Characterization of Polysaccharides with Antioxidant and Hepatoprotective Activities from the Edible Mushroom Oudemansiella radicata
The preliminary structure, in vitro antioxidant and in vivo hepatoprotective activities of water-soluble polysaccharides (ORWP) and alkali-soluble polysaccharides (ORAP), prepared from the mushroom Oudemansiella radicata, were investigated. Both ORWP and ORAP were heteropolysaccharides with mannose,...
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MDPI AG
2017-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/22/2/234 |
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| author | Qin Liu Mengjuan Zhu Xueran Geng Hexiang Wang Tzi Bun Ng |
| author_facet | Qin Liu Mengjuan Zhu Xueran Geng Hexiang Wang Tzi Bun Ng |
| author_sort | Qin Liu |
| collection | DOAJ |
| description | The preliminary structure, in vitro antioxidant and in vivo hepatoprotective activities of water-soluble polysaccharides (ORWP) and alkali-soluble polysaccharides (ORAP), prepared from the mushroom Oudemansiella radicata, were investigated. Both ORWP and ORAP were heteropolysaccharides with mannose, glucose and galactose being the main monosaccharide components. Regarding the antioxidant activities, ORWP and ORAP showed effective 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, hydrogen peroxide scavenging activity and lipid peroxidation inhibitory effects, as well as moderate reducing power and Fe2+ chelating activity. For the hepatoprotective activity, administration of ORWP and ORAP prevented the increase in serum alanine aminotransferase and aspartate aminotransferase activities in a carbon tetrachloride-induced acute liver damage model, suppressed hepatic malondialdehyde formation and stimulated the activities of hepatic superoxide dismutase and glutathione peroxidase. Thus, we speculate that ORWP and ORAP may protect the liver from CCl4-induced hepatic damage via antioxidant mechanisms. |
| first_indexed | 2024-12-11T21:30:03Z |
| format | Article |
| id | doaj.art-1b7e9e9e17ac4ee9b382b0b3fb39ee6c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T21:30:03Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj.art-1b7e9e9e17ac4ee9b382b0b3fb39ee6c2022-12-22T00:50:12ZengMDPI AGMolecules1420-30492017-02-0122223410.3390/molecules22020234molecules22020234Characterization of Polysaccharides with Antioxidant and Hepatoprotective Activities from the Edible Mushroom Oudemansiella radicataQin Liu0Mengjuan Zhu1Xueran Geng2Hexiang Wang3Tzi Bun Ng4Institute of Plant Nutrition, Agricultural Resources and Environmental Science, Henan Academy of Agricultural Sciences, Zhengzhou 450002, ChinaDepartment of Fungal Resource, College of Plant Protection, Shandong Agricultural University, Tai’an 271018, ChinaCollege of Food Science and Engineering, Shanxi Agricultural University, Taigu 030801, ChinaState Key Laboratory for Agrobiotechnology, Department of Microbiology, China Agricultural University, Beijing 100193, ChinaSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, ChinaThe preliminary structure, in vitro antioxidant and in vivo hepatoprotective activities of water-soluble polysaccharides (ORWP) and alkali-soluble polysaccharides (ORAP), prepared from the mushroom Oudemansiella radicata, were investigated. Both ORWP and ORAP were heteropolysaccharides with mannose, glucose and galactose being the main monosaccharide components. Regarding the antioxidant activities, ORWP and ORAP showed effective 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, hydrogen peroxide scavenging activity and lipid peroxidation inhibitory effects, as well as moderate reducing power and Fe2+ chelating activity. For the hepatoprotective activity, administration of ORWP and ORAP prevented the increase in serum alanine aminotransferase and aspartate aminotransferase activities in a carbon tetrachloride-induced acute liver damage model, suppressed hepatic malondialdehyde formation and stimulated the activities of hepatic superoxide dismutase and glutathione peroxidase. Thus, we speculate that ORWP and ORAP may protect the liver from CCl4-induced hepatic damage via antioxidant mechanisms.http://www.mdpi.com/1420-3049/22/2/234antioxidanthepatoprotectiveOudemansiella radicatapolysaccharides |
| spellingShingle | Qin Liu Mengjuan Zhu Xueran Geng Hexiang Wang Tzi Bun Ng Characterization of Polysaccharides with Antioxidant and Hepatoprotective Activities from the Edible Mushroom Oudemansiella radicata Molecules antioxidant hepatoprotective Oudemansiella radicata polysaccharides |
| title | Characterization of Polysaccharides with Antioxidant and Hepatoprotective Activities from the Edible Mushroom Oudemansiella radicata |
| title_full | Characterization of Polysaccharides with Antioxidant and Hepatoprotective Activities from the Edible Mushroom Oudemansiella radicata |
| title_fullStr | Characterization of Polysaccharides with Antioxidant and Hepatoprotective Activities from the Edible Mushroom Oudemansiella radicata |
| title_full_unstemmed | Characterization of Polysaccharides with Antioxidant and Hepatoprotective Activities from the Edible Mushroom Oudemansiella radicata |
| title_short | Characterization of Polysaccharides with Antioxidant and Hepatoprotective Activities from the Edible Mushroom Oudemansiella radicata |
| title_sort | characterization of polysaccharides with antioxidant and hepatoprotective activities from the edible mushroom oudemansiella radicata |
| topic | antioxidant hepatoprotective Oudemansiella radicata polysaccharides |
| url | http://www.mdpi.com/1420-3049/22/2/234 |
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