Auditory Event-Related Potentials in Antipsychotic-Free Subjects With Ultra-High-Risk State and First-Episode Psychosis
Background: Auditory event-related potentials (ERPs) have been utilized to study defective information processing of patients with schizophrenia. To delineate the pathophysiological processes from pre-psychotic state to first-episode psychosis, a study on subjects from ultra-high-risk (UHR) state to...
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00223/full |
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| author | Ming H. Hsieh Ming H. Hsieh Ming H. Hsieh Yi-Ting Lin Yi-Ting Lin Yi-Ling Chien Yi-Ling Chien Tzung-Jeng Hwang Tzung-Jeng Hwang Tzung-Jeng Hwang Hai-Gwo Hwu Hai-Gwo Hwu Hai-Gwo Hwu Chih-Min Liu Chih-Min Liu Chih-Min Liu Chen-Chung Liu Chen-Chung Liu |
| author_facet | Ming H. Hsieh Ming H. Hsieh Ming H. Hsieh Yi-Ting Lin Yi-Ting Lin Yi-Ling Chien Yi-Ling Chien Tzung-Jeng Hwang Tzung-Jeng Hwang Tzung-Jeng Hwang Hai-Gwo Hwu Hai-Gwo Hwu Hai-Gwo Hwu Chih-Min Liu Chih-Min Liu Chih-Min Liu Chen-Chung Liu Chen-Chung Liu |
| author_sort | Ming H. Hsieh |
| collection | DOAJ |
| description | Background: Auditory event-related potentials (ERPs) have been utilized to study defective information processing of patients with schizophrenia. To delineate the pathophysiological processes from pre-psychotic state to first-episode psychosis, a study on subjects from ultra-high-risk (UHR) state to first-episode psychosis, ideally in an antipsychotic-free condition, can add important information to our understanding.Methods: Patients with UHR state or at their first-episode psychosis (FEP) who were drug-naive or only have been temporarily treated with antipsychotics were assessed by auditory ERPs measurement, including P50/N100 (sensory gating) and duration mismatch negativity (MMN; deviance detection). A group of age-matched healthy subjects served as their controls.Results: A total of 42 patients (23 UHR and 19 FEP) and 120 control subjects were recruited, including 21 pure drug-naive and 21 with very short exposure to antipsychotics. Collapsing FEP and UHR as a patient group, they exhibited significant sensory deficits manifested as larger P50 S2 amplitude, larger N100 ratio, and smaller N100 difference, and significantly less deviance detection response revealed by MMN. Such differences were less significant when treating FEP and UHR separately for comparisons. Comparisons of ERP results between drug-naive subjects and antipsychotic-short-exposure subjects revealed no significant difference in any P50/N100 and MMN parameter.Conclusion: Our study is one of the few studies focused on drug-naive or minimally treated patients at pre- or early-psychotic states. Our results exhibited impaired performance in sensory gating and deviance detection shown by certain parameters. A longitudinal study with larger sample sizes will be helpful to provide more evidence to elucidate the role of antipsychotics on an individual’s neurophysiological performance at different stages of psychosis. |
| first_indexed | 2024-12-20T18:01:09Z |
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| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-20T18:01:09Z |
| publishDate | 2019-04-01 |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-1b7d1391f0e6462393b9010b7f6712fa2022-12-21T19:30:38ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-04-011010.3389/fpsyt.2019.00223443040Auditory Event-Related Potentials in Antipsychotic-Free Subjects With Ultra-High-Risk State and First-Episode PsychosisMing H. Hsieh0Ming H. Hsieh1Ming H. Hsieh2Yi-Ting Lin3Yi-Ting Lin4Yi-Ling Chien5Yi-Ling Chien6Tzung-Jeng Hwang7Tzung-Jeng Hwang8Tzung-Jeng Hwang9Hai-Gwo Hwu10Hai-Gwo Hwu11Hai-Gwo Hwu12Chih-Min Liu13Chih-Min Liu14Chih-Min Liu15Chen-Chung Liu16Chen-Chung Liu17Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, TaiwanDepartment of Psychiatry, College of Medicine, National Taiwan University, Taipei, TaiwanGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, TaiwanDepartment of Psychiatry, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, TaiwanDepartment of Psychiatry, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, TaiwanDepartment of Psychiatry, College of Medicine, National Taiwan University, Taipei, TaiwanGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, TaiwanDepartment of Psychiatry, College of Medicine, National Taiwan University, Taipei, TaiwanGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, TaiwanDepartment of Psychiatry, College of Medicine, National Taiwan University, Taipei, TaiwanGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, TaiwanDepartment of Psychiatry, College of Medicine, National Taiwan University, Taipei, TaiwanBackground: Auditory event-related potentials (ERPs) have been utilized to study defective information processing of patients with schizophrenia. To delineate the pathophysiological processes from pre-psychotic state to first-episode psychosis, a study on subjects from ultra-high-risk (UHR) state to first-episode psychosis, ideally in an antipsychotic-free condition, can add important information to our understanding.Methods: Patients with UHR state or at their first-episode psychosis (FEP) who were drug-naive or only have been temporarily treated with antipsychotics were assessed by auditory ERPs measurement, including P50/N100 (sensory gating) and duration mismatch negativity (MMN; deviance detection). A group of age-matched healthy subjects served as their controls.Results: A total of 42 patients (23 UHR and 19 FEP) and 120 control subjects were recruited, including 21 pure drug-naive and 21 with very short exposure to antipsychotics. Collapsing FEP and UHR as a patient group, they exhibited significant sensory deficits manifested as larger P50 S2 amplitude, larger N100 ratio, and smaller N100 difference, and significantly less deviance detection response revealed by MMN. Such differences were less significant when treating FEP and UHR separately for comparisons. Comparisons of ERP results between drug-naive subjects and antipsychotic-short-exposure subjects revealed no significant difference in any P50/N100 and MMN parameter.Conclusion: Our study is one of the few studies focused on drug-naive or minimally treated patients at pre- or early-psychotic states. Our results exhibited impaired performance in sensory gating and deviance detection shown by certain parameters. A longitudinal study with larger sample sizes will be helpful to provide more evidence to elucidate the role of antipsychotics on an individual’s neurophysiological performance at different stages of psychosis.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00223/fullevent-related potentialsfirst-episode psychosismismatch negativityN100P50schizophrenia |
| spellingShingle | Ming H. Hsieh Ming H. Hsieh Ming H. Hsieh Yi-Ting Lin Yi-Ting Lin Yi-Ling Chien Yi-Ling Chien Tzung-Jeng Hwang Tzung-Jeng Hwang Tzung-Jeng Hwang Hai-Gwo Hwu Hai-Gwo Hwu Hai-Gwo Hwu Chih-Min Liu Chih-Min Liu Chih-Min Liu Chen-Chung Liu Chen-Chung Liu Auditory Event-Related Potentials in Antipsychotic-Free Subjects With Ultra-High-Risk State and First-Episode Psychosis Frontiers in Psychiatry event-related potentials first-episode psychosis mismatch negativity N100 P50 schizophrenia |
| title | Auditory Event-Related Potentials in Antipsychotic-Free Subjects With Ultra-High-Risk State and First-Episode Psychosis |
| title_full | Auditory Event-Related Potentials in Antipsychotic-Free Subjects With Ultra-High-Risk State and First-Episode Psychosis |
| title_fullStr | Auditory Event-Related Potentials in Antipsychotic-Free Subjects With Ultra-High-Risk State and First-Episode Psychosis |
| title_full_unstemmed | Auditory Event-Related Potentials in Antipsychotic-Free Subjects With Ultra-High-Risk State and First-Episode Psychosis |
| title_short | Auditory Event-Related Potentials in Antipsychotic-Free Subjects With Ultra-High-Risk State and First-Episode Psychosis |
| title_sort | auditory event related potentials in antipsychotic free subjects with ultra high risk state and first episode psychosis |
| topic | event-related potentials first-episode psychosis mismatch negativity N100 P50 schizophrenia |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00223/full |
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