Antagonistic Effects of CAPE (a Component of Propolis) on the Cytotoxicity and Genotoxicity of Irinotecan and SN38 in Human Gastrointestinal Cancer Cells In Vitro

Antagonistic Effects of CAPE (a Component of Propolis) on the Cytotoxicity and Genotoxicity of Irinotecan and SN38 in Human Gastrointestinal Cancer Cells In Vitro

The incidence of gastrointestinal cancers is increasing every year. Irinotecan (CPT-11), a drug used in the treatment of colorectal cancer and gastric cancer, is metabolized by carboxylesterases to an active metabolite, SN-38, which is more cytotoxic. CAPE (caffeic acid phenethyl ester) is an active...

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Bibliographic Details
Main Authors: Gabriela Gajek, Beata Marciniak, Jarosław Lewkowski, Renata Kontek
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
cape
irinotecan
sn38
cytotoxicity
genotoxicity
oxidative stress
Online Access:https://www.mdpi.com/1420-3049/25/3/658

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