Cu(II) AND Zn(II) COMPLEX COMPOUNDS WITH BIGUANIDES AROMATIC DERIVATIVES. SYNTHESIS, CHARACTERIZATION, BIOLOGICAL ACTIVITY
In this paper we report the synthesis, physical-chemical characterization and antimicrobial activity of some new complex compounds of hetero-aromatic biguanides ligands, chlorhexidine base (CHX) and chlorhexidine diacetate (CHXac2) with metallic ions Cu(II) and Zn(II), in different molar ratio. The...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Alma Mater Publishing House "Vasile Alecsandri" University of Bacau
2011-05-01
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| Series: | Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry |
| Subjects: | |
| Online Access: | http://pubs.ub.ro/dwnl.php?id=CSCC6201112V02S01A0004 |
| _version_ | 1831673565204709376 |
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| author | Ticuţa Negreanu-Pîrjol Bogdan Negreanu-Pîrjol Mirela Călinescu Florina Dumitru Rodica Sîrbu Ramona Stoicescu Ghassoub Rima Cornelia Guran |
| author_facet | Ticuţa Negreanu-Pîrjol Bogdan Negreanu-Pîrjol Mirela Călinescu Florina Dumitru Rodica Sîrbu Ramona Stoicescu Ghassoub Rima Cornelia Guran |
| author_sort | Ticuţa Negreanu-Pîrjol |
| collection | DOAJ |
| description | In this paper we report the synthesis, physical-chemical characterization and antimicrobial activity of some new complex compounds of hetero-aromatic biguanides ligands, chlorhexidine base (CHX) and chlorhexidine diacetate (CHXac2) with metallic ions Cu(II) and Zn(II), in different molar ratio. The synthesized complexes were characterized by elemental chemical analysis and differential thermal analysis. The stereochemistry of the metallic ions was determined by infrared spectra, UV-Vis, EPR spectroscopy and magnetic susceptibility in the aim to establish the complexes structures. The biological activity of the new complex compounds was identified in solid technique by measuring minimum inhibition diameter of bacterial and fungal culture, against three standard pathogen strains, Escherichia coli ATCC 25922, Staphilococcus aureus ATCC 25923 and Candida albicans ATCC 10231. The results show an increased specific antimicrobial activity for the complexes chlorhexidine:Cu(II) 1:1 and 1:2 compared with the one of the Zn(II) complexes. |
| first_indexed | 2024-12-20T03:30:02Z |
| format | Article |
| id | doaj.art-1bae934d3f2841eebf49e26c7e679d07 |
| institution | Directory Open Access Journal |
| issn | 1582-540X |
| language | English |
| last_indexed | 2024-12-20T03:30:02Z |
| publishDate | 2011-05-01 |
| publisher | Alma Mater Publishing House "Vasile Alecsandri" University of Bacau |
| record_format | Article |
| series | Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry |
| spelling | doaj.art-1bae934d3f2841eebf49e26c7e679d072022-12-21T19:55:01ZengAlma Mater Publishing House "Vasile Alecsandri" University of BacauScientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry1582-540X2011-05-01122127140Cu(II) AND Zn(II) COMPLEX COMPOUNDS WITH BIGUANIDES AROMATIC DERIVATIVES. SYNTHESIS, CHARACTERIZATION, BIOLOGICAL ACTIVITYTicuţa Negreanu-PîrjolBogdan Negreanu-PîrjolMirela CălinescuFlorina DumitruRodica SîrbuRamona StoicescuGhassoub RimaCornelia GuranIn this paper we report the synthesis, physical-chemical characterization and antimicrobial activity of some new complex compounds of hetero-aromatic biguanides ligands, chlorhexidine base (CHX) and chlorhexidine diacetate (CHXac2) with metallic ions Cu(II) and Zn(II), in different molar ratio. The synthesized complexes were characterized by elemental chemical analysis and differential thermal analysis. The stereochemistry of the metallic ions was determined by infrared spectra, UV-Vis, EPR spectroscopy and magnetic susceptibility in the aim to establish the complexes structures. The biological activity of the new complex compounds was identified in solid technique by measuring minimum inhibition diameter of bacterial and fungal culture, against three standard pathogen strains, Escherichia coli ATCC 25922, Staphilococcus aureus ATCC 25923 and Candida albicans ATCC 10231. The results show an increased specific antimicrobial activity for the complexes chlorhexidine:Cu(II) 1:1 and 1:2 compared with the one of the Zn(II) complexes.http://pubs.ub.ro/dwnl.php?id=CSCC6201112V02S01A0004biguanides derivativesbiological activitycomplex compoundscopper(II)zinc(II) |
| spellingShingle | Ticuţa Negreanu-Pîrjol Bogdan Negreanu-Pîrjol Mirela Călinescu Florina Dumitru Rodica Sîrbu Ramona Stoicescu Ghassoub Rima Cornelia Guran Cu(II) AND Zn(II) COMPLEX COMPOUNDS WITH BIGUANIDES AROMATIC DERIVATIVES. SYNTHESIS, CHARACTERIZATION, BIOLOGICAL ACTIVITY Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry biguanides derivatives biological activity complex compounds copper(II) zinc(II) |
| title | Cu(II) AND Zn(II) COMPLEX COMPOUNDS WITH BIGUANIDES AROMATIC DERIVATIVES. SYNTHESIS, CHARACTERIZATION, BIOLOGICAL ACTIVITY |
| title_full | Cu(II) AND Zn(II) COMPLEX COMPOUNDS WITH BIGUANIDES AROMATIC DERIVATIVES. SYNTHESIS, CHARACTERIZATION, BIOLOGICAL ACTIVITY |
| title_fullStr | Cu(II) AND Zn(II) COMPLEX COMPOUNDS WITH BIGUANIDES AROMATIC DERIVATIVES. SYNTHESIS, CHARACTERIZATION, BIOLOGICAL ACTIVITY |
| title_full_unstemmed | Cu(II) AND Zn(II) COMPLEX COMPOUNDS WITH BIGUANIDES AROMATIC DERIVATIVES. SYNTHESIS, CHARACTERIZATION, BIOLOGICAL ACTIVITY |
| title_short | Cu(II) AND Zn(II) COMPLEX COMPOUNDS WITH BIGUANIDES AROMATIC DERIVATIVES. SYNTHESIS, CHARACTERIZATION, BIOLOGICAL ACTIVITY |
| title_sort | cu ii and zn ii complex compounds with biguanides aromatic derivatives synthesis characterization biological activity |
| topic | biguanides derivatives biological activity complex compounds copper(II) zinc(II) |
| url | http://pubs.ub.ro/dwnl.php?id=CSCC6201112V02S01A0004 |
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