A neuropathologic feature of brain aging: multi-lumen vascular profiles
Abstract Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs), which are characterized by multiple vessel lumens enclosed in a single vascular channel. Little information exists on the prevalence, risk facto...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Acta Neuropathologica Communications |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40478-023-01638-2 |
| _version_ | 1797555788533727232 |
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| author | Eseosa T. Ighodaro Ryan K. Shahidehpour Adam D. Bachstetter Erin L. Abner Ruth S. Nelson David W. Fardo Andy Y. Shih Roger I. Grant Janna H. Neltner Frederick A. Schmitt Gregory A. Jicha Richard J. Kryscio Donna M. Wilcock Linda J. Van Eldik Peter T. Nelson |
| author_facet | Eseosa T. Ighodaro Ryan K. Shahidehpour Adam D. Bachstetter Erin L. Abner Ruth S. Nelson David W. Fardo Andy Y. Shih Roger I. Grant Janna H. Neltner Frederick A. Schmitt Gregory A. Jicha Richard J. Kryscio Donna M. Wilcock Linda J. Van Eldik Peter T. Nelson |
| author_sort | Eseosa T. Ighodaro |
| collection | DOAJ |
| description | Abstract Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs), which are characterized by multiple vessel lumens enclosed in a single vascular channel. Little information exists on the prevalence, risk factors, and co-pathologies of MVPs. Therefore, we used samples and data from the University of Kentucky Alzheimer’s Disease Research Center (n = 91), the University of Kentucky Pathology Department (n = 31), and the University of Pittsburgh Pathology Department (n = 4) to study MVPs. Age at death was correlated with MVP density in the frontal neocortex, Brodmann Area 9 (r = 0.51; p < 0.0001). Exploratory analyses were performed to evaluate the association between conventional vascular risk factors (e.g., hypertension, diabetes), cardiovascular diseases (e.g., heart attack, arrhythmia), and cerebrovascular disease (e.g., stroke); the only nominal association with MVP density was a self-reported history of brain trauma (Prevalence Ratio = 2.1; 95 CI 1.1–3.9, before correcting for multiple comparisons). No specific associations were detected between neuropathological (e.g., brain arteriolosclerosis) or genetic (e.g., APOE) variables and MVP density. Using a tissue clearing method called SeeDB, we provide 3-dimensional images of MVPs in brain tissue. We conclude that MVPs are an age-related brain pathology and more work is required to identify their clinical-pathological correlation and associated risk factors. |
| first_indexed | 2024-03-10T16:52:40Z |
| format | Article |
| id | doaj.art-1b7a8921bec849f2afb0d08e63ee89b6 |
| institution | Directory Open Access Journal |
| issn | 2051-5960 |
| language | English |
| last_indexed | 2024-03-10T16:52:40Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Acta Neuropathologica Communications |
| spelling | doaj.art-1b7a8921bec849f2afb0d08e63ee89b62023-11-20T11:15:08ZengBMCActa Neuropathologica Communications2051-59602023-08-0111111510.1186/s40478-023-01638-2A neuropathologic feature of brain aging: multi-lumen vascular profilesEseosa T. Ighodaro0Ryan K. Shahidehpour1Adam D. Bachstetter2Erin L. Abner3Ruth S. Nelson4David W. Fardo5Andy Y. Shih6Roger I. Grant7Janna H. Neltner8Frederick A. Schmitt9Gregory A. Jicha10Richard J. Kryscio11Donna M. Wilcock12Linda J. Van Eldik13Peter T. Nelson14Department of Neurology, Emory UniversitySanders-Brown Center On Aging, University of KentuckySanders-Brown Center On Aging, University of KentuckySanders-Brown Center On Aging, University of KentuckyEmory UniversitySanders-Brown Center On Aging, University of KentuckyDepartment of Pediatrics, Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, University of WashingtonDepartment of Neurosciences and Center for Biomedical Imaging, Medical University of South CarolinaDepartment of Pathology and Laboratory Medicine, Division of Neuropathology, University of KentuckySanders-Brown Center On Aging, University of KentuckySanders-Brown Center On Aging, University of KentuckySanders-Brown Center On Aging, University of KentuckySanders-Brown Center On Aging, University of KentuckySanders-Brown Center On Aging, University of KentuckySanders-Brown Center On Aging, University of KentuckyAbstract Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs), which are characterized by multiple vessel lumens enclosed in a single vascular channel. Little information exists on the prevalence, risk factors, and co-pathologies of MVPs. Therefore, we used samples and data from the University of Kentucky Alzheimer’s Disease Research Center (n = 91), the University of Kentucky Pathology Department (n = 31), and the University of Pittsburgh Pathology Department (n = 4) to study MVPs. Age at death was correlated with MVP density in the frontal neocortex, Brodmann Area 9 (r = 0.51; p < 0.0001). Exploratory analyses were performed to evaluate the association between conventional vascular risk factors (e.g., hypertension, diabetes), cardiovascular diseases (e.g., heart attack, arrhythmia), and cerebrovascular disease (e.g., stroke); the only nominal association with MVP density was a self-reported history of brain trauma (Prevalence Ratio = 2.1; 95 CI 1.1–3.9, before correcting for multiple comparisons). No specific associations were detected between neuropathological (e.g., brain arteriolosclerosis) or genetic (e.g., APOE) variables and MVP density. Using a tissue clearing method called SeeDB, we provide 3-dimensional images of MVPs in brain tissue. We conclude that MVPs are an age-related brain pathology and more work is required to identify their clinical-pathological correlation and associated risk factors.https://doi.org/10.1186/s40478-023-01638-2VCIDSmall vessel diseaseSVDTBIVTESenescence |
| spellingShingle | Eseosa T. Ighodaro Ryan K. Shahidehpour Adam D. Bachstetter Erin L. Abner Ruth S. Nelson David W. Fardo Andy Y. Shih Roger I. Grant Janna H. Neltner Frederick A. Schmitt Gregory A. Jicha Richard J. Kryscio Donna M. Wilcock Linda J. Van Eldik Peter T. Nelson A neuropathologic feature of brain aging: multi-lumen vascular profiles Acta Neuropathologica Communications VCID Small vessel disease SVD TBI VTE Senescence |
| title | A neuropathologic feature of brain aging: multi-lumen vascular profiles |
| title_full | A neuropathologic feature of brain aging: multi-lumen vascular profiles |
| title_fullStr | A neuropathologic feature of brain aging: multi-lumen vascular profiles |
| title_full_unstemmed | A neuropathologic feature of brain aging: multi-lumen vascular profiles |
| title_short | A neuropathologic feature of brain aging: multi-lumen vascular profiles |
| title_sort | neuropathologic feature of brain aging multi lumen vascular profiles |
| topic | VCID Small vessel disease SVD TBI VTE Senescence |
| url | https://doi.org/10.1186/s40478-023-01638-2 |
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