To exploring the role of probiotics, plant-based fermented products, and paraprobiotics as anti-inflammatory agents in promoting human health
Inflammation is a complex response to tissue damage and pathogens that can lead to chronic inflammatory disorders and various health complications. Conventional inflammation treatments have limitations, driving the search for alternative approaches. Probiotics have gained attention for their immunom...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Journal of Agriculture and Food Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666154323004039 |
| _version_ | 1797385066392846336 |
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| author | Harsh Kumar Rajni Dhalaria Shivani Guleria Richard Cimler Rajni Choudhary Daljeet Singh Dhanjal Reena Singh Neetika Kimta Kanika Dulta Ashok Kumar Pathera Azhar Khan Mohammad Nausad Suliman Y. Alomar Sivakumar Manickam Kamil Kuča |
| author_facet | Harsh Kumar Rajni Dhalaria Shivani Guleria Richard Cimler Rajni Choudhary Daljeet Singh Dhanjal Reena Singh Neetika Kimta Kanika Dulta Ashok Kumar Pathera Azhar Khan Mohammad Nausad Suliman Y. Alomar Sivakumar Manickam Kamil Kuča |
| author_sort | Harsh Kumar |
| collection | DOAJ |
| description | Inflammation is a complex response to tissue damage and pathogens that can lead to chronic inflammatory disorders and various health complications. Conventional inflammation treatments have limitations, driving the search for alternative approaches. Probiotics have gained attention for their immunomodulatory properties, while paraprobiotics have emerged as a promising anti-inflammatory strategy. Probiotics like Lactobacillus, Bifidobacterium, Saccharomyces, and Bacillus can interact with immune cells through toll-like receptors, triggering the synthesis of anti-inflammatory cytokines and promoting immune cell differentiation. Studies carried out in vivo revealed that TNF- α, TRL4, and NF-κB were downregulated by Lactobacilli species. In contrast, Bifidobacterium species elevated IL-10 and Foxp3. This helps maintain immune balance and reduce hyperinflammatory responses. Probiotic plant-based fermented products also suppressed NF-κB signalling activation and decreased iNOS and COX-2 synthesis. Paraprobiotics, on the other hand, exhibit anti-inflammatory properties and have shown promising results in regulating immune responses and alleviating symptoms in specific inflammatory conditions. They may address concerns related to the viability and safety of live probiotics. This review emphasizes the potential of probiotics, probiotic plant-based fermented products, and paraprobiotics as therapeutic agents for managing inflammatory disorders arising from malnutrition, gut diseases, cardiovascular disease, and neurological disorders. It discusses in-vitro, in-vivo, and human studies highlighting the role of different probiotic strains, commercially available probiotics, challenges with probiotics, probiotic plant-based fermented products, and paraprobiotics in combating inflammation. |
| first_indexed | 2024-03-08T21:47:49Z |
| format | Article |
| id | doaj.art-1b9cf362db1c43f7bcf1f171e6146a8a |
| institution | Directory Open Access Journal |
| issn | 2666-1543 |
| language | English |
| last_indexed | 2024-03-08T21:47:49Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Agriculture and Food Research |
| spelling | doaj.art-1b9cf362db1c43f7bcf1f171e6146a8a2023-12-20T07:37:52ZengElsevierJournal of Agriculture and Food Research2666-15432023-12-0114100896To exploring the role of probiotics, plant-based fermented products, and paraprobiotics as anti-inflammatory agents in promoting human healthHarsh Kumar0Rajni Dhalaria1Shivani Guleria2Richard Cimler3Rajni Choudhary4Daljeet Singh Dhanjal5Reena Singh6Neetika Kimta7Kanika Dulta8Ashok Kumar Pathera9Azhar Khan10Mohammad Nausad11Suliman Y. Alomar12Sivakumar Manickam13Kamil Kuča14Centre of Advanced Technologies, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech RepublicSchool of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, IndiaDepartment of Biotechnology, TIFAC-Centre of Relevance and Excellence in Agro and Industrial Biotechnology (CORE), Thapar Institute of Engineering and Technology, Patiala, 147001, IndiaCentre of Advanced Technologies, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech RepublicSchool of Health Sciences & Technology, University of Petroleum and Energy Studies, Dehradun, 248007, Uttarakhand, IndiaSchool of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, 144411, IndiaSchool of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, 144411, IndiaSchool of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, IndiaDepartment of Food Technology, School of Applied and Life Sciences, Uttaranchal University, Dehradun, 248007, Uttarakhand, IndiaAmity Institute of Food Technology, Amity University, Noida, 201313, IndiaFaculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, IndiaUniv. Bourgogne Franche-Comté, AgroSup Dijon, PAM UMR A 02.102, F-21000, Dijon, FranceZoology Department, King Saud University, College of Science, Riyadh, 11451, Saudi ArabiaPetroleum and Chemical Engineering, Faculty of Engineering, Universiti Teknologi Brunei, Bandar, Seri Begawan, BE1410, Brunei; Corresponding author.Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003, Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic; Corresponding author.Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003, Hradec Kralove, Czech RepublicInflammation is a complex response to tissue damage and pathogens that can lead to chronic inflammatory disorders and various health complications. Conventional inflammation treatments have limitations, driving the search for alternative approaches. Probiotics have gained attention for their immunomodulatory properties, while paraprobiotics have emerged as a promising anti-inflammatory strategy. Probiotics like Lactobacillus, Bifidobacterium, Saccharomyces, and Bacillus can interact with immune cells through toll-like receptors, triggering the synthesis of anti-inflammatory cytokines and promoting immune cell differentiation. Studies carried out in vivo revealed that TNF- α, TRL4, and NF-κB were downregulated by Lactobacilli species. In contrast, Bifidobacterium species elevated IL-10 and Foxp3. This helps maintain immune balance and reduce hyperinflammatory responses. Probiotic plant-based fermented products also suppressed NF-κB signalling activation and decreased iNOS and COX-2 synthesis. Paraprobiotics, on the other hand, exhibit anti-inflammatory properties and have shown promising results in regulating immune responses and alleviating symptoms in specific inflammatory conditions. They may address concerns related to the viability and safety of live probiotics. This review emphasizes the potential of probiotics, probiotic plant-based fermented products, and paraprobiotics as therapeutic agents for managing inflammatory disorders arising from malnutrition, gut diseases, cardiovascular disease, and neurological disorders. It discusses in-vitro, in-vivo, and human studies highlighting the role of different probiotic strains, commercially available probiotics, challenges with probiotics, probiotic plant-based fermented products, and paraprobiotics in combating inflammation.http://www.sciencedirect.com/science/article/pii/S2666154323004039LactobacillusGut microbiotaHuman healthNon-viable bacteriaPolyphenols |
| spellingShingle | Harsh Kumar Rajni Dhalaria Shivani Guleria Richard Cimler Rajni Choudhary Daljeet Singh Dhanjal Reena Singh Neetika Kimta Kanika Dulta Ashok Kumar Pathera Azhar Khan Mohammad Nausad Suliman Y. Alomar Sivakumar Manickam Kamil Kuča To exploring the role of probiotics, plant-based fermented products, and paraprobiotics as anti-inflammatory agents in promoting human health Journal of Agriculture and Food Research Lactobacillus Gut microbiota Human health Non-viable bacteria Polyphenols |
| title | To exploring the role of probiotics, plant-based fermented products, and paraprobiotics as anti-inflammatory agents in promoting human health |
| title_full | To exploring the role of probiotics, plant-based fermented products, and paraprobiotics as anti-inflammatory agents in promoting human health |
| title_fullStr | To exploring the role of probiotics, plant-based fermented products, and paraprobiotics as anti-inflammatory agents in promoting human health |
| title_full_unstemmed | To exploring the role of probiotics, plant-based fermented products, and paraprobiotics as anti-inflammatory agents in promoting human health |
| title_short | To exploring the role of probiotics, plant-based fermented products, and paraprobiotics as anti-inflammatory agents in promoting human health |
| title_sort | to exploring the role of probiotics plant based fermented products and paraprobiotics as anti inflammatory agents in promoting human health |
| topic | Lactobacillus Gut microbiota Human health Non-viable bacteria Polyphenols |
| url | http://www.sciencedirect.com/science/article/pii/S2666154323004039 |
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