelagia Katsimbri13Dimitrios Boumpas14Evangelia Argyriou15Kyriaki A. Boki16Konstantina Karagianni17Christina Katsiari18Gerasimos Evangelatos19Alexios Iliopoulos20Eleftheria P. Grika21Panagiotis G. Vlachoyiannopoulos22Theodoros Dimitroulas23Alexandros Garyfallos24Konstantinos Melissaropoulos25Panagiotis Georgiou26Constantinos Georganas27Periklis Vounotrypidis28Konstantinos Ntelis29Maria Areti30George D. Kitas31George D. Kitas32Dimitrios Vassilopoulos33Joint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceJoint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceRheumatology Clinic, University of Ioannina, Ioannina, GreeceRheumatology Clinic, University of Ioannina, Ioannina, GreeceRheumatology Clinic, University of Ioannina, Ioannina, GreeceDepartment of Clinical Immunology and Allergy, University of Crete, Heraklion, GreeceDepartment of Clinical Immunology and Allergy, University of Crete, Heraklion, GreeceDepartment of Clinical Immunology and Allergy, University of Crete, Heraklion, GreeceRheumatology Unit, KAT Hospital, Athens, GreeceRheumatology Unit, KAT Hospital, Athens, GreeceJoint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceJoint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceJoint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceJoint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceJoint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceRheumatology Unit, Sismanoglio Hospital, Athens, GreeceRheumatology Unit, Sismanoglio Hospital, Athens, GreeceDepartment of Rheumatology, University of Thessaly, Larissa, GreeceDepartment of Rheumatology, University of Thessaly, Larissa, GreeceRheumatology Unit, NIMTS Hospital, Athens, GreeceRheumatology Unit, NIMTS Hospital, Athens, GreeceJoint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceJoint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece4th Department of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece4th Department of Medicine, Aristotle University of Thessaloniki, Thessaloniki, GreeceRheumatology Unit, Agios Andreas Hospital, Patras, GreeceRheumatology Unit, Agios Andreas Hospital, Patras, Greece0Private Practitioner, Athens, Greece1Private Practitioner, Thessaloniki, Greece2Private Practitioner, Kalamata, Greece3Private Practitioner, Leivadia, GreeceJoint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece4Hygeia Hospital, Athens, GreeceJoint Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceIntroductionPatients with rheumatoid arthritis (RA) are at increased risk for serious infections. Pneumococcal vaccination is among the most important preventive measures, however, vaccine uptake is suboptimal. We explored the rate and factors associated with pneumococcal vaccination in a contemporary RA cohort.Materials and methodsMulti-center, prospective, RA cohort study in Greece. Patient and disease characteristics and influenza and pneumococcal vaccinations were documented at baseline and 3 years later.ResultsOne thousand six hundred and ninety-seven patients were included and 34.5% had already received at least one pneumococcal vaccine at baseline. Among 1,111 non-vaccinated patients, 40.1% received pneumococcal vaccination during follow-up, increasing the vaccine coverage to 60.8%. By multivariate analysis, positive predictors for pneumococcal vaccination included prescription of influenza vaccine (OR = 33.35, 95% CI: 18.58–59.85), history of cancer (OR = 2.35, 95% CI: 1.09–5.06), bDMARD use (OR = 1.85, 95% CI: 1.29–2.65), seropositivity (OR = 1.47, 95% CI: 1.05–2.05), and high disease activity (DAS28-ESR, OR = 1.33, 95% CI: 1.17–1.51). Male sex (OR = 0.65, 95% CI: 0.43–0.99) was a negative predictor for pneumococcal vaccination during follow-up.DiscussionDespite increasing rates of pneumococcal vaccine coverage, 40% of RA patients remain unvaccinated. Severe disease, bDMARD use, comorbidities, and more importantly flu vaccination were the most significant factors associated with pneumococcal vaccination, emphasizing the currently unmet need for cultivating a “vaccination culture” in RA patients.https://www.frontiersin.org/articles/10.3389/fmed.2022.1039464/fullrheumatoid arthritisvaccinationbiological therapyinfectionscomorbidities |
spellingShingle | Konstantinos Thomas Argyro Lazarini Evripidis Kaltsonoudis Paraskevi V. Voulgari Alexandros A. Drosos Argyro Repa Ainour Molla Ismail Sali Prodromos Sidiropoulos Panagiota Tsatsani Sousana Gazi Kalliopi Fragkiadaki Maria G. Tektonidou Petros P. Sfikakis Pelagia Katsimbri Dimitrios Boumpas Evangelia Argyriou Kyriaki A. Boki Konstantina Karagianni Christina Katsiari Gerasimos Evangelatos Alexios Iliopoulos Eleftheria P. Grika Panagiotis G. Vlachoyiannopoulos Theodoros Dimitroulas Alexandros Garyfallos Konstantinos Melissaropoulos Panagiotis Georgiou Constantinos Georganas Periklis Vounotrypidis Konstantinos Ntelis Maria Areti George D. Kitas George D. Kitas Dimitrios Vassilopoulos Patterns and factors associated with pneumococcal vaccination in a prospective cohort of 1,697 patients with rheumatoid arthritis Frontiers in Medicine rheumatoid arthritis vaccination biological therapy infections comorbidities |
title | Patterns and factors associated with pneumococcal vaccination in a prospective cohort of 1,697 patients with rheumatoid arthritis |
title_full | Patterns and factors associated with pneumococcal vaccination in a prospective cohort of 1,697 patients with rheumatoid arthritis |
title_fullStr | Patterns and factors associated with pneumococcal vaccination in a prospective cohort of 1,697 patients with rheumatoid arthritis |
title_full_unstemmed | Patterns and factors associated with pneumococcal vaccination in a prospective cohort of 1,697 patients with rheumatoid arthritis |
title_short | Patterns and factors associated with pneumococcal vaccination in a prospective cohort of 1,697 patients with rheumatoid arthritis |
title_sort | patterns and factors associated with pneumococcal vaccination in a prospective cohort of 1 697 patients with rheumatoid arthritis |
topic | rheumatoid arthritis vaccination biological therapy infections comorbidities |
url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1039464/full |
work_keys_str_mv | AT konstantinosthomas patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT argyrolazarini patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT evripidiskaltsonoudis patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT paraskevivvoulgari patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT alexandrosadrosos patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT argyrorepa patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT ainourmollaismailsali patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT prodromossidiropoulos patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT panagiotatsatsani patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT sousanagazi patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT kalliopifragkiadaki patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT mariagtektonidou patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT petrospsfikakis patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT pelagiakatsimbri patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT dimitriosboumpas patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT evangeliaargyriou patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT kyriakiaboki patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT konstantinakaragianni patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT christinakatsiari patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT gerasimosevangelatos patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT alexiosiliopoulos patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT eleftheriapgrika patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT panagiotisgvlachoyiannopoulos patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT theodorosdimitroulas patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT alexandrosgaryfallos patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT konstantinosmelissaropoulos patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT panagiotisgeorgiou patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT constantinosgeorganas patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT periklisvounotrypidis patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT konstantinosntelis patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT mariaareti patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT georgedkitas patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT georgedkitas patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis AT dimitriosvassilopoulos patternsandfactorsassociatedwithpneumococcalvaccinationinaprospectivecohortof1697patientswithrheumatoidarthritis |