Modulatory Effects of Autophagy on APP Processing as a Potential Treatment Target for Alzheimer’s Disease

Modulatory Effects of Autophagy on APP Processing as a Potential Treatment Target for Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized by the formation of intracellular aggregate composed of heavily phosphorylated tau protein and extracellular deposit of amyloid-β (Aβ) plaques derived from proteolysis cleavage of amyloid precursor protein (APP). Autophagy refers to the lysosomal-mediated de...

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Bibliographic Details
Main Authors: Md. Ataur Rahman, Md Saidur Rahman, MD. Hasanur Rahman, Mohammad Rasheduzzaman, ANM Mamun-Or-Rashid, Md Jamal Uddin, Md Rezanur Rahman, Hongik Hwang, Myung-Geol Pang, Hyewhon Rhim
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomedicines
Subjects:
autophagy
amyloid precursor protein (APP)
β-amyloid (Aβ)
mTOR
Alzheimer’s disease (AD)
Online Access:https://www.mdpi.com/2227-9059/9/1/5

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