Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids
Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer’s disease, schizophrenia, a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/1/507 |
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| author | Ewa Szczurowska Eszter Szánti-Pintér Nikolai Chetverikov Alena Randáková Eva Kudová Jan Jakubík |
| author_facet | Ewa Szczurowska Eszter Szánti-Pintér Nikolai Chetverikov Alena Randáková Eva Kudová Jan Jakubík |
| author_sort | Ewa Szczurowska |
| collection | DOAJ |
| description | Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer’s disease, schizophrenia, addiction, epilepsy, or depression. Muscarinic receptors are allosterically modulated by neurosteroids and steroid hormones at physiologically relevant concentrations. In this review, we focus on the modulation of muscarinic receptors by neurosteroids and steroid hormones in the context of diseases and disorders of the central nervous system. Further, we propose the potential use of neuroactive steroids in the development of pharmacotherapeutics for these diseases and conditions. |
| first_indexed | 2024-03-11T09:58:35Z |
| format | Article |
| id | doaj.art-1ba22ba0a7a84192b0a6a42c5d1c8e16 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:58:35Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1ba22ba0a7a84192b0a6a42c5d1c8e162023-11-16T15:34:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124150710.3390/ijms24010507Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and NeurosteroidsEwa Szczurowska0Eszter Szánti-Pintér1Nikolai Chetverikov2Alena Randáková3Eva Kudová4Jan Jakubík5Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo Náměstí 2, Prague 6, 166 10 Prague, Czech RepublicInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo Náměstí 2, Prague 6, 166 10 Prague, Czech RepublicInstitute of Physiology, Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech RepublicInstitute of Physiology, Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech RepublicInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo Náměstí 2, Prague 6, 166 10 Prague, Czech RepublicInstitute of Physiology, Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech RepublicMuscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer’s disease, schizophrenia, addiction, epilepsy, or depression. Muscarinic receptors are allosterically modulated by neurosteroids and steroid hormones at physiologically relevant concentrations. In this review, we focus on the modulation of muscarinic receptors by neurosteroids and steroid hormones in the context of diseases and disorders of the central nervous system. Further, we propose the potential use of neuroactive steroids in the development of pharmacotherapeutics for these diseases and conditions.https://www.mdpi.com/1422-0067/24/1/507neurosteroidsneuroactive steroidscholesterolmuscarinic receptorsAlzheimer’s diseaseParkinson’s disease |
| spellingShingle | Ewa Szczurowska Eszter Szánti-Pintér Nikolai Chetverikov Alena Randáková Eva Kudová Jan Jakubík Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids International Journal of Molecular Sciences neurosteroids neuroactive steroids cholesterol muscarinic receptors Alzheimer’s disease Parkinson’s disease |
| title | Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids |
| title_full | Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids |
| title_fullStr | Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids |
| title_full_unstemmed | Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids |
| title_short | Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids |
| title_sort | modulation of muscarinic signalling in the central nervous system by steroid hormones and neurosteroids |
| topic | neurosteroids neuroactive steroids cholesterol muscarinic receptors Alzheimer’s disease Parkinson’s disease |
| url | https://www.mdpi.com/1422-0067/24/1/507 |
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