Evaluation of Ischemia-Modified Albumin and C-Reactive Protein in Type 2 Diabetics with and without Ketosis
Overview To investigate whether serum ischemia-modified albumin or C-reactive protein is reliable for predicting type 2 diabetic patients with ketosis. Approach One hundred and four diabetic patients, 48 with diabetic ketosis, and 33 controls were enrolled in the study. Serum ischemia-modified album...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2012-01-01
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| Series: | Biomarker Insights |
| Online Access: | https://doi.org/10.4137/BMI.S9060 |
| _version_ | 1819013799267532800 |
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| author | Shao-gang Ma Yao Jin Wen Hu Feng Bai Wen Xu Wei-nan Yu |
| author_facet | Shao-gang Ma Yao Jin Wen Hu Feng Bai Wen Xu Wei-nan Yu |
| author_sort | Shao-gang Ma |
| collection | DOAJ |
| description | Overview To investigate whether serum ischemia-modified albumin or C-reactive protein is reliable for predicting type 2 diabetic patients with ketosis. Approach One hundred and four diabetic patients, 48 with diabetic ketosis, and 33 controls were enrolled in the study. Serum ischemia-modified albumin and C-reactive protein were measured and evaluated for their ability to distinguish diabetic ketosis. Results Compared to the controls, the ischemia-modified albumin and C-reactive protein levels were higher in patients with diabetic ketosis and type 2 diabetes at the baseline. The levels of ischemia-modified albumin were higher in patients with type 2 diabetes than in the controls. C-reactive protein and ischemia-modified albumin levels were reduced after insulin treatment. The level of ischemia-modified albumin was an independent risk marker for diabetic ketosis ( OR = 1.085, P = 0.008, 95% CI: 1.022–1.152). Receiver operating characteristic curves revealed that the areas under the curve were 0.917 for the modified albumin and 0.357 for C-reactive protein. Conclusion This study indicates that ischemia-modified albumin was significantly associated with diabetic ketosis and was more sensitive than C-reactive protein in reflecting diabetic ketosis. |
| first_indexed | 2024-12-21T02:05:41Z |
| format | Article |
| id | doaj.art-1b8077111cdd4cffa2a680c78592ce9b |
| institution | Directory Open Access Journal |
| issn | 1177-2719 |
| language | English |
| last_indexed | 2024-12-21T02:05:41Z |
| publishDate | 2012-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomarker Insights |
| spelling | doaj.art-1b8077111cdd4cffa2a680c78592ce9b2022-12-21T19:19:29ZengSAGE PublishingBiomarker Insights1177-27192012-01-01710.4137/BMI.S9060Evaluation of Ischemia-Modified Albumin and C-Reactive Protein in Type 2 Diabetics with and without KetosisShao-gang Ma0Yao Jin1Wen Hu2Feng Bai3Wen Xu4Wei-nan Yu5Department of Endocrinology and Metabolism, the Affiliated Huai'an Hospital of Xuzhou Medical College.Department of Clinical Laboratory, the Affiliated Huai'an Hospital of Xuzhou Medical College.Department of Endocrinology and Metabolism, the Affiliated Huai'an Hospital of Xuzhou Medical College.Department of Endocrinology and Metabolism, the Affiliated Huai'an Hospital of Xuzhou Medical College.Department of Endocrinology and Metabolism, the Affiliated Huai'an Hospital of Xuzhou Medical College.Department of Endocrinology and Metabolism, the Affiliated Huai'an Hospital of Xuzhou Medical College.Overview To investigate whether serum ischemia-modified albumin or C-reactive protein is reliable for predicting type 2 diabetic patients with ketosis. Approach One hundred and four diabetic patients, 48 with diabetic ketosis, and 33 controls were enrolled in the study. Serum ischemia-modified albumin and C-reactive protein were measured and evaluated for their ability to distinguish diabetic ketosis. Results Compared to the controls, the ischemia-modified albumin and C-reactive protein levels were higher in patients with diabetic ketosis and type 2 diabetes at the baseline. The levels of ischemia-modified albumin were higher in patients with type 2 diabetes than in the controls. C-reactive protein and ischemia-modified albumin levels were reduced after insulin treatment. The level of ischemia-modified albumin was an independent risk marker for diabetic ketosis ( OR = 1.085, P = 0.008, 95% CI: 1.022–1.152). Receiver operating characteristic curves revealed that the areas under the curve were 0.917 for the modified albumin and 0.357 for C-reactive protein. Conclusion This study indicates that ischemia-modified albumin was significantly associated with diabetic ketosis and was more sensitive than C-reactive protein in reflecting diabetic ketosis.https://doi.org/10.4137/BMI.S9060 |
| spellingShingle | Shao-gang Ma Yao Jin Wen Hu Feng Bai Wen Xu Wei-nan Yu Evaluation of Ischemia-Modified Albumin and C-Reactive Protein in Type 2 Diabetics with and without Ketosis Biomarker Insights |
| title | Evaluation of Ischemia-Modified Albumin and C-Reactive Protein in Type 2 Diabetics with and without Ketosis |
| title_full | Evaluation of Ischemia-Modified Albumin and C-Reactive Protein in Type 2 Diabetics with and without Ketosis |
| title_fullStr | Evaluation of Ischemia-Modified Albumin and C-Reactive Protein in Type 2 Diabetics with and without Ketosis |
| title_full_unstemmed | Evaluation of Ischemia-Modified Albumin and C-Reactive Protein in Type 2 Diabetics with and without Ketosis |
| title_short | Evaluation of Ischemia-Modified Albumin and C-Reactive Protein in Type 2 Diabetics with and without Ketosis |
| title_sort | evaluation of ischemia modified albumin and c reactive protein in type 2 diabetics with and without ketosis |
| url | https://doi.org/10.4137/BMI.S9060 |
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