Total Matrix Ca2+ Modulates Ca2+ Efflux via the Ca2+/H+ Exchanger in Cardiac Mitochondria

Total Matrix Ca2+ Modulates Ca2+ Efflux via the Ca2+/H+ Exchanger in Cardiac Mitochondria

Mitochondrial Ca2+ handling is accomplished by balancing Ca2+ uptake, primarily via the Ru360-sensitive mitochondrial calcium uniporter (MCU), Ca2+ buffering in the matrix and Ca2+ efflux mainly via Ca2+ ion exchangers, such as the Na+/Ca2+ exchanger (NCLX) and the Ca2+/H+ exchanger (CHE). The mecha...

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Bibliographic Details
Main Authors: Gayathri K. Natarajan, Lyall Glait, Jyotsna Mishra, David F. Stowe, Amadou K. S. Camara, Wai-Meng Kwok
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Physiology
Subjects:
CHE
Ca2+/H+ exchanger
LETM1
calcium retention capacity
total matrix Ca2+
cardiac mitochondria
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.510600/full

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