Effects of Codonopsis pilosula crude polysaccharides by hypoglycemic and modulating gut microbiome in a high-fat diet and streptozotocin-induced mouse model of T2DM
The study explored the nature and structure of ultrasonically extracted Codonopsis pilosulae crude polysaccharides (CPCPs) and the effects of CPCPs on hypoglycemic effects and gut flora in a high glucose and high-fat feeding and STZ-induced T2DM mice model. The results showed that the CPCPs consiste...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623004930 |
| _version_ | 1797435788512722944 |
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| author | Mingjun Yang Jinhui Lv Jumei Yang Shuhong Yang Fang Wang Yonggang Wang Chun Zhang |
| author_facet | Mingjun Yang Jinhui Lv Jumei Yang Shuhong Yang Fang Wang Yonggang Wang Chun Zhang |
| author_sort | Mingjun Yang |
| collection | DOAJ |
| description | The study explored the nature and structure of ultrasonically extracted Codonopsis pilosulae crude polysaccharides (CPCPs) and the effects of CPCPs on hypoglycemic effects and gut flora in a high glucose and high-fat feeding and STZ-induced T2DM mice model. The results showed that the CPCPs consisted mainly of polysaccharides, uronic acids, proteins and SO42−. CPCPs consisted of β-type pyranose and exhibited porous, irregular fibrillation and aggregation, and inhibited the activity of α-amylase and α-glucosidase. 1 g/kg CPCPs reduced diabetic symptoms, including modulation of body weight and blood biochemistry levels, reduced blood sugar and lipids, liver, kidney, pancreas indices, oxidative damage and inflammatory factor levels in T2DM mice. For diabetic mice gut microbes, 1 g/kg CPCPs reduced the ratio of Firmicutes and Bacteroidetes; at the genus level and reduced Enterobacter abundance and increased Bacteroides abundance. These results suggested that CPCPs may be effective supplements for preventing or treating of T2DM. |
| first_indexed | 2024-03-09T10:53:05Z |
| format | Article |
| id | doaj.art-1b98d15d5b9546c8be76e14afcefc54e |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-09T10:53:05Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-1b98d15d5b9546c8be76e14afcefc54e2023-12-01T05:01:12ZengElsevierJournal of Functional Foods1756-46462023-12-01111105893Effects of Codonopsis pilosula crude polysaccharides by hypoglycemic and modulating gut microbiome in a high-fat diet and streptozotocin-induced mouse model of T2DMMingjun Yang0Jinhui Lv1Jumei Yang2Shuhong Yang3Fang Wang4Yonggang Wang5Chun Zhang6School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaCuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou 730030, ChinaSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China; Corresponding author at: School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China.Hospital of Lanzhou University of Technology, Lanzhou 730050, ChinaThe study explored the nature and structure of ultrasonically extracted Codonopsis pilosulae crude polysaccharides (CPCPs) and the effects of CPCPs on hypoglycemic effects and gut flora in a high glucose and high-fat feeding and STZ-induced T2DM mice model. The results showed that the CPCPs consisted mainly of polysaccharides, uronic acids, proteins and SO42−. CPCPs consisted of β-type pyranose and exhibited porous, irregular fibrillation and aggregation, and inhibited the activity of α-amylase and α-glucosidase. 1 g/kg CPCPs reduced diabetic symptoms, including modulation of body weight and blood biochemistry levels, reduced blood sugar and lipids, liver, kidney, pancreas indices, oxidative damage and inflammatory factor levels in T2DM mice. For diabetic mice gut microbes, 1 g/kg CPCPs reduced the ratio of Firmicutes and Bacteroidetes; at the genus level and reduced Enterobacter abundance and increased Bacteroides abundance. These results suggested that CPCPs may be effective supplements for preventing or treating of T2DM.http://www.sciencedirect.com/science/article/pii/S1756464623004930Codonopsis pilosulaePolysaccharideT2DMGut microbesOxidative stressBlood sugar |
| spellingShingle | Mingjun Yang Jinhui Lv Jumei Yang Shuhong Yang Fang Wang Yonggang Wang Chun Zhang Effects of Codonopsis pilosula crude polysaccharides by hypoglycemic and modulating gut microbiome in a high-fat diet and streptozotocin-induced mouse model of T2DM Journal of Functional Foods Codonopsis pilosulae Polysaccharide T2DM Gut microbes Oxidative stress Blood sugar |
| title | Effects of Codonopsis pilosula crude polysaccharides by hypoglycemic and modulating gut microbiome in a high-fat diet and streptozotocin-induced mouse model of T2DM |
| title_full | Effects of Codonopsis pilosula crude polysaccharides by hypoglycemic and modulating gut microbiome in a high-fat diet and streptozotocin-induced mouse model of T2DM |
| title_fullStr | Effects of Codonopsis pilosula crude polysaccharides by hypoglycemic and modulating gut microbiome in a high-fat diet and streptozotocin-induced mouse model of T2DM |
| title_full_unstemmed | Effects of Codonopsis pilosula crude polysaccharides by hypoglycemic and modulating gut microbiome in a high-fat diet and streptozotocin-induced mouse model of T2DM |
| title_short | Effects of Codonopsis pilosula crude polysaccharides by hypoglycemic and modulating gut microbiome in a high-fat diet and streptozotocin-induced mouse model of T2DM |
| title_sort | effects of codonopsis pilosula crude polysaccharides by hypoglycemic and modulating gut microbiome in a high fat diet and streptozotocin induced mouse model of t2dm |
| topic | Codonopsis pilosulae Polysaccharide T2DM Gut microbes Oxidative stress Blood sugar |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623004930 |
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