Emerging Roles of Platelets in Allergic Asthma
Allergic asthma is a complex chronic inflammatory disease of the airways, driven by Th2 immune responses and characterized by eosinophilic pulmonary inflammation, airway hyperresponsiveness, excessive mucus production, and airway remodeling. Overwhelming evidence from studies in animal models and al...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.846055/full |
| _version_ | 1818754513299832832 |
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| author | Ming Yue Mengjiao Hu Fangda Fu Hongfeng Ruan Chengliang Wu |
| author_facet | Ming Yue Mengjiao Hu Fangda Fu Hongfeng Ruan Chengliang Wu |
| author_sort | Ming Yue |
| collection | DOAJ |
| description | Allergic asthma is a complex chronic inflammatory disease of the airways, driven by Th2 immune responses and characterized by eosinophilic pulmonary inflammation, airway hyperresponsiveness, excessive mucus production, and airway remodeling. Overwhelming evidence from studies in animal models and allergic asthmatic patients suggests that platelets are aberrantly activated and recruited to the lungs. It has been established that platelets can interact with other immune cells and secrete various biochemical mediators to promote allergic sensitization and airway inflammatory response, and platelet deficiency may alleviate the pathological features and symptoms of allergic asthma. However, the comprehensive roles of platelets in allergic asthma have not been fully clarified, leaving attempts to treat allergic asthma with antiplatelet agents questionable. In this review, we summarize the role of platelet activation and pulmonary accumulation in allergic asthma; emphasis is placed on the different interactions between platelets with crucial immune cell types and the contribution of platelet-derived mediators in this context. Furthermore, clinical antiplatelet approaches to treat allergic asthma are discussed. This review provides a clearer understanding of the roles of platelets in the pathogenesis of allergic asthma and could be informative in the development of novel strategies for the treatment of allergic asthma. |
| first_indexed | 2024-12-18T05:24:27Z |
| format | Article |
| id | doaj.art-1bac50f8e3fe40deb5e3abbcc9079f48 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-18T05:24:27Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1bac50f8e3fe40deb5e3abbcc9079f482022-12-21T21:19:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-04-011310.3389/fimmu.2022.846055846055Emerging Roles of Platelets in Allergic AsthmaMing Yue0Mengjiao Hu1Fangda Fu2Hongfeng Ruan3Chengliang Wu4Department of Physiology, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Immunology and Microbiology, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, ChinaInstitute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaInstitute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaInstitute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaAllergic asthma is a complex chronic inflammatory disease of the airways, driven by Th2 immune responses and characterized by eosinophilic pulmonary inflammation, airway hyperresponsiveness, excessive mucus production, and airway remodeling. Overwhelming evidence from studies in animal models and allergic asthmatic patients suggests that platelets are aberrantly activated and recruited to the lungs. It has been established that platelets can interact with other immune cells and secrete various biochemical mediators to promote allergic sensitization and airway inflammatory response, and platelet deficiency may alleviate the pathological features and symptoms of allergic asthma. However, the comprehensive roles of platelets in allergic asthma have not been fully clarified, leaving attempts to treat allergic asthma with antiplatelet agents questionable. In this review, we summarize the role of platelet activation and pulmonary accumulation in allergic asthma; emphasis is placed on the different interactions between platelets with crucial immune cell types and the contribution of platelet-derived mediators in this context. Furthermore, clinical antiplatelet approaches to treat allergic asthma are discussed. This review provides a clearer understanding of the roles of platelets in the pathogenesis of allergic asthma and could be informative in the development of novel strategies for the treatment of allergic asthma.https://www.frontiersin.org/articles/10.3389/fimmu.2022.846055/fullplateletsallergic asthmadendritic cellseosinophilsplatelet-derived mediatorsantiplatelet strategies |
| spellingShingle | Ming Yue Mengjiao Hu Fangda Fu Hongfeng Ruan Chengliang Wu Emerging Roles of Platelets in Allergic Asthma Frontiers in Immunology platelets allergic asthma dendritic cells eosinophils platelet-derived mediators antiplatelet strategies |
| title | Emerging Roles of Platelets in Allergic Asthma |
| title_full | Emerging Roles of Platelets in Allergic Asthma |
| title_fullStr | Emerging Roles of Platelets in Allergic Asthma |
| title_full_unstemmed | Emerging Roles of Platelets in Allergic Asthma |
| title_short | Emerging Roles of Platelets in Allergic Asthma |
| title_sort | emerging roles of platelets in allergic asthma |
| topic | platelets allergic asthma dendritic cells eosinophils platelet-derived mediators antiplatelet strategies |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.846055/full |
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