Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional study
Abstract Background The aim of the study was to investigate the association of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios (PLR) with standard inflammation parameters, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), complement component C3, anti-doub...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-11-01
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| Series: | Egyptian Rheumatology and Rehabilitation |
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| Online Access: | https://doi.org/10.1186/s43166-023-00222-9 |
| _version_ | 1797630151724367872 |
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| author | Valentina Živković Tatjana Cvetković Biljana Radovanović Dinić Vladimir Jurišić |
| author_facet | Valentina Živković Tatjana Cvetković Biljana Radovanović Dinić Vladimir Jurišić |
| author_sort | Valentina Živković |
| collection | DOAJ |
| description | Abstract Background The aim of the study was to investigate the association of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios (PLR) with standard inflammation parameters, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), complement component C3, anti-double-stranded deoxyribonucleic acid (anti-dsDNA), anti-nucleosome and anti-C1q antibodies, and serum and urinary monocyte-chemoattractant protein-1 (MCP-1) with disease activity in patients with systemic lupus erythematosus (SLE). Results This study included 160 patients (145 female and 15 male patients), hospitalized at the Rheumatology Department. A positive correlation between NLR and ESR (p < 0.01), anti-dsDNA antibodies (p < 0.05), and PLR (p < 0.001) was obtained, with a negative correlation with C3 (p < 0.005). PLR shows a positive correlation with ESR (p < 0.001), CRP (p < 0.005), anti-dsDNA antibodies (p < 0.001), anti-nucleosome antibodies (p < 0.05), and urine MCP-1 (p < 0.05), with a negative correlation with C3 (p < 0.005). Univariate analysis showed that all the examined laboratory parameters were independent predictors of disease activity (p < 0.001), while the method of standard multiple regression analysis revealed the most significant ESR and serum MCP-1 (p < 0.05). Conclusions NLR and PLR, as inexpensive and accessible biomarkers, can help in routine clinical practice for the estimation of disease activity in SLE patients. |
| first_indexed | 2024-03-11T11:04:05Z |
| format | Article |
| id | doaj.art-1bb42803688e41e8ad27f437e77d21e4 |
| institution | Directory Open Access Journal |
| issn | 2090-3235 |
| language | English |
| last_indexed | 2024-03-11T11:04:05Z |
| publishDate | 2023-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Rheumatology and Rehabilitation |
| spelling | doaj.art-1bb42803688e41e8ad27f437e77d21e42023-11-12T12:19:56ZengSpringerOpenEgyptian Rheumatology and Rehabilitation2090-32352023-11-015011810.1186/s43166-023-00222-9Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional studyValentina Živković0Tatjana Cvetković1Biljana Radovanović Dinić2Vladimir Jurišić3Faculty of Medicine, University of NišFaculty of Medicine, University of NišFaculty of Medicine, University of NišFaculty of Medical Sciences, University of KragujevacAbstract Background The aim of the study was to investigate the association of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios (PLR) with standard inflammation parameters, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), complement component C3, anti-double-stranded deoxyribonucleic acid (anti-dsDNA), anti-nucleosome and anti-C1q antibodies, and serum and urinary monocyte-chemoattractant protein-1 (MCP-1) with disease activity in patients with systemic lupus erythematosus (SLE). Results This study included 160 patients (145 female and 15 male patients), hospitalized at the Rheumatology Department. A positive correlation between NLR and ESR (p < 0.01), anti-dsDNA antibodies (p < 0.05), and PLR (p < 0.001) was obtained, with a negative correlation with C3 (p < 0.005). PLR shows a positive correlation with ESR (p < 0.001), CRP (p < 0.005), anti-dsDNA antibodies (p < 0.001), anti-nucleosome antibodies (p < 0.05), and urine MCP-1 (p < 0.05), with a negative correlation with C3 (p < 0.005). Univariate analysis showed that all the examined laboratory parameters were independent predictors of disease activity (p < 0.001), while the method of standard multiple regression analysis revealed the most significant ESR and serum MCP-1 (p < 0.05). Conclusions NLR and PLR, as inexpensive and accessible biomarkers, can help in routine clinical practice for the estimation of disease activity in SLE patients.https://doi.org/10.1186/s43166-023-00222-9BiomarkersDisease activityNeutrophilsPlateletsSistemic lupus erythematosus |
| spellingShingle | Valentina Živković Tatjana Cvetković Biljana Radovanović Dinić Vladimir Jurišić Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional study Egyptian Rheumatology and Rehabilitation Biomarkers Disease activity Neutrophils Platelets Sistemic lupus erythematosus |
| title | Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional study |
| title_full | Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional study |
| title_fullStr | Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional study |
| title_full_unstemmed | Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional study |
| title_short | Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional study |
| title_sort | correlation of hematological parameters antibodies and cytokines with disease activity in systemic lupus erythematosus a cross sectional study |
| topic | Biomarkers Disease activity Neutrophils Platelets Sistemic lupus erythematosus |
| url | https://doi.org/10.1186/s43166-023-00222-9 |
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