Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes
Abstract Background Variation in host immune responses to SARS-CoV-2 is regulated by multiple genes involved in innate viral response and cytokine storm emergence like IL-10 and TNFa gene polymorphisms. We hypothesize that IL-10; -592 C > A and − 1082 A > G and TNFa-308 G > A are associated...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Medical Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12920-023-01793-4 |
| _version_ | 1827325801113059328 |
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| author | Raghda E. Eldesouki Rania M. Kishk Noha M. Abd El-Fadeal Rama I Mahran Noha Kamel Eman Riad Nader Nemr Safaa M. Kishk Eman Abdel-Moemen Mohammed |
| author_facet | Raghda E. Eldesouki Rania M. Kishk Noha M. Abd El-Fadeal Rama I Mahran Noha Kamel Eman Riad Nader Nemr Safaa M. Kishk Eman Abdel-Moemen Mohammed |
| author_sort | Raghda E. Eldesouki |
| collection | DOAJ |
| description | Abstract Background Variation in host immune responses to SARS-CoV-2 is regulated by multiple genes involved in innate viral response and cytokine storm emergence like IL-10 and TNFa gene polymorphisms. We hypothesize that IL-10; -592 C > A and − 1082 A > G and TNFa-308 G > A are associated with the risk of SARS-COV2 infections and clinical outcome. Methods Genotyping, laboratory and radiological investigations were done to 110 COVID-19 patients and 110 healthy subjects, in Ismailia, Egypt. Results A significant association between the − 592 A allele, A containing genotypes under all models (p < 0.0001), and TNFa A allele with risk to infection was observed but not with the G allele of the − 1082. The − 592 /-1082 CG and the − 592 /-1082/ -308 CGG haplotypes showed higher odds in COVID-19 patients. Severe lung affection was negatively associated with − 592, while positive association was observed with − 1082. Higher D-dimer levels were strongly associated with the − 1082 GG genotype. Survival outcomes were strongly associated with the GA genotype of TNFa. -308 as well as AGG and AAA haplotypes. Conclusion IL-10 and TNFa polymorphisms should be considered for clinical and epidemiological evaluation of COVID-19 patients. |
| first_indexed | 2024-03-07T14:35:35Z |
| format | Article |
| id | doaj.art-1b84110ef4794c8189da7cfffff85e6e |
| institution | Directory Open Access Journal |
| issn | 1755-8794 |
| language | English |
| last_indexed | 2024-03-07T14:35:35Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj.art-1b84110ef4794c8189da7cfffff85e6e2024-03-05T20:39:24ZengBMCBMC Medical Genomics1755-87942024-01-0117111110.1186/s12920-023-01793-4Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomesRaghda E. Eldesouki0Rania M. Kishk1Noha M. Abd El-Fadeal2Rama I Mahran3Noha Kamel4Eman Riad5Nader Nemr6Safaa M. Kishk7Eman Abdel-Moemen Mohammed8Genetics Unit, Histology Department, Faculty of Medicine, Suez Canal UniversityMicrobiology and immunology Department, Faculty of Medicine, Suez Canal UniversityMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal UniversityClinical Pharmacology Department, Faculty of Medicine, Suez Canal UniversityClinical Pathology Department, Faculty of Medicine, Suez Canal UniversityPulmonology Unit, Internal Medicine Department, Faculty of Medicine, Suez Canal UniversityEndemic and Infectious Diseases Department, Faculty of Medicine, Suez Canal UniversityPharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal UniversityGenetics Unit, Histology Department, Faculty of Medicine, Suez Canal UniversityAbstract Background Variation in host immune responses to SARS-CoV-2 is regulated by multiple genes involved in innate viral response and cytokine storm emergence like IL-10 and TNFa gene polymorphisms. We hypothesize that IL-10; -592 C > A and − 1082 A > G and TNFa-308 G > A are associated with the risk of SARS-COV2 infections and clinical outcome. Methods Genotyping, laboratory and radiological investigations were done to 110 COVID-19 patients and 110 healthy subjects, in Ismailia, Egypt. Results A significant association between the − 592 A allele, A containing genotypes under all models (p < 0.0001), and TNFa A allele with risk to infection was observed but not with the G allele of the − 1082. The − 592 /-1082 CG and the − 592 /-1082/ -308 CGG haplotypes showed higher odds in COVID-19 patients. Severe lung affection was negatively associated with − 592, while positive association was observed with − 1082. Higher D-dimer levels were strongly associated with the − 1082 GG genotype. Survival outcomes were strongly associated with the GA genotype of TNFa. -308 as well as AGG and AAA haplotypes. Conclusion IL-10 and TNFa polymorphisms should be considered for clinical and epidemiological evaluation of COVID-19 patients.https://doi.org/10.1186/s12920-023-01793-4SARS-CoV-2IL-10TNFars1800872 (− 592)rs1800896(− 1082)rs1800629(-308) |
| spellingShingle | Raghda E. Eldesouki Rania M. Kishk Noha M. Abd El-Fadeal Rama I Mahran Noha Kamel Eman Riad Nader Nemr Safaa M. Kishk Eman Abdel-Moemen Mohammed Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes BMC Medical Genomics SARS-CoV-2 IL-10 TNFa rs1800872 (− 592) rs1800896(− 1082) rs1800629(-308) |
| title | Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes |
| title_full | Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes |
| title_fullStr | Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes |
| title_full_unstemmed | Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes |
| title_short | Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes |
| title_sort | association of il 10 592 c a 1082 a g and the tnfα 308 g a with susceptibility to covid 19 and clinical outcomes |
| topic | SARS-CoV-2 IL-10 TNFa rs1800872 (− 592) rs1800896(− 1082) rs1800629(-308) |
| url | https://doi.org/10.1186/s12920-023-01793-4 |
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