Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB

Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB

Reduced expression of brain-derived neurotrophic factor (BDNF) and impaired activation of the BDNF receptor, tropomyosin receptor kinase B (TrkB; also known as Ntrk2), are thought to contribute significantly to the pathophysiology of Rett syndrome (RTT), a severe neurodevelopmental disorder caused b...

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Bibliographic Details
Main Authors: Ian Adams, Tao Yang, Frank M. Longo, David M. Katz
Format: Article
Language:English
Published: The Company of Biologists 2020-11-01
Series:Disease Models & Mechanisms
Subjects:
mecp2
brain-derived neurotrophic factor
neuro-rehabilitation
respiration
Online Access:http://dmm.biologists.org/content/13/11/dmm044685

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