The amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanisms
Emotionally arousing experiences are better remembered than neutral ones, highlighting that memory consolidation differentially promotes retention of experiences depending on their survival value. This paper reviews evidence indicating that the basolateral amygdala (BLA) mediates the facilitating in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-05-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289523000176 |
| _version_ | 1797812075025661952 |
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| author | Denis Paré Drew B. Headley |
| author_facet | Denis Paré Drew B. Headley |
| author_sort | Denis Paré |
| collection | DOAJ |
| description | Emotionally arousing experiences are better remembered than neutral ones, highlighting that memory consolidation differentially promotes retention of experiences depending on their survival value. This paper reviews evidence indicating that the basolateral amygdala (BLA) mediates the facilitating influence of emotions on memory through multiple mechanisms. Emotionally arousing events, in part by triggering the release of stress hormones, cause a long-lasting enhancement in the firing rate and synchrony of BLA neurons. BLA oscillations, particularly gamma, play an important role in synchronizing the activity of BLA neurons. In addition, BLA synapses are endowed with a unique property, an elevated post-synaptic expression of NMDA receptors. As a result, the synchronized gamma-related recruitment of BLA neurons facilitates synaptic plasticity at other inputs converging on the same target neurons. Given that emotional experiences are spontaneously remembered during wake and sleep, and that REM sleep is favorable to the consolidation of emotional memories, we propose a synthesis for the various lines of evidence mentioned above: gamma-related synchronized firing of BLA cells potentiates synapses between cortical neurons that were recruited during an emotional experience, either by tagging these cells for subsequent reactivation or by enhancing the effects of reactivation itself. |
| first_indexed | 2024-03-13T07:32:12Z |
| format | Article |
| id | doaj.art-1b857fc745304f23b883b8215064e6a9 |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-03-13T07:32:12Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-1b857fc745304f23b883b8215064e6a92023-06-04T04:24:01ZengElsevierNeurobiology of Stress2352-28952023-05-0124100529The amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanismsDenis Paré0Drew B. Headley1Corresponding author. Center for Molecular and Behavioral Neuroscience, Rutgers State University, 197 University Ave., Newark, NJ, 07102, USA.; Center for Molecular and Behavioral Neuroscience, Rutgers University - Newark, 197 University Avenue, Newark, NJ, 07102, USACenter for Molecular and Behavioral Neuroscience, Rutgers University - Newark, 197 University Avenue, Newark, NJ, 07102, USAEmotionally arousing experiences are better remembered than neutral ones, highlighting that memory consolidation differentially promotes retention of experiences depending on their survival value. This paper reviews evidence indicating that the basolateral amygdala (BLA) mediates the facilitating influence of emotions on memory through multiple mechanisms. Emotionally arousing events, in part by triggering the release of stress hormones, cause a long-lasting enhancement in the firing rate and synchrony of BLA neurons. BLA oscillations, particularly gamma, play an important role in synchronizing the activity of BLA neurons. In addition, BLA synapses are endowed with a unique property, an elevated post-synaptic expression of NMDA receptors. As a result, the synchronized gamma-related recruitment of BLA neurons facilitates synaptic plasticity at other inputs converging on the same target neurons. Given that emotional experiences are spontaneously remembered during wake and sleep, and that REM sleep is favorable to the consolidation of emotional memories, we propose a synthesis for the various lines of evidence mentioned above: gamma-related synchronized firing of BLA cells potentiates synapses between cortical neurons that were recruited during an emotional experience, either by tagging these cells for subsequent reactivation or by enhancing the effects of reactivation itself.http://www.sciencedirect.com/science/article/pii/S2352289523000176MemoryConsolidationAmygdalaReplayEmotionStress |
| spellingShingle | Denis Paré Drew B. Headley The amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanisms Neurobiology of Stress Memory Consolidation Amygdala Replay Emotion Stress |
| title | The amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanisms |
| title_full | The amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanisms |
| title_fullStr | The amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanisms |
| title_full_unstemmed | The amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanisms |
| title_short | The amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanisms |
| title_sort | amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanisms |
| topic | Memory Consolidation Amygdala Replay Emotion Stress |
| url | http://www.sciencedirect.com/science/article/pii/S2352289523000176 |
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