Safety of Combination of a Tetravalent Meningococcal Conjugate Vaccine Against Serogroups A, C, Y, W-135 With Other Vaccine Preparations: a Prospective Study of a Series of Cases Among Healthy Children and Children With Various Health Abnormalities
Meningococcal infection is an acute disease caused by Neisseria meningitidis, which proceeds with a diverse clinical aspect from nasopharyngitis to meningococcal meningitis and meningococcemia. Since 2014, a tetravalent meningococcal conjugate vaccine has been registered in Russia. This vaccine crea...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2017-06-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/1747 |
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| author | Leyla S. Namazova-Baranova Daria A. Novikova Marina V. Fedoseenko Anna G. Gaivoronskaya Natalia E. Tkachenko Tatiana A. Kaljuzhnaya Firuza Ch. Shakhtakhtinskaya Marika I. Broeva |
| author_facet | Leyla S. Namazova-Baranova Daria A. Novikova Marina V. Fedoseenko Anna G. Gaivoronskaya Natalia E. Tkachenko Tatiana A. Kaljuzhnaya Firuza Ch. Shakhtakhtinskaya Marika I. Broeva |
| author_sort | Leyla S. Namazova-Baranova |
| collection | DOAJ |
| description | Meningococcal infection is an acute disease caused by Neisseria meningitidis, which proceeds with a diverse clinical aspect from nasopharyngitis to meningococcal meningitis and meningococcemia. Since 2014, a tetravalent meningococcal conjugate vaccine has been registered in Russia. This vaccine creates protection against serogroups A, C, W-135, Y and can be used from the age of nine months to 55 years. The actual issue is a vaccine tolerability, including when combined with other vaccine preparations.Objective: Our aim was to evaluate the safety of a tetravalent meningococcal conjugate vaccine against serogroups A, C, Y and W-135 when it is combined with other vaccine preparations.Methods. A prospective full-design study assessed the tolerability of immunization with a meningococcal conjugate vaccine, both in case of monovaccination and in combination with a pneumococcal 13-valent conjugate vaccine, measles-mumps-rubella, viral hepatitis A, influenza, and chicken pox vaccines.Results. 97 children aged from 9 months to 18 years were vaccinated, 20 of them were healthy and 77 had medical issues (with allergic pathology, ENT diseases, cardiovascular and nervous system diseases, lung diseases as well as orphan diseases). Among vaccinated children, general reactions were observed in 3/97 (3.1%) children, local reactions — in 5 (5.2%). The post-vaccination period passed asymptomatically and uneventfully in the prevailing majority of children vaccinated with a tetravalent meningococcal conjugate vaccine (in 91, 93.8%).Conclusion. The immunization with a tetravalent meningococcal conjugate vaccine against serogroups A, C, Y, W-135 is well tolerated, both in case of monovaccination and in combination with other vaccine preparations, in healthy children of different age groups and in patients with different health status. |
| first_indexed | 2024-03-12T03:44:16Z |
| format | Article |
| id | doaj.art-1b96d15d7bb74235aa569554746487e3 |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2024-03-12T03:44:16Z |
| publishDate | 2017-06-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-1b96d15d7bb74235aa569554746487e32023-09-03T12:58:12Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352017-06-0116215616210.15690/vsp.v16i2.17171675Safety of Combination of a Tetravalent Meningococcal Conjugate Vaccine Against Serogroups A, C, Y, W-135 With Other Vaccine Preparations: a Prospective Study of a Series of Cases Among Healthy Children and Children With Various Health AbnormalitiesLeyla S. Namazova-Baranova0Daria A. Novikova1Marina V. Fedoseenko2Anna G. Gaivoronskaya3Natalia E. Tkachenko4Tatiana A. Kaljuzhnaya5Firuza Ch. Shakhtakhtinskaya6Marika I. Broeva7Национальный научно-практический центр здоровья детей; Российский национальный исследовательский медицинский университет им. Н.И. ПироговаНациональный научно-практический центр здоровья детейНациональный научно-практический центр здоровья детейНациональный научно-практический центр здоровья детейНациональный научно-практический центр здоровья детейНациональный научно-практический центр здоровья детейНациональный научно-практический центр здоровья детейНациональный научно-практический центр здоровья детейMeningococcal infection is an acute disease caused by Neisseria meningitidis, which proceeds with a diverse clinical aspect from nasopharyngitis to meningococcal meningitis and meningococcemia. Since 2014, a tetravalent meningococcal conjugate vaccine has been registered in Russia. This vaccine creates protection against serogroups A, C, W-135, Y and can be used from the age of nine months to 55 years. The actual issue is a vaccine tolerability, including when combined with other vaccine preparations.Objective: Our aim was to evaluate the safety of a tetravalent meningococcal conjugate vaccine against serogroups A, C, Y and W-135 when it is combined with other vaccine preparations.Methods. A prospective full-design study assessed the tolerability of immunization with a meningococcal conjugate vaccine, both in case of monovaccination and in combination with a pneumococcal 13-valent conjugate vaccine, measles-mumps-rubella, viral hepatitis A, influenza, and chicken pox vaccines.Results. 97 children aged from 9 months to 18 years were vaccinated, 20 of them were healthy and 77 had medical issues (with allergic pathology, ENT diseases, cardiovascular and nervous system diseases, lung diseases as well as orphan diseases). Among vaccinated children, general reactions were observed in 3/97 (3.1%) children, local reactions — in 5 (5.2%). The post-vaccination period passed asymptomatically and uneventfully in the prevailing majority of children vaccinated with a tetravalent meningococcal conjugate vaccine (in 91, 93.8%).Conclusion. The immunization with a tetravalent meningococcal conjugate vaccine against serogroups A, C, Y, W-135 is well tolerated, both in case of monovaccination and in combination with other vaccine preparations, in healthy children of different age groups and in patients with different health status.https://vsp.spr-journal.ru/jour/article/view/1747детименингококковая инфекциявакцинациячетырехвалентная конъюгированная менингококковая вакцинапереносимость вакцинации |
| spellingShingle | Leyla S. Namazova-Baranova Daria A. Novikova Marina V. Fedoseenko Anna G. Gaivoronskaya Natalia E. Tkachenko Tatiana A. Kaljuzhnaya Firuza Ch. Shakhtakhtinskaya Marika I. Broeva Safety of Combination of a Tetravalent Meningococcal Conjugate Vaccine Against Serogroups A, C, Y, W-135 With Other Vaccine Preparations: a Prospective Study of a Series of Cases Among Healthy Children and Children With Various Health Abnormalities Вопросы современной педиатрии дети менингококковая инфекция вакцинация четырехвалентная конъюгированная менингококковая вакцина переносимость вакцинации |
| title | Safety of Combination of a Tetravalent Meningococcal Conjugate Vaccine Against Serogroups A, C, Y, W-135 With Other Vaccine Preparations: a Prospective Study of a Series of Cases Among Healthy Children and Children With Various Health Abnormalities |
| title_full | Safety of Combination of a Tetravalent Meningococcal Conjugate Vaccine Against Serogroups A, C, Y, W-135 With Other Vaccine Preparations: a Prospective Study of a Series of Cases Among Healthy Children and Children With Various Health Abnormalities |
| title_fullStr | Safety of Combination of a Tetravalent Meningococcal Conjugate Vaccine Against Serogroups A, C, Y, W-135 With Other Vaccine Preparations: a Prospective Study of a Series of Cases Among Healthy Children and Children With Various Health Abnormalities |
| title_full_unstemmed | Safety of Combination of a Tetravalent Meningococcal Conjugate Vaccine Against Serogroups A, C, Y, W-135 With Other Vaccine Preparations: a Prospective Study of a Series of Cases Among Healthy Children and Children With Various Health Abnormalities |
| title_short | Safety of Combination of a Tetravalent Meningococcal Conjugate Vaccine Against Serogroups A, C, Y, W-135 With Other Vaccine Preparations: a Prospective Study of a Series of Cases Among Healthy Children and Children With Various Health Abnormalities |
| title_sort | safety of combination of a tetravalent meningococcal conjugate vaccine against serogroups a c y w 135 with other vaccine preparations a prospective study of a series of cases among healthy children and children with various health abnormalities |
| topic | дети менингококковая инфекция вакцинация четырехвалентная конъюгированная менингококковая вакцина переносимость вакцинации |
| url | https://vsp.spr-journal.ru/jour/article/view/1747 |
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