Targeting metabolism of breast cancer and its implications in T cell immunotherapy
Breast cancer is a prominent health issue amongst women around the world. Immunotherapies including tumor targeted antibodies, adoptive T cell therapy, vaccines, and immune checkpoint blockers have rejuvenated the clinical management of breast cancer, but the prognosis of patients remains dismal. Me...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1381970/full |
| _version_ | 1797213506490073088 |
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| author | Jialuo Zou Cunjun Mai Zhiqin Lin Jian Zhou Guie Lai |
| author_facet | Jialuo Zou Cunjun Mai Zhiqin Lin Jian Zhou Guie Lai |
| author_sort | Jialuo Zou |
| collection | DOAJ |
| description | Breast cancer is a prominent health issue amongst women around the world. Immunotherapies including tumor targeted antibodies, adoptive T cell therapy, vaccines, and immune checkpoint blockers have rejuvenated the clinical management of breast cancer, but the prognosis of patients remains dismal. Metabolic reprogramming and immune escape are two important mechanisms supporting the progression of breast cancer. The deprivation uptake of nutrients (such as glucose, amino acid, and lipid) by breast cancer cells has a significant impact on tumor growth and microenvironment remodeling. In recent years, in-depth researches on the mechanism of metabolic reprogramming and immune escape have been extensively conducted, and targeting metabolic reprogramming has been proposed as a new therapeutic strategy for breast cancer. This article reviews the abnormal metabolism of breast cancer cells and its impact on the anti-tumor activity of T cells, and further explores the possibility of targeting metabolism as a therapeutic strategy for breast cancer. |
| first_indexed | 2024-04-24T10:59:22Z |
| format | Article |
| id | doaj.art-1b9b5d044a214d948b9d1593f754ba3a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T10:59:22Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1b9b5d044a214d948b9d1593f754ba3a2024-04-12T04:14:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-04-011510.3389/fimmu.2024.13819701381970Targeting metabolism of breast cancer and its implications in T cell immunotherapyJialuo Zou0Cunjun Mai1Zhiqin Lin2Jian Zhou3Guie Lai4Department of Breast Disease Comprehensive Center, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Breast Disease Comprehensive Center, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Breast Disease Comprehensive Center, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Immunology, International Cancer Center, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, Guangdong, ChinaDepartment of Breast Disease Comprehensive Center, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi, ChinaBreast cancer is a prominent health issue amongst women around the world. Immunotherapies including tumor targeted antibodies, adoptive T cell therapy, vaccines, and immune checkpoint blockers have rejuvenated the clinical management of breast cancer, but the prognosis of patients remains dismal. Metabolic reprogramming and immune escape are two important mechanisms supporting the progression of breast cancer. The deprivation uptake of nutrients (such as glucose, amino acid, and lipid) by breast cancer cells has a significant impact on tumor growth and microenvironment remodeling. In recent years, in-depth researches on the mechanism of metabolic reprogramming and immune escape have been extensively conducted, and targeting metabolic reprogramming has been proposed as a new therapeutic strategy for breast cancer. This article reviews the abnormal metabolism of breast cancer cells and its impact on the anti-tumor activity of T cells, and further explores the possibility of targeting metabolism as a therapeutic strategy for breast cancer.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1381970/fullbreast cancerT cell immunotherapymetabolic reprogrammingimmune escapeglucoseamino acid |
| spellingShingle | Jialuo Zou Cunjun Mai Zhiqin Lin Jian Zhou Guie Lai Targeting metabolism of breast cancer and its implications in T cell immunotherapy Frontiers in Immunology breast cancer T cell immunotherapy metabolic reprogramming immune escape glucose amino acid |
| title | Targeting metabolism of breast cancer and its implications in T cell immunotherapy |
| title_full | Targeting metabolism of breast cancer and its implications in T cell immunotherapy |
| title_fullStr | Targeting metabolism of breast cancer and its implications in T cell immunotherapy |
| title_full_unstemmed | Targeting metabolism of breast cancer and its implications in T cell immunotherapy |
| title_short | Targeting metabolism of breast cancer and its implications in T cell immunotherapy |
| title_sort | targeting metabolism of breast cancer and its implications in t cell immunotherapy |
| topic | breast cancer T cell immunotherapy metabolic reprogramming immune escape glucose amino acid |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1381970/full |
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