Microwave-Assisted Synthesis of Tri-Substituted 1,3,5-Triazines from Metformin Using Benzotriazole Chemistry
A simple, metal-free, cost-effective, and eco-friendly protocol for the preparation of trisubstituted 1,3,5 triazine from metformin using benzotriazole chemistry is reported. Short reaction time, large-scale synthesis, easy and quick isolation of the product, and excellent yield are the main advanta...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Reactions |
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| Online Access: | https://www.mdpi.com/2624-781X/3/4/34 |
| _version_ | 1827637068944113664 |
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| author | Siva S. Panda Eyana Thomas Ashley M. Pham |
| author_facet | Siva S. Panda Eyana Thomas Ashley M. Pham |
| author_sort | Siva S. Panda |
| collection | DOAJ |
| description | A simple, metal-free, cost-effective, and eco-friendly protocol for the preparation of trisubstituted 1,3,5 triazine from metformin using benzotriazole chemistry is reported. Short reaction time, large-scale synthesis, easy and quick isolation of the product, and excellent yield are the main advantages of this procedure. Furthermore, the use of benzotriazole chemistry results in a product free from metal traces. Our optimized reaction condition and methodology overcome the challenges of using a metal catalyst, such as a longer reaction time, lower yields, and expensive starting materials. |
| first_indexed | 2024-03-09T15:54:11Z |
| format | Article |
| id | doaj.art-1ba721aadd58473da7bfcf56ee1c1736 |
| institution | Directory Open Access Journal |
| issn | 2624-781X |
| language | English |
| last_indexed | 2024-03-09T15:54:11Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Reactions |
| spelling | doaj.art-1ba721aadd58473da7bfcf56ee1c17362023-11-24T17:43:29ZengMDPI AGReactions2624-781X2022-10-013451652410.3390/reactions3040034Microwave-Assisted Synthesis of Tri-Substituted 1,3,5-Triazines from Metformin Using Benzotriazole ChemistrySiva S. Panda0Eyana Thomas1Ashley M. Pham2Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USADepartment of Chemistry and Physics, Augusta University, Augusta, GA 30912, USADepartment of Chemistry and Physics, Augusta University, Augusta, GA 30912, USAA simple, metal-free, cost-effective, and eco-friendly protocol for the preparation of trisubstituted 1,3,5 triazine from metformin using benzotriazole chemistry is reported. Short reaction time, large-scale synthesis, easy and quick isolation of the product, and excellent yield are the main advantages of this procedure. Furthermore, the use of benzotriazole chemistry results in a product free from metal traces. Our optimized reaction condition and methodology overcome the challenges of using a metal catalyst, such as a longer reaction time, lower yields, and expensive starting materials.https://www.mdpi.com/2624-781X/3/4/34metformin1,3,5-triazinebenzotriazolesynthesismicrowave |
| spellingShingle | Siva S. Panda Eyana Thomas Ashley M. Pham Microwave-Assisted Synthesis of Tri-Substituted 1,3,5-Triazines from Metformin Using Benzotriazole Chemistry Reactions metformin 1,3,5-triazine benzotriazole synthesis microwave |
| title | Microwave-Assisted Synthesis of Tri-Substituted 1,3,5-Triazines from Metformin Using Benzotriazole Chemistry |
| title_full | Microwave-Assisted Synthesis of Tri-Substituted 1,3,5-Triazines from Metformin Using Benzotriazole Chemistry |
| title_fullStr | Microwave-Assisted Synthesis of Tri-Substituted 1,3,5-Triazines from Metformin Using Benzotriazole Chemistry |
| title_full_unstemmed | Microwave-Assisted Synthesis of Tri-Substituted 1,3,5-Triazines from Metformin Using Benzotriazole Chemistry |
| title_short | Microwave-Assisted Synthesis of Tri-Substituted 1,3,5-Triazines from Metformin Using Benzotriazole Chemistry |
| title_sort | microwave assisted synthesis of tri substituted 1 3 5 triazines from metformin using benzotriazole chemistry |
| topic | metformin 1,3,5-triazine benzotriazole synthesis microwave |
| url | https://www.mdpi.com/2624-781X/3/4/34 |
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