The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt.

The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt.

The Notch pathway plays a vital role in determining whether cells in the intestinal epithelium adopt a secretory or an absorptive phenotype. Cell fate specification is coordinated via Notch's interaction with the canonical Wnt pathway. Here, we propose a new mathematical model of the Notch and...

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Detaylı Bibliyografya
Asıl Yazarlar: Sophie K Kay, Heather A Harrington, Sarah Shepherd, Keith Brennan, Trevor Dale, James M Osborne, David J Gavaghan, Helen M Byrne
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Public Library of Science (PLoS) 2017-02-01
Seri Bilgileri:PLoS Computational Biology
Online Erişim:http://europepmc.org/articles/PMC5363986?pdf=render

Internet

http://europepmc.org/articles/PMC5363986?pdf=render

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