Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease?
Abstract Introduction The retina is a potential source of noninvasive vascular biomarkers for Alzheimer's disease (AD). We assessed retinal microvasculature in well‐characterized AD cases, taking ophthalmological confounders into account. Methods We included 48 amyloid‐positive AD patients and...
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| Format: | Article |
| Language: | English |
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Wiley
2019-12-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2019.03.006 |
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| author | Jurre denHaan Jacoba A. van deKreeke Bart N. vanBerckel Frederik Barkhof Charlotte E. Teunissen Philip Scheltens Frank D. Verbraak Femke H. Bouwman |
| author_facet | Jurre denHaan Jacoba A. van deKreeke Bart N. vanBerckel Frederik Barkhof Charlotte E. Teunissen Philip Scheltens Frank D. Verbraak Femke H. Bouwman |
| author_sort | Jurre denHaan |
| collection | DOAJ |
| description | Abstract Introduction The retina is a potential source of noninvasive vascular biomarkers for Alzheimer's disease (AD). We assessed retinal microvasculature in well‐characterized AD cases, taking ophthalmological confounders into account. Methods We included 48 amyloid‐positive AD patients and 38 amyloid‐negative cognitively normal control subjects. All participants underwent ophthalmological screening to exclude interfering ocular disease. Using a multimodal approach, we measured retinal vascular parameters, choroidal thickness, macular vascular density, and foveal avascular zone size. Results We found no disease effects on retinal vascular measures (all β′s < |0.15|, all P > .2), adjusted for confounders. Venular tortuosity was inversely associated with Fazekas score in control subjects (β −0.56, P < .01), while vessel density in the outer ring of the macula was inversely associated with Fazekas score in AD cases (β −0.64, P < .01). Discussion In conclusion, retinal vasculature did not discriminate patients with AD from control subjects, despite evident changes on clinical, neuroimaging, and cerebrospinal fluid biomarkers, challenging the use of retinal vasculature measurements as AD biomarker. |
| first_indexed | 2024-12-12T14:28:50Z |
| format | Article |
| id | doaj.art-1b88e0d851074eaa98c6614cd69a1c4f |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-12-12T14:28:50Z |
| publishDate | 2019-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-1b88e0d851074eaa98c6614cd69a1c4f2022-12-22T00:21:36ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292019-12-0111138339110.1016/j.dadm.2019.03.006Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease?Jurre denHaan0Jacoba A. van deKreeke1Bart N. vanBerckel2Frederik Barkhof3Charlotte E. Teunissen4Philip Scheltens5Frank D. Verbraak6Femke H. Bouwman7Alzheimer Center AmsterdamDepartment of Neurology, Amsterdam NeuroscienceVrije Universiteit Amsterdam, Amsterdam UMCAmsterdamThe NetherlandsDepartment of OphthalmologyVrije Universiteit Amsterdam, Amsterdam UMCAmsterdamThe NetherlandsDepartment of Radiology and Nuclear Medicine, Amsterdam NeuroscienceVrije Universiteit Amsterdam, Amsterdam UMCAmsterdamThe NetherlandsDepartment of Radiology and Nuclear Medicine, Amsterdam NeuroscienceVrije Universiteit Amsterdam, Amsterdam UMCAmsterdamThe NetherlandsNeurochemistry Lab and BiobankDepartment of Clinical Chemistry, Amsterdam NeuroscienceVrije Universiteit Amsterdam, Amsterdam UMCAmsterdamThe NetherlandsAlzheimer Center AmsterdamDepartment of Neurology, Amsterdam NeuroscienceVrije Universiteit Amsterdam, Amsterdam UMCAmsterdamThe NetherlandsDepartment of OphthalmologyVrije Universiteit Amsterdam, Amsterdam UMCAmsterdamThe NetherlandsAlzheimer Center AmsterdamDepartment of Neurology, Amsterdam NeuroscienceVrije Universiteit Amsterdam, Amsterdam UMCAmsterdamThe NetherlandsAbstract Introduction The retina is a potential source of noninvasive vascular biomarkers for Alzheimer's disease (AD). We assessed retinal microvasculature in well‐characterized AD cases, taking ophthalmological confounders into account. Methods We included 48 amyloid‐positive AD patients and 38 amyloid‐negative cognitively normal control subjects. All participants underwent ophthalmological screening to exclude interfering ocular disease. Using a multimodal approach, we measured retinal vascular parameters, choroidal thickness, macular vascular density, and foveal avascular zone size. Results We found no disease effects on retinal vascular measures (all β′s < |0.15|, all P > .2), adjusted for confounders. Venular tortuosity was inversely associated with Fazekas score in control subjects (β −0.56, P < .01), while vessel density in the outer ring of the macula was inversely associated with Fazekas score in AD cases (β −0.64, P < .01). Discussion In conclusion, retinal vasculature did not discriminate patients with AD from control subjects, despite evident changes on clinical, neuroimaging, and cerebrospinal fluid biomarkers, challenging the use of retinal vasculature measurements as AD biomarker.https://doi.org/10.1016/j.dadm.2019.03.006Retinal vasculatureAlzheimer's diseaseBiomarkerChoroidal thicknessOCTAFundus photographs |
| spellingShingle | Jurre denHaan Jacoba A. van deKreeke Bart N. vanBerckel Frederik Barkhof Charlotte E. Teunissen Philip Scheltens Frank D. Verbraak Femke H. Bouwman Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease? Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Retinal vasculature Alzheimer's disease Biomarker Choroidal thickness OCTA Fundus photographs |
| title | Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease? |
| title_full | Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease? |
| title_fullStr | Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease? |
| title_full_unstemmed | Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease? |
| title_short | Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease? |
| title_sort | is retinal vasculature a biomarker in amyloid proven alzheimer s disease |
| topic | Retinal vasculature Alzheimer's disease Biomarker Choroidal thickness OCTA Fundus photographs |
| url | https://doi.org/10.1016/j.dadm.2019.03.006 |
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