Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats
The angiotensin 1-7 (Ang 1-7), is abundantly produced in kidneys and antagonizes the function of angiotensin II through Mas receptor (MasR) or other unknown mechanisms. In the current study, the role of MasR and steroid hormone estrogen on renal blood flow response to Ang 1-7 administration was inve...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Research in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.jrps.ir/article.asp?issn=1735-5362;year=2016;volume=11;issue=1;spage=65;epage=72;aulast=Saberi |
| _version_ | 1818912435958972416 |
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| author | Shadan Saberi Aghdas Dehghani Mehdi Nematbakhsh |
| author_facet | Shadan Saberi Aghdas Dehghani Mehdi Nematbakhsh |
| author_sort | Shadan Saberi |
| collection | DOAJ |
| description | The angiotensin 1-7 (Ang 1-7), is abundantly produced in kidneys and antagonizes the function of angiotensin II through Mas receptor (MasR) or other unknown mechanisms. In the current study, the role of MasR and steroid hormone estrogen on renal blood flow response to Ang 1-7 administration was investigated in ovariectomized (OV) female rats. OV female Wistar-rats received estradiol (500 μg/kg/week) or vehicle for two weeks. In the day of the experiment, the animals were anesthetized, cannulated, and the responses including mean arterial pressure, renal blood flow (RBF), and renal vascular resistance at the constant level of renal perfusion pressure to graded infusion of Ang 1-7 at 0, 100 and 300 ng/kg/min were determined in OV and OV estradiol-treated (OVE) rats, treated with vehicle or MasR antagonist; A779. RBF response to Ang 1-7 infusion increased dose-dependently in vehicle (P dose <0.001) and A779-treated (P dose<0.01) animals. However, when MasR was blocked, the RBF response to Ang 1-7 significantly increased in OV animals compared with OVE rats (P<0.05). When estradiol was limited by ovariectomy, A779 increased RBF response to Ang 1-7 administration, while this response was attenuated in OVE animals. |
| first_indexed | 2024-12-19T23:14:33Z |
| format | Article |
| id | doaj.art-1ba886a7a02347f7a50a6a42098df579 |
| institution | Directory Open Access Journal |
| issn | 1735-5362 1735-9414 |
| language | English |
| last_indexed | 2024-12-19T23:14:33Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Research in Pharmaceutical Sciences |
| spelling | doaj.art-1ba886a7a02347f7a50a6a42098df5792022-12-21T20:02:07ZengWolters Kluwer Medknow PublicationsResearch in Pharmaceutical Sciences1735-53621735-94142016-01-011116572Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated ratsShadan SaberiAghdas DehghaniMehdi NematbakhshThe angiotensin 1-7 (Ang 1-7), is abundantly produced in kidneys and antagonizes the function of angiotensin II through Mas receptor (MasR) or other unknown mechanisms. In the current study, the role of MasR and steroid hormone estrogen on renal blood flow response to Ang 1-7 administration was investigated in ovariectomized (OV) female rats. OV female Wistar-rats received estradiol (500 μg/kg/week) or vehicle for two weeks. In the day of the experiment, the animals were anesthetized, cannulated, and the responses including mean arterial pressure, renal blood flow (RBF), and renal vascular resistance at the constant level of renal perfusion pressure to graded infusion of Ang 1-7 at 0, 100 and 300 ng/kg/min were determined in OV and OV estradiol-treated (OVE) rats, treated with vehicle or MasR antagonist; A779. RBF response to Ang 1-7 infusion increased dose-dependently in vehicle (P dose <0.001) and A779-treated (P dose<0.01) animals. However, when MasR was blocked, the RBF response to Ang 1-7 significantly increased in OV animals compared with OVE rats (P<0.05). When estradiol was limited by ovariectomy, A779 increased RBF response to Ang 1-7 administration, while this response was attenuated in OVE animals.http://www.jrps.ir/article.asp?issn=1735-5362;year=2016;volume=11;issue=1;spage=65;epage=72;aulast=SaberiEstradiol; Renal blood flow; Angiotensin 1-7; MasR |
| spellingShingle | Shadan Saberi Aghdas Dehghani Mehdi Nematbakhsh Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats Research in Pharmaceutical Sciences Estradiol; Renal blood flow; Angiotensin 1-7; MasR |
| title | Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats |
| title_full | Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats |
| title_fullStr | Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats |
| title_full_unstemmed | Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats |
| title_short | Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats |
| title_sort | role of mas receptor in renal blood flow response to angiotensin 1 7 in ovariectomized estradiol treated rats |
| topic | Estradiol; Renal blood flow; Angiotensin 1-7; MasR |
| url | http://www.jrps.ir/article.asp?issn=1735-5362;year=2016;volume=11;issue=1;spage=65;epage=72;aulast=Saberi |
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