| Summary: | Isoamyl (<i>E</i>)-3-(3,4-dimethoxyphenyl)acrylate (<b>1</b>) was obtained from the 2-methyl-6-nitrobenzoic anhydride (MNBA)/4-dimethylaminopyridine (DMAP)-catalyzed reaction at room temperature for 190 min in dichloromethane with a yield of 95%. The structure of isoamyl (<i>E</i>)-3-(3,4-dimethoxyphenyl)acrylate (<b>1</b>) was elucidated using NMR, FTIR, and high-resolution mass spectrometry. In vitro sun protection factor evaluation exhibited a value of 37.10 ± 0.03 which indicates that isoamyl (<i>E</i>)-3-(3,4-dimethoxyphenyl)acrylate (<b>1</b>) is a sunscreen agent with high protection.
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