Wine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cells
Dietary antioxidants such as phenolic phytochemicals may prevent/improve endothelial function impairment observed in cardiovascular diseases. This study investigates the specific protective effects of a vegetal seasoning obtained from seedless wine pomace against hyperglycaemia-induced oxidative dam...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-04-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464616000554 |
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| author | Raquel Del Pino-García Gisela Gerardi María D. Rivero-Pérez María L. González-SanJosé Javier García-Lomillo Pilar Muñiz |
| author_facet | Raquel Del Pino-García Gisela Gerardi María D. Rivero-Pérez María L. González-SanJosé Javier García-Lomillo Pilar Muñiz |
| author_sort | Raquel Del Pino-García |
| collection | DOAJ |
| description | Dietary antioxidants such as phenolic phytochemicals may prevent/improve endothelial function impairment observed in cardiovascular diseases. This study investigates the specific protective effects of a vegetal seasoning obtained from seedless wine pomace against hyperglycaemia-induced oxidative damage and dysfunction in human umbilical vein endothelial cells EA.hy926. Non-cytotoxic doses of the bioactive compounds obtained following in vitro digestion of the seasoning were used as treatments. Digested compounds, especially colonic bacterial metabolites, restored a more balanced redox environment, prevented lipid peroxidation and cell membrane damage, ameliorated protein oxidation, and improved the balance between endothelial reactive oxygen species and nitric oxide production in hyperglycaemic cells. Reduction of angiotensin I-converting enzyme activity and gene modulation of superoxide dismutase, haem oxygenase-1, β-nicotinamide adenine dinucleotide phosphate oxidase-4, and endothelial nitric oxide synthase are proposed as the mechanisms underlying this protection. These results support the potential benefits of functional wine pomace seasonings in vascular complications associated with oxidative stress. |
| first_indexed | 2024-12-20T10:11:53Z |
| format | Article |
| id | doaj.art-1b823e639c03459bba891c62c22ebed3 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T10:11:53Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-1b823e639c03459bba891c62c22ebed32022-12-21T19:44:07ZengElsevierJournal of Functional Foods1756-46462016-04-0122431445Wine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cellsRaquel Del Pino-García0Gisela Gerardi1María D. Rivero-Pérez2María L. González-SanJosé3Javier García-Lomillo4Pilar Muñiz5Department of Food Biotechnology and Science, Faculty of Sciences, University of Burgos, Plaza Misael Bañuelos, 09001, Burgos, SpainDepartment of Food Biotechnology and Science, Faculty of Sciences, University of Burgos, Plaza Misael Bañuelos, 09001, Burgos, SpainDepartment of Food Biotechnology and Science, Faculty of Sciences, University of Burgos, Plaza Misael Bañuelos, 09001, Burgos, SpainDepartment of Food Biotechnology and Science, Faculty of Sciences, University of Burgos, Plaza Misael Bañuelos, 09001, Burgos, SpainDepartment of Food Biotechnology and Science, Faculty of Sciences, University of Burgos, Plaza Misael Bañuelos, 09001, Burgos, SpainCorresponding author. Facultad de Ciencias, Departamento de Biotecnología y Ciencia de los Alimentos, University of Burgos, Plaza Misael Bañuelos, 09001, Burgos, Spain. Tel.: +34 947258800 Ext. 8210; fax: +34 947258831.; Department of Food Biotechnology and Science, Faculty of Sciences, University of Burgos, Plaza Misael Bañuelos, 09001, Burgos, SpainDietary antioxidants such as phenolic phytochemicals may prevent/improve endothelial function impairment observed in cardiovascular diseases. This study investigates the specific protective effects of a vegetal seasoning obtained from seedless wine pomace against hyperglycaemia-induced oxidative damage and dysfunction in human umbilical vein endothelial cells EA.hy926. Non-cytotoxic doses of the bioactive compounds obtained following in vitro digestion of the seasoning were used as treatments. Digested compounds, especially colonic bacterial metabolites, restored a more balanced redox environment, prevented lipid peroxidation and cell membrane damage, ameliorated protein oxidation, and improved the balance between endothelial reactive oxygen species and nitric oxide production in hyperglycaemic cells. Reduction of angiotensin I-converting enzyme activity and gene modulation of superoxide dismutase, haem oxygenase-1, β-nicotinamide adenine dinucleotide phosphate oxidase-4, and endothelial nitric oxide synthase are proposed as the mechanisms underlying this protection. These results support the potential benefits of functional wine pomace seasonings in vascular complications associated with oxidative stress.http://www.sciencedirect.com/science/article/pii/S1756464616000554Colonic metabolitesDietary antioxidantsEndothelial functionHyperglycaemiaRedox signallingWine pomace |
| spellingShingle | Raquel Del Pino-García Gisela Gerardi María D. Rivero-Pérez María L. González-SanJosé Javier García-Lomillo Pilar Muñiz Wine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cells Journal of Functional Foods Colonic metabolites Dietary antioxidants Endothelial function Hyperglycaemia Redox signalling Wine pomace |
| title | Wine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cells |
| title_full | Wine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cells |
| title_fullStr | Wine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cells |
| title_full_unstemmed | Wine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cells |
| title_short | Wine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cells |
| title_sort | wine pomace seasoning attenuates hyperglycaemia induced endothelial dysfunction and oxidative damage in endothelial cells |
| topic | Colonic metabolites Dietary antioxidants Endothelial function Hyperglycaemia Redox signalling Wine pomace |
| url | http://www.sciencedirect.com/science/article/pii/S1756464616000554 |
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