In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing
Rapid wound dressings provide an excellent solution strategy for the treatment of wounds in emergency situations. In this study, aqueous solvent-based PVA/SF/SA/GelMA nanofiber dressings fabricated by a handheld electrospinning device could deposit quickly and directly on the wound, perfectly fittin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/21/4/241 |
| _version_ | 1797604581696339968 |
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| author | Shanfei Liu Guilin Wu Wen Wang Heng Wang Yingjun Gao Xuhong Yang |
| author_facet | Shanfei Liu Guilin Wu Wen Wang Heng Wang Yingjun Gao Xuhong Yang |
| author_sort | Shanfei Liu |
| collection | DOAJ |
| description | Rapid wound dressings provide an excellent solution strategy for the treatment of wounds in emergency situations. In this study, aqueous solvent-based PVA/SF/SA/GelMA nanofiber dressings fabricated by a handheld electrospinning device could deposit quickly and directly on the wound, perfectly fitting wounds with various sizes. Using an aqueous solvent overcame the disadvantage of using the current organic solvents as the medium for rapid wound dressings. The porous dressings had excellent air permeability to ensure smooth gas exchange at the wound site. The distribution range of the tensile strength of the dressings was 9–12 Kpa, and the tensile strain was between 60–80%, providing sufficient mechanical support during wound healing. The dressings could absorb 4–8 times their own weight in solution and could rapidly absorb wound exudates from wet wounds. The nanofibers formed ionic crosslinked hydrogel after absorbing exudates, maintaining the moist condition. It formed a hydrogel–nanofiber composite structure with un-gelled nanofibers and combined the photocrosslinking network to maintain a stable structure at the wound location. The in vitro cell culture assay indicated that the dressings had excellent cell cytocompatibility, and the addition of SF contributed to cell proliferation and wound healing. The in situ deposited nanofiber dressings had excellent potential in the urgent treatment of emergency wounds. |
| first_indexed | 2024-03-11T04:48:18Z |
| format | Article |
| id | doaj.art-1b91c8c28aaa4d5dbddd119370727b2a |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-11T04:48:18Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-1b91c8c28aaa4d5dbddd119370727b2a2023-11-17T20:10:28ZengMDPI AGMarine Drugs1660-33972023-04-0121424110.3390/md21040241In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound HealingShanfei Liu0Guilin Wu1Wen Wang2Heng Wang3Yingjun Gao4Xuhong Yang5National Engineering Laboratory for Modern Silk, Key Laboratory of Flame Retardancy Finishing of Textile Materials (CNTAC), College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, Key Laboratory of Flame Retardancy Finishing of Textile Materials (CNTAC), College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, Key Laboratory of Flame Retardancy Finishing of Textile Materials (CNTAC), College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, Key Laboratory of Flame Retardancy Finishing of Textile Materials (CNTAC), College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, Key Laboratory of Flame Retardancy Finishing of Textile Materials (CNTAC), College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, Key Laboratory of Flame Retardancy Finishing of Textile Materials (CNTAC), College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaRapid wound dressings provide an excellent solution strategy for the treatment of wounds in emergency situations. In this study, aqueous solvent-based PVA/SF/SA/GelMA nanofiber dressings fabricated by a handheld electrospinning device could deposit quickly and directly on the wound, perfectly fitting wounds with various sizes. Using an aqueous solvent overcame the disadvantage of using the current organic solvents as the medium for rapid wound dressings. The porous dressings had excellent air permeability to ensure smooth gas exchange at the wound site. The distribution range of the tensile strength of the dressings was 9–12 Kpa, and the tensile strain was between 60–80%, providing sufficient mechanical support during wound healing. The dressings could absorb 4–8 times their own weight in solution and could rapidly absorb wound exudates from wet wounds. The nanofibers formed ionic crosslinked hydrogel after absorbing exudates, maintaining the moist condition. It formed a hydrogel–nanofiber composite structure with un-gelled nanofibers and combined the photocrosslinking network to maintain a stable structure at the wound location. The in vitro cell culture assay indicated that the dressings had excellent cell cytocompatibility, and the addition of SF contributed to cell proliferation and wound healing. The in situ deposited nanofiber dressings had excellent potential in the urgent treatment of emergency wounds.https://www.mdpi.com/1660-3397/21/4/241in situ depositionhandheld electrospinningnanofiber dressings“dry-wet” conversionwound healing |
| spellingShingle | Shanfei Liu Guilin Wu Wen Wang Heng Wang Yingjun Gao Xuhong Yang In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing Marine Drugs in situ deposition handheld electrospinning nanofiber dressings “dry-wet” conversion wound healing |
| title | In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing |
| title_full | In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing |
| title_fullStr | In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing |
| title_full_unstemmed | In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing |
| title_short | In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing |
| title_sort | in situ electrospinning of dry wet conversion nanofiber dressings for wound healing |
| topic | in situ deposition handheld electrospinning nanofiber dressings “dry-wet” conversion wound healing |
| url | https://www.mdpi.com/1660-3397/21/4/241 |
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