Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration
Growth factors are bio-factors that target reparatory cells during bone regeneration. These growth factors are needed in complicated conditions of bone and joint damage to enhance tissue repair. The delivery of these growth factors is key to ensuring the effectiveness of regenerative therapy. This r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/9/5/223 |
| _version_ | 1797501491077971968 |
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| author | Sheeba Shakoor Eleyna Kibble Jehan J. El-Jawhari |
| author_facet | Sheeba Shakoor Eleyna Kibble Jehan J. El-Jawhari |
| author_sort | Sheeba Shakoor |
| collection | DOAJ |
| description | Growth factors are bio-factors that target reparatory cells during bone regeneration. These growth factors are needed in complicated conditions of bone and joint damage to enhance tissue repair. The delivery of these growth factors is key to ensuring the effectiveness of regenerative therapy. This review discusses the roles of various growth factors in bone and cartilage regeneration. The methods of delivery of natural or recombinant growth factors are reviewed. Different types of scaffolds, encapsulation, Layer-by-layer assembly, and hydrogels are tools for growth factor delivery. Considering the advantages and limitations of these methods is essential to developing regenerative therapies. Further research can accordingly be planned to have new or combined technologies serving this purpose. |
| first_indexed | 2024-03-10T03:19:10Z |
| format | Article |
| id | doaj.art-1ba6212cdb4647cabd197f533c09dc1d |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T03:19:10Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-1ba6212cdb4647cabd197f533c09dc1d2023-11-23T10:05:58ZengMDPI AGBioengineering2306-53542022-05-019522310.3390/bioengineering9050223Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage RegenerationSheeba Shakoor0Eleyna Kibble1Jehan J. El-Jawhari2Biosciences Department, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8PT, UKBiosciences Department, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8PT, UKBiosciences Department, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8PT, UKGrowth factors are bio-factors that target reparatory cells during bone regeneration. These growth factors are needed in complicated conditions of bone and joint damage to enhance tissue repair. The delivery of these growth factors is key to ensuring the effectiveness of regenerative therapy. This review discusses the roles of various growth factors in bone and cartilage regeneration. The methods of delivery of natural or recombinant growth factors are reviewed. Different types of scaffolds, encapsulation, Layer-by-layer assembly, and hydrogels are tools for growth factor delivery. Considering the advantages and limitations of these methods is essential to developing regenerative therapies. Further research can accordingly be planned to have new or combined technologies serving this purpose.https://www.mdpi.com/2306-5354/9/5/223growth factorsbonecartilageregeneration |
| spellingShingle | Sheeba Shakoor Eleyna Kibble Jehan J. El-Jawhari Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration Bioengineering growth factors bone cartilage regeneration |
| title | Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration |
| title_full | Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration |
| title_fullStr | Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration |
| title_full_unstemmed | Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration |
| title_short | Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration |
| title_sort | bioengineering approaches for delivering growth factors a focus on bone and cartilage regeneration |
| topic | growth factors bone cartilage regeneration |
| url | https://www.mdpi.com/2306-5354/9/5/223 |
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