SOX2 and SOX2-MYC Reprogramming Process of Fibroblasts to the Neural Stem Cells Compromised by Senescence.

SOX2 and SOX2-MYC Reprogramming Process of Fibroblasts to the Neural Stem Cells Compromised by Senescence.

Tumorigenic potential of induced pluripotent stem cells (iPSCs) infiltrating population of induced neural stem cells (iNSCs) generated from iPSCs may limit their medical applications. To overcome such a difficulty, direct reprogramming of adult somatic cells into iNSCs was proposed. The aim of this...

Full description

Bibliographic Details
Main Authors:	Marta Winiecka-Klimek, Maciej Smolarz, Maciej P Walczak, Jolanta Zieba, Krystyna Hulas-Bigoszewska, Blazej Kmieciak, Sylwester Piaskowski, Piotr Rieske, Dawid P Grzela, Ewelina Stoczynska-Fidelus
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4633175?pdf=render

Similar Items

IDH1R132H in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis.
by: Kamila Rosiak, et al.
Published: (2016-01-01)

The failure in the stabilization of glioblastoma-derived cell lines: spontaneous in vitro senescence as the main culprit.
by: Ewelina Stoczynska-Fidelus, et al.
Published: (2014-01-01)

Successful elimination of non-neural cells and unachievable elimination of glial cells by means of commonly used cell culture manipulations during differentiation of GFAP and SOX2 positive neural progenitors (NHA) to neuronal cells
by: Krynska Barbara, et al.
Published: (2008-07-01)

Limited importance of the dominant-negative effect of <it>TP53 </it>missense mutations
by: Kordek Radzislaw, et al.
Published: (2011-06-01)

EGFR Activation Leads to Cell Death Independent of PI3K/AKT/mTOR in an AD293 Cell Line.
by: Cezary Treda, et al.
Published: (2016-01-01)

Elevating SOX2 Downregulates MYC through a SOX2:MYC Signaling Axis and Induces a Slowly Cycling Proliferative State in Human Tumor Cells
by: Ethan P. Metz, et al.
Published: (2022-04-01)

The Role of SOX2 and SOX9 in Radioresistance and Tumor Recurrence
by: Silvia Barbosa, et al.
Published: (2024-01-01)

SOX2 and SOX21 in Lung Epithelial Differentiation and Repair
by: Evelien Eenjes, et al.
Published: (2022-10-01)

Sox enters the picture
by: Felix Kaufholz, et al.
Published: (2018-10-01)

SOX6 AU controls myogenesis by cis-modulation of SOX6 in cattle
by: Xin Li, et al.
Published: (2024-12-01)

Characterization of Schistosome Sox Genes and Identification of a Flatworm Class of Sox Regulators
by: Stephanie Wood, et al.
Published: (2023-05-01)

sox4 and sox11 function during Xenopus laevis eye development.
by: Wiebke Cizelsky, et al.
Published: (2013-01-01)

Sox9a, not sox9b is required for normal cartilage development in zebrafish
by: Qiaohong Lin, et al.
Published: (2021-05-01)

SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways
by: Evelien Eenjes, et al.
Published: (2021-07-01)

The proposed SOx and particulate standard/
by: Specialty Conference on the Proposed SOx and Particulate Standard (1980 : Atlanta, Georgia), et al.
Published: (1981)

Taking aim at Sox18
by: Injune Kim, et al.
Published: (2017-01-01)

Evolution of the insect <it>Sox </it>genes
by: Dearden Peter K, et al.
Published: (2008-04-01)

Regeneration difficulties in patients with FQAD can limit the use of iPSc-based cell therapy
by: Dagmara Grot, et al.
Published: (2022-05-01)

SOX2-Sensing: Insights into the Role of SOX2 in the Generation of Sensory Cell Types in Vertebrates
by: Sara Mercurio
Published: (2023-04-01)

Expression profile of sox5 and sox6 in sertoli and spermatogonial cells in growing mice testis
by: Zia Ur REHMAN, et al.
Published: (2019-10-01)

Sorting Sox: Diverse Roles for Sox Transcription Factors During Neural Crest and Craniofacial Development
by: Elizabeth N. Schock, et al.
Published: (2020-12-01)

Sox2 uses multiple domains to associate with proteins present in Sox2-protein complexes.
by: Jesse L Cox, et al.
Published: (2010-11-01)

Multi-Omics Analysis of <i>SOX4</i>, <i>SOX11</i>, and <i>SOX12</i> Expression and the Associated Pathways in Human Cancers
by: Jaekwon Seok, et al.
Published: (2021-08-01)

Arrested neural and advanced mesenchymal differentiation of glioblastoma cells-comparative study with neural progenitors
by: Biernat Wojciech, et al.
Published: (2009-02-01)

Intermediates in the Sox sulfur oxidation pathway are bound to a sulfane conjugate of the carrier protein SoxYZ
by: Grabarczyk, D, et al.
Published: (2017)

SOX2 and SOX9 Expression in Developing Postnatal Opossum (<i>Monodelphis domestica</i>) Cortex
by: Zrinko Baričević, et al.
Published: (2024-01-01)

Cloning and Expression of Sox2 and Sox9 in Embryonic and Gonadal Development of <i>Lutraria sieboldii</i>
by: Min Lu, et al.
Published: (2022-12-01)

SOX11, SOX10 and MITF Gene Interaction: A Possible Diagnostic Tool in Malignant Melanoma
by: Marius-Alexandru Beleaua, et al.
Published: (2021-03-01)

Characterization of DNA binding and oligomerization domains of stem cell transcription factor Sox9 and Sox5
by: Saravanan Vivekanandan
Published: (2013)

Repressing of SOX6 and SOX9 in Situ Chondrogenic Differentiation of Rat Bone Marrow Stromal Cells
by: Mohammad Hassan Karimfar, et al.
Published: (2015-05-01)

Analyses of Sox-B and Sox-E Family Genes in the Cephalopod Sepia officinalis: Revealing the Conserved and the Unusual.
by: Laura Focareta, et al.
Published: (2016-01-01)

Exportin 4 interacts with Sox9 through the HMG Box and inhibits the DNA binding of Sox9.
by: Megumi Tsuchiya, et al.
Published: (2011-01-01)

Intermediates in the Sox sulfur oxidation pathway are bound to a sulfane conjugate of the carrier protein SoxYZ.
by: Daniel B Grabarczyk, et al.
Published: (2017-01-01)

Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma.
by: Olga Shakhova, et al.
Published: (2015-01-01)

Increased EGFRvIII Epitope Accessibility after Tyrosine Kinase Inhibitor Treatment of Glioblastoma Cells Creates More Opportunities for Immunotherapy
by: Cezary Tręda, et al.
Published: (2023-02-01)

C-MYC Transcriptionally Amplifies SOX2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells
by: Kelvin Y. Kwan, et al.
Published: (2015-01-01)

Editorial: a model, MIA and Sox.
by: Goding, C
Published: (2005)

SoxB, cell cycle and neurogenesis
by: Theodoros eKarnavas, et al.
Published: (2013-10-01)

Specificity and application of SOX2 antibody
by: Longqin Wei, et al.
Published: (2020-05-01)

Oestrogen shuts the door on SOX9
by: Mork Lindsey, et al.
Published: (2010-08-01)