Protective Role of Nrf2 in Renal Disease
Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. However, therapies to slow or prevent CKD progression remain an unmet need. Nrf2...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/1/39 |
| _version_ | 1797542789905383424 |
|---|---|
| author | Melania Guerrero-Hue Sandra Rayego-Mateos Cristina Vázquez-Carballo Alejandra Palomino-Antolín Cristina García-Caballero Lucas Opazo-Rios José Luis Morgado-Pascual Carmen Herencia Sebastián Mas Alberto Ortiz Alfonso Rubio-Navarro Javier Egea José Manuel Villalba Jesús Egido Juan Antonio Moreno |
| author_facet | Melania Guerrero-Hue Sandra Rayego-Mateos Cristina Vázquez-Carballo Alejandra Palomino-Antolín Cristina García-Caballero Lucas Opazo-Rios José Luis Morgado-Pascual Carmen Herencia Sebastián Mas Alberto Ortiz Alfonso Rubio-Navarro Javier Egea José Manuel Villalba Jesús Egido Juan Antonio Moreno |
| author_sort | Melania Guerrero-Hue |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. However, therapies to slow or prevent CKD progression remain an unmet need. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that plays a key role in protection against oxidative stress and regulation of the inflammatory response. Consequently, the use of compounds targeting Nrf2 has generated growing interest for nephrologists. Pre-clinical and clinical studies have demonstrated that Nrf2-inducing strategies prevent CKD progression and protect from acute kidney injury (AKI). In this article, we review current knowledge on the protective mechanisms mediated by Nrf2 against kidney injury, novel therapeutic strategies to induce Nrf2 activation, and the status of ongoing clinical trials targeting Nrf2 in renal diseases. |
| first_indexed | 2024-03-10T13:35:31Z |
| format | Article |
| id | doaj.art-1b7bfe55885f4191b65646457b3e8d96 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T13:35:31Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-1b7bfe55885f4191b65646457b3e8d962023-11-21T07:30:29ZengMDPI AGAntioxidants2076-39212020-12-011013910.3390/antiox10010039Protective Role of Nrf2 in Renal DiseaseMelania Guerrero-Hue0Sandra Rayego-Mateos1Cristina Vázquez-Carballo2Alejandra Palomino-Antolín3Cristina García-Caballero4Lucas Opazo-Rios5José Luis Morgado-Pascual6Carmen Herencia7Sebastián Mas8Alberto Ortiz9Alfonso Rubio-Navarro10Javier Egea11José Manuel Villalba12Jesús Egido13Juan Antonio Moreno14Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, SpainMaimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, SpainInstituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Autónoma University, 28040 Madrid, SpainResearch Unit, Hospital Universitario Santa Cristina, IIS-Hospital Universitario de la Princesa, 28006 Madrid, SpainMaimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, SpainInstituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Autónoma University, 28040 Madrid, SpainMaimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, SpainInstituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Autónoma University, 28040 Madrid, SpainInstituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Autónoma University, 28040 Madrid, SpainInstituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Autónoma University, 28040 Madrid, SpainWeill Center for Metabolic Health and Division of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USAResearch Unit, Hospital Universitario Santa Cristina, IIS-Hospital Universitario de la Princesa, 28006 Madrid, SpainDepartment of Cell Biology, Physiology, and Immunology, Agrifood Campus of International Excellence (ceiA3), University of Cordoba, 14014 Cordoba, SpainInstituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Autónoma University, 28040 Madrid, SpainMaimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, SpainChronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. However, therapies to slow or prevent CKD progression remain an unmet need. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that plays a key role in protection against oxidative stress and regulation of the inflammatory response. Consequently, the use of compounds targeting Nrf2 has generated growing interest for nephrologists. Pre-clinical and clinical studies have demonstrated that Nrf2-inducing strategies prevent CKD progression and protect from acute kidney injury (AKI). In this article, we review current knowledge on the protective mechanisms mediated by Nrf2 against kidney injury, novel therapeutic strategies to induce Nrf2 activation, and the status of ongoing clinical trials targeting Nrf2 in renal diseases.https://www.mdpi.com/2076-3921/10/1/39Nrf2renal diseaseacute kidney injuryoxidative stressand inflammatory response |
| spellingShingle | Melania Guerrero-Hue Sandra Rayego-Mateos Cristina Vázquez-Carballo Alejandra Palomino-Antolín Cristina García-Caballero Lucas Opazo-Rios José Luis Morgado-Pascual Carmen Herencia Sebastián Mas Alberto Ortiz Alfonso Rubio-Navarro Javier Egea José Manuel Villalba Jesús Egido Juan Antonio Moreno Protective Role of Nrf2 in Renal Disease Antioxidants Nrf2 renal disease acute kidney injury oxidative stress and inflammatory response |
| title | Protective Role of Nrf2 in Renal Disease |
| title_full | Protective Role of Nrf2 in Renal Disease |
| title_fullStr | Protective Role of Nrf2 in Renal Disease |
| title_full_unstemmed | Protective Role of Nrf2 in Renal Disease |
| title_short | Protective Role of Nrf2 in Renal Disease |
| title_sort | protective role of nrf2 in renal disease |
| topic | Nrf2 renal disease acute kidney injury oxidative stress and inflammatory response |
| url | https://www.mdpi.com/2076-3921/10/1/39 |
| work_keys_str_mv | AT melaniaguerrerohue protectiveroleofnrf2inrenaldisease AT sandrarayegomateos protectiveroleofnrf2inrenaldisease AT cristinavazquezcarballo protectiveroleofnrf2inrenaldisease AT alejandrapalominoantolin protectiveroleofnrf2inrenaldisease AT cristinagarciacaballero protectiveroleofnrf2inrenaldisease AT lucasopazorios protectiveroleofnrf2inrenaldisease AT joseluismorgadopascual protectiveroleofnrf2inrenaldisease AT carmenherencia protectiveroleofnrf2inrenaldisease AT sebastianmas protectiveroleofnrf2inrenaldisease AT albertoortiz protectiveroleofnrf2inrenaldisease AT alfonsorubionavarro protectiveroleofnrf2inrenaldisease AT javieregea protectiveroleofnrf2inrenaldisease AT josemanuelvillalba protectiveroleofnrf2inrenaldisease AT jesusegido protectiveroleofnrf2inrenaldisease AT juanantoniomoreno protectiveroleofnrf2inrenaldisease |