The non-attached biofilm aggregate
Abstract Biofilms have conventionally been perceived as dense bacterial masses on surfaces, following the five-step model of development. Initial biofilm research focused on surface-attached formations, but detached aggregates have received increasing attention in the past decade due to their pivota...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05281-4 |
| _version_ | 1797557125401018368 |
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| author | Kasper N. Kragh Tim Tolker-Nielsen Mads Lichtenberg |
| author_facet | Kasper N. Kragh Tim Tolker-Nielsen Mads Lichtenberg |
| author_sort | Kasper N. Kragh |
| collection | DOAJ |
| description | Abstract Biofilms have conventionally been perceived as dense bacterial masses on surfaces, following the five-step model of development. Initial biofilm research focused on surface-attached formations, but detached aggregates have received increasing attention in the past decade due to their pivotal role in chronic infections. Understanding their nature sparked fervent discussions in biofilm conferences and scientific literature. This review consolidates current insights on non-attached aggregates, offering examples of their occurrence in nature and diseases. We discuss their formation and dispersion mechanisms, resilience to antibiotics and immune-responses, drawing parallels to surface-attached biofilms. Moreover, we outline available in vitro models for studying non-attached aggregates. |
| first_indexed | 2024-03-10T17:12:50Z |
| format | Article |
| id | doaj.art-1b93135efd7349a2b7e7ed1e917d7b8f |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-10T17:12:50Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-1b93135efd7349a2b7e7ed1e917d7b8f2023-11-20T10:35:00ZengNature PortfolioCommunications Biology2399-36422023-09-016111310.1038/s42003-023-05281-4The non-attached biofilm aggregateKasper N. Kragh0Tim Tolker-Nielsen1Mads Lichtenberg2Costerton Biofilm Center, Department of Immunology and Microbiology, University of CopenhagenCosterton Biofilm Center, Department of Immunology and Microbiology, University of CopenhagenCosterton Biofilm Center, Department of Immunology and Microbiology, University of CopenhagenAbstract Biofilms have conventionally been perceived as dense bacterial masses on surfaces, following the five-step model of development. Initial biofilm research focused on surface-attached formations, but detached aggregates have received increasing attention in the past decade due to their pivotal role in chronic infections. Understanding their nature sparked fervent discussions in biofilm conferences and scientific literature. This review consolidates current insights on non-attached aggregates, offering examples of their occurrence in nature and diseases. We discuss their formation and dispersion mechanisms, resilience to antibiotics and immune-responses, drawing parallels to surface-attached biofilms. Moreover, we outline available in vitro models for studying non-attached aggregates.https://doi.org/10.1038/s42003-023-05281-4 |
| spellingShingle | Kasper N. Kragh Tim Tolker-Nielsen Mads Lichtenberg The non-attached biofilm aggregate Communications Biology |
| title | The non-attached biofilm aggregate |
| title_full | The non-attached biofilm aggregate |
| title_fullStr | The non-attached biofilm aggregate |
| title_full_unstemmed | The non-attached biofilm aggregate |
| title_short | The non-attached biofilm aggregate |
| title_sort | non attached biofilm aggregate |
| url | https://doi.org/10.1038/s42003-023-05281-4 |
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