Genomic evolution of cancer metastasis under therapeutic pressure
Abstract In the era of precision medicine, the selection of cancer treatment relies increasingly on the identification of genomic alterations; however, it is not yet clear how frequently genomic profiling should be performed over the disease course of a patient with metastatic cancer. A large‐scale...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
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| Series: | MedComm – Oncology |
| Online Access: | https://doi.org/10.1002/mog2.5 |
| _version_ | 1797829184379158528 |
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| author | Qiu‐Luo Liu Xi Li Hai‐Ning Chen |
| author_facet | Qiu‐Luo Liu Xi Li Hai‐Ning Chen |
| author_sort | Qiu‐Luo Liu |
| collection | DOAJ |
| description | Abstract In the era of precision medicine, the selection of cancer treatment relies increasingly on the identification of genomic alterations; however, it is not yet clear how frequently genomic profiling should be performed over the disease course of a patient with metastatic cancer. A large‐scale study investigates the genomic evolution of cancer metastases under therapeutic pressure and finds that the actionable genome has remained relatively stable. The findings support the sufficiency of a single biopsy of cancer metastasis for therapeutic decision‐making. |
| first_indexed | 2024-04-09T13:16:22Z |
| format | Article |
| id | doaj.art-1b9dd36fe788400ea9eea602476e0d2d |
| institution | Directory Open Access Journal |
| issn | 2769-6448 |
| language | English |
| last_indexed | 2024-04-09T13:16:22Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Oncology |
| spelling | doaj.art-1b9dd36fe788400ea9eea602476e0d2d2023-05-11T17:25:30ZengWileyMedComm – Oncology2769-64482022-06-0111n/an/a10.1002/mog2.5Genomic evolution of cancer metastasis under therapeutic pressureQiu‐Luo Liu0Xi Li1Hai‐Ning Chen2Department of Gastrointestinal Surgery, West China Hospital Sichuan University Chengdu Sichuan PR ChinaColorectal Surgery Unit, Department of General Surgery, Addenbrooke's Hospital Cambridge University Hospitals NHS Foundation Trust Cambridge UKDepartment of Gastrointestinal Surgery, West China Hospital Sichuan University Chengdu Sichuan PR ChinaAbstract In the era of precision medicine, the selection of cancer treatment relies increasingly on the identification of genomic alterations; however, it is not yet clear how frequently genomic profiling should be performed over the disease course of a patient with metastatic cancer. A large‐scale study investigates the genomic evolution of cancer metastases under therapeutic pressure and finds that the actionable genome has remained relatively stable. The findings support the sufficiency of a single biopsy of cancer metastasis for therapeutic decision‐making.https://doi.org/10.1002/mog2.5 |
| spellingShingle | Qiu‐Luo Liu Xi Li Hai‐Ning Chen Genomic evolution of cancer metastasis under therapeutic pressure MedComm – Oncology |
| title | Genomic evolution of cancer metastasis under therapeutic pressure |
| title_full | Genomic evolution of cancer metastasis under therapeutic pressure |
| title_fullStr | Genomic evolution of cancer metastasis under therapeutic pressure |
| title_full_unstemmed | Genomic evolution of cancer metastasis under therapeutic pressure |
| title_short | Genomic evolution of cancer metastasis under therapeutic pressure |
| title_sort | genomic evolution of cancer metastasis under therapeutic pressure |
| url | https://doi.org/10.1002/mog2.5 |
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