Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body
The main microtubule organizing centre in the unicellular model organisms Saccharomyces cerevisiae and Schizosaccharomyces pompe is the spindle pole body (SPB). The SPB is a multilayer structure, which duplicates exactly once per cell cycle. Unlike higher eukaryotic cells, both yeast model organisms...
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MDPI AG
2018-05-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/7/5/42 |
| _version_ | 1797707639594942464 |
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| author | Diana Rüthnick Elmar Schiebel |
| author_facet | Diana Rüthnick Elmar Schiebel |
| author_sort | Diana Rüthnick |
| collection | DOAJ |
| description | The main microtubule organizing centre in the unicellular model organisms Saccharomyces cerevisiae and Schizosaccharomyces pompe is the spindle pole body (SPB). The SPB is a multilayer structure, which duplicates exactly once per cell cycle. Unlike higher eukaryotic cells, both yeast model organisms undergo mitosis without breakdown of the nuclear envelope (NE), a so-called closed mitosis. Therefore, in order to simultaneously nucleate nuclear and cytoplasmic MTs, it is vital to embed the SPB into the NE at least during mitosis, similarly to the nuclear pore complex (NPC). This review aims to embrace the current knowledge of the SPB duplication cycle with special emphasis on the critical step of the insertion of the new SPB into the NE. |
| first_indexed | 2024-03-12T06:10:21Z |
| format | Article |
| id | doaj.art-1b88bdd04cfe4843a293da50132478af |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:10:21Z |
| publishDate | 2018-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1b88bdd04cfe4843a293da50132478af2023-09-03T03:06:16ZengMDPI AGCells2073-44092018-05-01754210.3390/cells7050042cells7050042Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole BodyDiana Rüthnick0Elmar Schiebel1Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, 69120 Heidelberg, GermanyZentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, 69120 Heidelberg, GermanyThe main microtubule organizing centre in the unicellular model organisms Saccharomyces cerevisiae and Schizosaccharomyces pompe is the spindle pole body (SPB). The SPB is a multilayer structure, which duplicates exactly once per cell cycle. Unlike higher eukaryotic cells, both yeast model organisms undergo mitosis without breakdown of the nuclear envelope (NE), a so-called closed mitosis. Therefore, in order to simultaneously nucleate nuclear and cytoplasmic MTs, it is vital to embed the SPB into the NE at least during mitosis, similarly to the nuclear pore complex (NPC). This review aims to embrace the current knowledge of the SPB duplication cycle with special emphasis on the critical step of the insertion of the new SPB into the NE.http://www.mdpi.com/2073-4409/7/5/42spindle pole body (SPB)nuclear pore complex (NPC)nuclear envelope (NE) insertion |
| spellingShingle | Diana Rüthnick Elmar Schiebel Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body Cells spindle pole body (SPB) nuclear pore complex (NPC) nuclear envelope (NE) insertion |
| title | Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body |
| title_full | Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body |
| title_fullStr | Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body |
| title_full_unstemmed | Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body |
| title_short | Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body |
| title_sort | duplication and nuclear envelope insertion of the yeast microtubule organizing centre the spindle pole body |
| topic | spindle pole body (SPB) nuclear pore complex (NPC) nuclear envelope (NE) insertion |
| url | http://www.mdpi.com/2073-4409/7/5/42 |
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