Remission of a Primary, Recurrent Thoracic Ewing Sarcoma in a 74-year-old woman
Ewing sarcoma is a primitive neuroectodermal tumor which seldom presents with primary disease in people over age 40 and outside of the appendicular or axial skeleton. We examine a case of primary thoracic Ewing Sarcoma diagnosed initially by CT-guided biopsy in a woman at the age of 74 years. The di...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-06-01
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| Series: | Rare Tumors |
| Online Access: | https://doi.org/10.1177/20363613221110836 |
| _version_ | 1811324970192601088 |
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| author | Robert M. Tungate MD Kristi Lara PA-C Dakshesh Patel MD Alexander Fedenko MD James Hu MD |
| author_facet | Robert M. Tungate MD Kristi Lara PA-C Dakshesh Patel MD Alexander Fedenko MD James Hu MD |
| author_sort | Robert M. Tungate MD |
| collection | DOAJ |
| description | Ewing sarcoma is a primitive neuroectodermal tumor which seldom presents with primary disease in people over age 40 and outside of the appendicular or axial skeleton. We examine a case of primary thoracic Ewing Sarcoma diagnosed initially by CT-guided biopsy in a woman at the age of 74 years. The disease progressed after initial combined modality therapy consisting of neoadjuvant chemotherapy, surgical resection, and adjuvant radiation therapy and two additional courses of multiagent chemotherapy. After relapse of her disease, subsequent second- and third-line systemic agents which included chemotherapy and targeted agents were given with disease stabilization achieved now over 30 months from initial diagnosis. To our knowledge, this is the first report of a primary pulmonary Ewing sarcoma diagnosed in a patient greater than 70 years of age in whom multiple remissions have been achieved with tolerable toxicities. |
| first_indexed | 2024-04-13T14:24:50Z |
| format | Article |
| id | doaj.art-1ba0ad26c20b437d88492900fc61348d |
| institution | Directory Open Access Journal |
| issn | 2036-3613 |
| language | English |
| last_indexed | 2024-04-13T14:24:50Z |
| publishDate | 2022-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-1ba0ad26c20b437d88492900fc61348d2022-12-22T02:43:21ZengSAGE PublishingRare Tumors2036-36132022-06-011410.1177/20363613221110836Remission of a Primary, Recurrent Thoracic Ewing Sarcoma in a 74-year-old womanRobert M. Tungate MDKristi Lara PA-CDakshesh Patel MDAlexander Fedenko MDJames Hu MDEwing sarcoma is a primitive neuroectodermal tumor which seldom presents with primary disease in people over age 40 and outside of the appendicular or axial skeleton. We examine a case of primary thoracic Ewing Sarcoma diagnosed initially by CT-guided biopsy in a woman at the age of 74 years. The disease progressed after initial combined modality therapy consisting of neoadjuvant chemotherapy, surgical resection, and adjuvant radiation therapy and two additional courses of multiagent chemotherapy. After relapse of her disease, subsequent second- and third-line systemic agents which included chemotherapy and targeted agents were given with disease stabilization achieved now over 30 months from initial diagnosis. To our knowledge, this is the first report of a primary pulmonary Ewing sarcoma diagnosed in a patient greater than 70 years of age in whom multiple remissions have been achieved with tolerable toxicities.https://doi.org/10.1177/20363613221110836 |
| spellingShingle | Robert M. Tungate MD Kristi Lara PA-C Dakshesh Patel MD Alexander Fedenko MD James Hu MD Remission of a Primary, Recurrent Thoracic Ewing Sarcoma in a 74-year-old woman Rare Tumors |
| title | Remission of a Primary, Recurrent Thoracic Ewing Sarcoma in a 74-year-old woman |
| title_full | Remission of a Primary, Recurrent Thoracic Ewing Sarcoma in a 74-year-old woman |
| title_fullStr | Remission of a Primary, Recurrent Thoracic Ewing Sarcoma in a 74-year-old woman |
| title_full_unstemmed | Remission of a Primary, Recurrent Thoracic Ewing Sarcoma in a 74-year-old woman |
| title_short | Remission of a Primary, Recurrent Thoracic Ewing Sarcoma in a 74-year-old woman |
| title_sort | remission of a primary recurrent thoracic ewing sarcoma in a 74 year old woman |
| url | https://doi.org/10.1177/20363613221110836 |
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