SPECIFIC FEATURE OF HORMONAL PROFILE IN PATIENTS WITH PRIMARY AND RECURRENT BREAST CANCER AND THEIR ROLE IN THE EFFICIENCY OF CHEMOTHERAPY
The hormonal background was studied in 32 menopausal patients who had primary breast cancer (Stage III) or its recurrence in the postoperative scar. The patients with the primary process, unlike those with a recurrence, were found to have increased adrenocortical cortisol-forming activity and change...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2014-09-01
|
| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/286 |
| _version_ | 1826557319004028928 |
|---|---|
| author | M. B. Kozlova E. M. Frantziyantz G. A. Nerodo R. N. Salatov R. G. Luganskaya I. P. Sidorenko M. V. Kashubina |
| author_facet | M. B. Kozlova E. M. Frantziyantz G. A. Nerodo R. N. Salatov R. G. Luganskaya I. P. Sidorenko M. V. Kashubina |
| author_sort | M. B. Kozlova |
| collection | DOAJ |
| description | The hormonal background was studied in 32 menopausal patients who had primary breast cancer (Stage III) or its recurrence in the postoperative scar. The patients with the primary process, unlike those with a recurrence, were found to have increased adrenocortical cortisol-forming activity and changed thyroid homeostasis. In both types of the neoplastic process, the blood concentrations of estradi- ol, testosterone, prolactin, follicle-stimulating and luteinizing hormones were disturbed in a substantial number of cases; the distinc- tive feature of the primary process and its recurrence lies in the opposite direction. An association of individual differences in the con- centrations of estradiol and testosterone with the efficiency of neoadjuvant chemotherapy was analyzed in patients with recurrent can- cer. |
| first_indexed | 2024-04-10T01:57:14Z |
| format | Article |
| id | doaj.art-1ba812dcc41e42aca9e102fe13370335 |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2025-03-14T08:26:42Z |
| publishDate | 2014-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-1ba812dcc41e42aca9e102fe133703352025-03-02T13:05:31ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-09-0101-2293310.17650/1994-4098-2009-0-1-2-29-33302SPECIFIC FEATURE OF HORMONAL PROFILE IN PATIENTS WITH PRIMARY AND RECURRENT BREAST CANCER AND THEIR ROLE IN THE EFFICIENCY OF CHEMOTHERAPYM. B. Kozlova0E. M. Frantziyantz1G. A. Nerodo2R. N. Salatov3R. G. Luganskaya4I. P. Sidorenko5M. V. Kashubina6Rostov Cancer Research Institute, Russian Agency for Medical TechnologiesRostov Cancer Research Institute, Russian Agency for Medical TechnologiesRostov Cancer Research Institute, Russian Agency for Medical TechnologiesRostov Cancer Research Institute, Russian Agency for Medical TechnologiesRostov Cancer Research Institute, Russian Agency for Medical TechnologiesRostov Cancer Research Institute, Russian Agency for Medical TechnologiesRostov Cancer Research Institute, Russian Agency for Medical TechnologiesThe hormonal background was studied in 32 menopausal patients who had primary breast cancer (Stage III) or its recurrence in the postoperative scar. The patients with the primary process, unlike those with a recurrence, were found to have increased adrenocortical cortisol-forming activity and changed thyroid homeostasis. In both types of the neoplastic process, the blood concentrations of estradi- ol, testosterone, prolactin, follicle-stimulating and luteinizing hormones were disturbed in a substantial number of cases; the distinc- tive feature of the primary process and its recurrence lies in the opposite direction. An association of individual differences in the con- centrations of estradiol and testosterone with the efficiency of neoadjuvant chemotherapy was analyzed in patients with recurrent can- cer.https://ojrs.abvpress.ru/ojrs/article/view/286breast cancerrecurrencehormonal profilechemotherapy |
| spellingShingle | M. B. Kozlova E. M. Frantziyantz G. A. Nerodo R. N. Salatov R. G. Luganskaya I. P. Sidorenko M. V. Kashubina SPECIFIC FEATURE OF HORMONAL PROFILE IN PATIENTS WITH PRIMARY AND RECURRENT BREAST CANCER AND THEIR ROLE IN THE EFFICIENCY OF CHEMOTHERAPY Опухоли женской репродуктивной системы breast cancer recurrence hormonal profile chemotherapy |
| title | SPECIFIC FEATURE OF HORMONAL PROFILE IN PATIENTS WITH PRIMARY AND RECURRENT BREAST CANCER AND THEIR ROLE IN THE EFFICIENCY OF CHEMOTHERAPY |
| title_full | SPECIFIC FEATURE OF HORMONAL PROFILE IN PATIENTS WITH PRIMARY AND RECURRENT BREAST CANCER AND THEIR ROLE IN THE EFFICIENCY OF CHEMOTHERAPY |
| title_fullStr | SPECIFIC FEATURE OF HORMONAL PROFILE IN PATIENTS WITH PRIMARY AND RECURRENT BREAST CANCER AND THEIR ROLE IN THE EFFICIENCY OF CHEMOTHERAPY |
| title_full_unstemmed | SPECIFIC FEATURE OF HORMONAL PROFILE IN PATIENTS WITH PRIMARY AND RECURRENT BREAST CANCER AND THEIR ROLE IN THE EFFICIENCY OF CHEMOTHERAPY |
| title_short | SPECIFIC FEATURE OF HORMONAL PROFILE IN PATIENTS WITH PRIMARY AND RECURRENT BREAST CANCER AND THEIR ROLE IN THE EFFICIENCY OF CHEMOTHERAPY |
| title_sort | specific feature of hormonal profile in patients with primary and recurrent breast cancer and their role in the efficiency of chemotherapy |
| topic | breast cancer recurrence hormonal profile chemotherapy |
| url | https://ojrs.abvpress.ru/ojrs/article/view/286 |
| work_keys_str_mv | AT mbkozlova specificfeatureofhormonalprofileinpatientswithprimaryandrecurrentbreastcancerandtheirroleintheefficiencyofchemotherapy AT emfrantziyantz specificfeatureofhormonalprofileinpatientswithprimaryandrecurrentbreastcancerandtheirroleintheefficiencyofchemotherapy AT ganerodo specificfeatureofhormonalprofileinpatientswithprimaryandrecurrentbreastcancerandtheirroleintheefficiencyofchemotherapy AT rnsalatov specificfeatureofhormonalprofileinpatientswithprimaryandrecurrentbreastcancerandtheirroleintheefficiencyofchemotherapy AT rgluganskaya specificfeatureofhormonalprofileinpatientswithprimaryandrecurrentbreastcancerandtheirroleintheefficiencyofchemotherapy AT ipsidorenko specificfeatureofhormonalprofileinpatientswithprimaryandrecurrentbreastcancerandtheirroleintheefficiencyofchemotherapy AT mvkashubina specificfeatureofhormonalprofileinpatientswithprimaryandrecurrentbreastcancerandtheirroleintheefficiencyofchemotherapy |