Exploring the causal relationship between inflammatory cytokines and migraine: a bidirectional, two-sample Mendelian randomization study
Abstract To further evaluate the causal relationships between inflammatory cytokines and migraine, we conducted a bidirectional, two-sample Mendelian randomization (MR) analysis using genetic data from publicly available genome-wide association studies (GWAS). We used several MR methods, including r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-46797-3 |
| _version_ | 1797630215082475520 |
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| author | Chong Fu Yan Chen Wei Xu Yanping Zhang |
| author_facet | Chong Fu Yan Chen Wei Xu Yanping Zhang |
| author_sort | Chong Fu |
| collection | DOAJ |
| description | Abstract To further evaluate the causal relationships between inflammatory cytokines and migraine, we conducted a bidirectional, two-sample Mendelian randomization (MR) analysis using genetic data from publicly available genome-wide association studies (GWAS). We used several MR methods, including random-effect inverse-variance weighting (IVW), weighted median, MR-Egger, to test the causal relationships. Sensitivity analyses were also conducted to evaluate the robustness of the results. The results showed that hepatocyte growth factor (HGF) was positively associated with the risk of migraine (odds ratio [OR], 1.004; 95% confidence interval [CI], 1.001–1.008; P = 0.022). In addition, Interleukin-2 (IL-2) was considered a downstream consequence of migraine (OR, 0.012; 95% CI, 0.000–0.0929; P = 0.046). These findings suggest that HGF may be a factor associated with the etiology of migraine, while IL-2 is more likely to be involved in the downstream development of migraine. |
| first_indexed | 2024-03-11T11:05:03Z |
| format | Article |
| id | doaj.art-1b90f5db2de04a17b3e727edd8ad93d6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-11T11:05:03Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1b90f5db2de04a17b3e727edd8ad93d62023-11-12T12:15:34ZengNature PortfolioScientific Reports2045-23222023-11-011311910.1038/s41598-023-46797-3Exploring the causal relationship between inflammatory cytokines and migraine: a bidirectional, two-sample Mendelian randomization studyChong Fu0Yan Chen1Wei Xu2Yanping Zhang3Department of Gastroenterology, Anqing Municipal HospitalDepartment of Gastroenterology, Anqing Municipal HospitalDepartment of Gastroenterology, Anqing Municipal HospitalDepartment of Gastroenterology, Anqing Municipal HospitalAbstract To further evaluate the causal relationships between inflammatory cytokines and migraine, we conducted a bidirectional, two-sample Mendelian randomization (MR) analysis using genetic data from publicly available genome-wide association studies (GWAS). We used several MR methods, including random-effect inverse-variance weighting (IVW), weighted median, MR-Egger, to test the causal relationships. Sensitivity analyses were also conducted to evaluate the robustness of the results. The results showed that hepatocyte growth factor (HGF) was positively associated with the risk of migraine (odds ratio [OR], 1.004; 95% confidence interval [CI], 1.001–1.008; P = 0.022). In addition, Interleukin-2 (IL-2) was considered a downstream consequence of migraine (OR, 0.012; 95% CI, 0.000–0.0929; P = 0.046). These findings suggest that HGF may be a factor associated with the etiology of migraine, while IL-2 is more likely to be involved in the downstream development of migraine.https://doi.org/10.1038/s41598-023-46797-3 |
| spellingShingle | Chong Fu Yan Chen Wei Xu Yanping Zhang Exploring the causal relationship between inflammatory cytokines and migraine: a bidirectional, two-sample Mendelian randomization study Scientific Reports |
| title | Exploring the causal relationship between inflammatory cytokines and migraine: a bidirectional, two-sample Mendelian randomization study |
| title_full | Exploring the causal relationship between inflammatory cytokines and migraine: a bidirectional, two-sample Mendelian randomization study |
| title_fullStr | Exploring the causal relationship between inflammatory cytokines and migraine: a bidirectional, two-sample Mendelian randomization study |
| title_full_unstemmed | Exploring the causal relationship between inflammatory cytokines and migraine: a bidirectional, two-sample Mendelian randomization study |
| title_short | Exploring the causal relationship between inflammatory cytokines and migraine: a bidirectional, two-sample Mendelian randomization study |
| title_sort | exploring the causal relationship between inflammatory cytokines and migraine a bidirectional two sample mendelian randomization study |
| url | https://doi.org/10.1038/s41598-023-46797-3 |
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