The role of peptide and DNA vaccines in myeloid leukemia immunotherapy
<p>Abstract</p> <p>While chemotherapy and targeted therapy are successful in inducing the remission of myeloid leukemia as acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), the disease remains largely incurable. This observation is likely due to the drug resistance o...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2013-02-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | http://www.cancerci.com/content/13/1/13 |
| _version_ | 1828385214070521856 |
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| author | Lin Chen Li Yangqiu |
| author_facet | Lin Chen Li Yangqiu |
| author_sort | Lin Chen |
| collection | DOAJ |
| description | <p>Abstract</p> <p>While chemotherapy and targeted therapy are successful in inducing the remission of myeloid leukemia as acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), the disease remains largely incurable. This observation is likely due to the drug resistance of leukemic cells, which are responsible for disease relapse. Myeloid leukemia vaccines may most likely be beneficial for eradicating minimal residual disease after treatment with chemotherapy or targeted therapy. Several targeted immunotherapies using leukemia vaccines have been heavily investigated in clinical and preclinical trials. This review will focus on peptides and DNA vaccines in the context of myeloid leukemias, and optimal strategies for enhancing the efficacy of vaccines based on myeloid leukemia immunization are also summarized.</p> |
| first_indexed | 2024-12-10T05:16:42Z |
| format | Article |
| id | doaj.art-1b880ade3e6c4fd0855faf6fc0cab0c8 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-10T05:16:42Z |
| publishDate | 2013-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-1b880ade3e6c4fd0855faf6fc0cab0c82022-12-22T02:00:56ZengBMCCancer Cell International1475-28672013-02-011311310.1186/1475-2867-13-13The role of peptide and DNA vaccines in myeloid leukemia immunotherapyLin ChenLi Yangqiu<p>Abstract</p> <p>While chemotherapy and targeted therapy are successful in inducing the remission of myeloid leukemia as acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), the disease remains largely incurable. This observation is likely due to the drug resistance of leukemic cells, which are responsible for disease relapse. Myeloid leukemia vaccines may most likely be beneficial for eradicating minimal residual disease after treatment with chemotherapy or targeted therapy. Several targeted immunotherapies using leukemia vaccines have been heavily investigated in clinical and preclinical trials. This review will focus on peptides and DNA vaccines in the context of myeloid leukemias, and optimal strategies for enhancing the efficacy of vaccines based on myeloid leukemia immunization are also summarized.</p>http://www.cancerci.com/content/13/1/13DNA vaccinePeptide vaccineLeukemia-associated antigenMyeloid leukemiaImmunotherapy |
| spellingShingle | Lin Chen Li Yangqiu The role of peptide and DNA vaccines in myeloid leukemia immunotherapy Cancer Cell International DNA vaccine Peptide vaccine Leukemia-associated antigen Myeloid leukemia Immunotherapy |
| title | The role of peptide and DNA vaccines in myeloid leukemia immunotherapy |
| title_full | The role of peptide and DNA vaccines in myeloid leukemia immunotherapy |
| title_fullStr | The role of peptide and DNA vaccines in myeloid leukemia immunotherapy |
| title_full_unstemmed | The role of peptide and DNA vaccines in myeloid leukemia immunotherapy |
| title_short | The role of peptide and DNA vaccines in myeloid leukemia immunotherapy |
| title_sort | role of peptide and dna vaccines in myeloid leukemia immunotherapy |
| topic | DNA vaccine Peptide vaccine Leukemia-associated antigen Myeloid leukemia Immunotherapy |
| url | http://www.cancerci.com/content/13/1/13 |
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