Prognostic Value of Malondialdehyde (MDA) in the Temporal Progression of Chronic Spinal Cord Injury
Background: Oxidative stress is a major signature of spinal cord injury (SCI). The altered levels of various oxidative stress markers have been demonstrated in acute and chronic SCI. However, the variation of these markers in patients with chronic SCI depending on the time since the initial injury h...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/4/626 |
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| author | Sergio Haro Girón Jorge Monserrat Sanz Miguel A. Ortega Cielo Garcia-Montero Oscar Fraile-Martínez Ana M. Gómez-Lahoz Diego Liviu Boaru Diego de Leon-Oliva Luis G. Guijarro Mar Atienza-Perez David Diaz Elisa Lopez-Dolado Melchor Álvarez-Mon |
| author_facet | Sergio Haro Girón Jorge Monserrat Sanz Miguel A. Ortega Cielo Garcia-Montero Oscar Fraile-Martínez Ana M. Gómez-Lahoz Diego Liviu Boaru Diego de Leon-Oliva Luis G. Guijarro Mar Atienza-Perez David Diaz Elisa Lopez-Dolado Melchor Álvarez-Mon |
| author_sort | Sergio Haro Girón |
| collection | DOAJ |
| description | Background: Oxidative stress is a major signature of spinal cord injury (SCI). The altered levels of various oxidative stress markers have been demonstrated in acute and chronic SCI. However, the variation of these markers in patients with chronic SCI depending on the time since the initial injury has not been explored yet. Objective: Our aim was to measure plasma levels of malondialdehyde (MDA), a marker of lipid peroxidation in patients with SCI stratified in different periods of suffering the injury (0–5 years, 5–10 years, and more than 10 years). Patients and methods: This cross-sectional study enrolled patients with SCI (N = 105) from different periods of the lesion and healthy control (HC) subjects (N = 38): short period (SCI SP, N = 31, time of evolution less than 5 years); early chronic (SCI ECP, N = 32, time of evolution 5–15 years); and late chronic (SCI LCP, N = 42, time of evolution more than 15 years). The plasma levels of MDA were measured using a commercially available colorimetric assay. Results: Patients with SCI had significantly higher plasma levels of MDA than HC subjects. Receiver operating characteristic (ROC) curve analysis for plasma MDA levels in patients with SCI demonstrated areas under the curve (AUC) of 1 (HC vs. SCI-SP); 0.998 (HC vs. SCI-ECP); and 0.964 (HC vs. SCI-LCP). Additionally, three ROC curves were used to compare the different concentrations of MDA between the subgroups of patients with SCI, and the resulting AUCs were: 0.896 (SCI-SP vs. SCI-ECP); 0.840 (SCI-ECP vs. SCI-LCP); and 0.979 (SCI-SP vs. SCI-LCP). Conclusion: Plasma concentration of MDA can be considered as an oxidative stress biomarker to assess the prognosis of SCI in chronic stages. |
| first_indexed | 2024-03-11T04:50:43Z |
| format | Article |
| id | doaj.art-1b968d76a30f46a384f68fac866133c2 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T04:50:43Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-1b968d76a30f46a384f68fac866133c22023-11-17T19:59:49ZengMDPI AGJournal of Personalized Medicine2075-44262023-04-0113462610.3390/jpm13040626Prognostic Value of Malondialdehyde (MDA) in the Temporal Progression of Chronic Spinal Cord InjurySergio Haro Girón0Jorge Monserrat Sanz1Miguel A. Ortega2Cielo Garcia-Montero3Oscar Fraile-Martínez4Ana M. Gómez-Lahoz5Diego Liviu Boaru6Diego de Leon-Oliva7Luis G. Guijarro8Mar Atienza-Perez9David Diaz10Elisa Lopez-Dolado11Melchor Álvarez-Mon12Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, SpainService of Rehabilitation, National Hospital for Paraplegic Patients, Carr. de la Peraleda, S/N, 45004 Toledo, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainBackground: Oxidative stress is a major signature of spinal cord injury (SCI). The altered levels of various oxidative stress markers have been demonstrated in acute and chronic SCI. However, the variation of these markers in patients with chronic SCI depending on the time since the initial injury has not been explored yet. Objective: Our aim was to measure plasma levels of malondialdehyde (MDA), a marker of lipid peroxidation in patients with SCI stratified in different periods of suffering the injury (0–5 years, 5–10 years, and more than 10 years). Patients and methods: This cross-sectional study enrolled patients with SCI (N = 105) from different periods of the lesion and healthy control (HC) subjects (N = 38): short period (SCI SP, N = 31, time of evolution less than 5 years); early chronic (SCI ECP, N = 32, time of evolution 5–15 years); and late chronic (SCI LCP, N = 42, time of evolution more than 15 years). The plasma levels of MDA were measured using a commercially available colorimetric assay. Results: Patients with SCI had significantly higher plasma levels of MDA than HC subjects. Receiver operating characteristic (ROC) curve analysis for plasma MDA levels in patients with SCI demonstrated areas under the curve (AUC) of 1 (HC vs. SCI-SP); 0.998 (HC vs. SCI-ECP); and 0.964 (HC vs. SCI-LCP). Additionally, three ROC curves were used to compare the different concentrations of MDA between the subgroups of patients with SCI, and the resulting AUCs were: 0.896 (SCI-SP vs. SCI-ECP); 0.840 (SCI-ECP vs. SCI-LCP); and 0.979 (SCI-SP vs. SCI-LCP). Conclusion: Plasma concentration of MDA can be considered as an oxidative stress biomarker to assess the prognosis of SCI in chronic stages.https://www.mdpi.com/2075-4426/13/4/626malondialdehyde (MDA)spinal cord injury (SCI)plasma biomarkeroxidative stresslipid peroxidationprognosis |
| spellingShingle | Sergio Haro Girón Jorge Monserrat Sanz Miguel A. Ortega Cielo Garcia-Montero Oscar Fraile-Martínez Ana M. Gómez-Lahoz Diego Liviu Boaru Diego de Leon-Oliva Luis G. Guijarro Mar Atienza-Perez David Diaz Elisa Lopez-Dolado Melchor Álvarez-Mon Prognostic Value of Malondialdehyde (MDA) in the Temporal Progression of Chronic Spinal Cord Injury Journal of Personalized Medicine malondialdehyde (MDA) spinal cord injury (SCI) plasma biomarker oxidative stress lipid peroxidation prognosis |
| title | Prognostic Value of Malondialdehyde (MDA) in the Temporal Progression of Chronic Spinal Cord Injury |
| title_full | Prognostic Value of Malondialdehyde (MDA) in the Temporal Progression of Chronic Spinal Cord Injury |
| title_fullStr | Prognostic Value of Malondialdehyde (MDA) in the Temporal Progression of Chronic Spinal Cord Injury |
| title_full_unstemmed | Prognostic Value of Malondialdehyde (MDA) in the Temporal Progression of Chronic Spinal Cord Injury |
| title_short | Prognostic Value of Malondialdehyde (MDA) in the Temporal Progression of Chronic Spinal Cord Injury |
| title_sort | prognostic value of malondialdehyde mda in the temporal progression of chronic spinal cord injury |
| topic | malondialdehyde (MDA) spinal cord injury (SCI) plasma biomarker oxidative stress lipid peroxidation prognosis |
| url | https://www.mdpi.com/2075-4426/13/4/626 |
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