Leptin replacement improves cognitive development.
Leptin changes brain structure, neuron excitability and synaptic plasticity. It also regulates the development and function of feeding circuits. However, the effects of leptin on neurocognitive development are unknown.To evaluate the effect of leptin on neurocognitive development.A 5-year-old boy wi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2008-08-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2518120?pdf=render |
| _version_ | 1811306356032929792 |
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| author | Gilberto J Paz-Filho Talin Babikian Robert Asarnow Tuncay Delibasi Karin Esposito Halil K Erol Ma-Li Wong Julio Licinio |
| author_facet | Gilberto J Paz-Filho Talin Babikian Robert Asarnow Tuncay Delibasi Karin Esposito Halil K Erol Ma-Li Wong Julio Licinio |
| author_sort | Gilberto J Paz-Filho |
| collection | DOAJ |
| description | Leptin changes brain structure, neuron excitability and synaptic plasticity. It also regulates the development and function of feeding circuits. However, the effects of leptin on neurocognitive development are unknown.To evaluate the effect of leptin on neurocognitive development.A 5-year-old boy with a nonconservative missense leptin gene mutation (Cys-to-Thr in codon 105) was treated with recombinant methionyl human leptin (r-metHuLeptin) at physiologic replacement doses of 0.03 mg/kg/day. Cognitive development was assessed using the Differential Ability Scales (DAS), a measure of general verbal and nonverbal functioning; and selected subtests from the NEPSY, a measure of neuropsychological functioning in children.Prior to treatment, the patient was morbidly obese, hypertensive, dyslipidemic, and hyperinsulinemic. Baseline neurocognitive tests revealed slower than expected rates of development (developmental age lower than chronological age) in a majority of the areas assessed. After two years, substantial increases in the rates of development in most neurocognitive domains were apparent, with some skills at or exceeding expectations based on chronological age. We also observed marked weight loss and resolution of hypertension, dyslipidemia and hyperinsulinemia.We concluded that replacement with r-metHuLeptin is associated with weight loss and changes in rates of development in many neurocognitive domains, which lends support to the hypothesis that, in addition to its role in metabolism, leptin may have a cognitive enhancing role in the developing central nervous system.ClinicalTrials.gov NCT00659828. |
| first_indexed | 2024-04-13T08:43:00Z |
| format | Article |
| id | doaj.art-1ba19230930e4046aa6f2a898127d70a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T08:43:00Z |
| publishDate | 2008-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1ba19230930e4046aa6f2a898127d70a2022-12-22T02:53:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032008-08-0138e309810.1371/journal.pone.0003098Leptin replacement improves cognitive development.Gilberto J Paz-FilhoTalin BabikianRobert AsarnowTuncay DelibasiKarin EspositoHalil K ErolMa-Li WongJulio LicinioLeptin changes brain structure, neuron excitability and synaptic plasticity. It also regulates the development and function of feeding circuits. However, the effects of leptin on neurocognitive development are unknown.To evaluate the effect of leptin on neurocognitive development.A 5-year-old boy with a nonconservative missense leptin gene mutation (Cys-to-Thr in codon 105) was treated with recombinant methionyl human leptin (r-metHuLeptin) at physiologic replacement doses of 0.03 mg/kg/day. Cognitive development was assessed using the Differential Ability Scales (DAS), a measure of general verbal and nonverbal functioning; and selected subtests from the NEPSY, a measure of neuropsychological functioning in children.Prior to treatment, the patient was morbidly obese, hypertensive, dyslipidemic, and hyperinsulinemic. Baseline neurocognitive tests revealed slower than expected rates of development (developmental age lower than chronological age) in a majority of the areas assessed. After two years, substantial increases in the rates of development in most neurocognitive domains were apparent, with some skills at or exceeding expectations based on chronological age. We also observed marked weight loss and resolution of hypertension, dyslipidemia and hyperinsulinemia.We concluded that replacement with r-metHuLeptin is associated with weight loss and changes in rates of development in many neurocognitive domains, which lends support to the hypothesis that, in addition to its role in metabolism, leptin may have a cognitive enhancing role in the developing central nervous system.ClinicalTrials.gov NCT00659828.http://europepmc.org/articles/PMC2518120?pdf=render |
| spellingShingle | Gilberto J Paz-Filho Talin Babikian Robert Asarnow Tuncay Delibasi Karin Esposito Halil K Erol Ma-Li Wong Julio Licinio Leptin replacement improves cognitive development. PLoS ONE |
| title | Leptin replacement improves cognitive development. |
| title_full | Leptin replacement improves cognitive development. |
| title_fullStr | Leptin replacement improves cognitive development. |
| title_full_unstemmed | Leptin replacement improves cognitive development. |
| title_short | Leptin replacement improves cognitive development. |
| title_sort | leptin replacement improves cognitive development |
| url | http://europepmc.org/articles/PMC2518120?pdf=render |
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