When aging reaches CD4+ T-cells: phenotypic and functional changes
Beyond midlife, the immune system shows aging features and its defensive capability becomes impaired, by a process known as immunosenescence that involves many changes in the innate and adaptive responses. Innate immunity seems to be better preserved globally, while the adaptive immune response exhi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00107/full |
| _version_ | 1819231636285292544 |
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| author | Marco Antonio Moro-García Rebeca eAlonso-Arias Carlos eLopez-Larrea Carlos eLopez-Larrea |
| author_facet | Marco Antonio Moro-García Rebeca eAlonso-Arias Carlos eLopez-Larrea Carlos eLopez-Larrea |
| author_sort | Marco Antonio Moro-García |
| collection | DOAJ |
| description | Beyond midlife, the immune system shows aging features and its defensive capability becomes impaired, by a process known as immunosenescence that involves many changes in the innate and adaptive responses. Innate immunity seems to be better preserved globally, while the adaptive immune response exhibits profound age-dependent modifications. Elderly people display a decline in numbers of naïve T-cells in peripheral blood and lymphoid tissues, while, in contrast, their proportion of highly differentiated effector and memory T-cells, such as the CD28null T-cells, increases markedly. Naïve and memory CD4+ T-cells constitute a highly dynamic system with constant homeostatic and antigen-driven proliferation, influx, and loss of T-cells. Thymic activity dwindles with age and essentially ceases in the later decades of life, severely constraining the generation of new T-cells. Homeostatic control mechanisms are very effective at maintaining a large and diverse subset of naïve CD4+ T-cells throughout life, but although later than in CD8+T-cell compartment, these mechanisms ultimately fail with age. |
| first_indexed | 2024-12-23T11:48:07Z |
| format | Article |
| id | doaj.art-1bb6b1e8f050400e9808e779985411fd |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T11:48:07Z |
| publishDate | 2013-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1bb6b1e8f050400e9808e779985411fd2022-12-21T17:48:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-05-01410.3389/fimmu.2013.0010748201When aging reaches CD4+ T-cells: phenotypic and functional changesMarco Antonio Moro-García0Rebeca eAlonso-Arias1Carlos eLopez-Larrea2Carlos eLopez-Larrea3Hospital Universitario Central de AsturiasHospital Universitario Central de AsturiasHospital Universitario Central de AsturiasFundación Renal “Iñigo Alvarez de ToledoBeyond midlife, the immune system shows aging features and its defensive capability becomes impaired, by a process known as immunosenescence that involves many changes in the innate and adaptive responses. Innate immunity seems to be better preserved globally, while the adaptive immune response exhibits profound age-dependent modifications. Elderly people display a decline in numbers of naïve T-cells in peripheral blood and lymphoid tissues, while, in contrast, their proportion of highly differentiated effector and memory T-cells, such as the CD28null T-cells, increases markedly. Naïve and memory CD4+ T-cells constitute a highly dynamic system with constant homeostatic and antigen-driven proliferation, influx, and loss of T-cells. Thymic activity dwindles with age and essentially ceases in the later decades of life, severely constraining the generation of new T-cells. Homeostatic control mechanisms are very effective at maintaining a large and diverse subset of naïve CD4+ T-cells throughout life, but although later than in CD8+T-cell compartment, these mechanisms ultimately fail with age.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00107/fullInflammationimmunosenescenceT-cellsIL-15CMVNKRs |
| spellingShingle | Marco Antonio Moro-García Rebeca eAlonso-Arias Carlos eLopez-Larrea Carlos eLopez-Larrea When aging reaches CD4+ T-cells: phenotypic and functional changes Frontiers in Immunology Inflammation immunosenescence T-cells IL-15 CMV NKRs |
| title | When aging reaches CD4+ T-cells: phenotypic and functional changes |
| title_full | When aging reaches CD4+ T-cells: phenotypic and functional changes |
| title_fullStr | When aging reaches CD4+ T-cells: phenotypic and functional changes |
| title_full_unstemmed | When aging reaches CD4+ T-cells: phenotypic and functional changes |
| title_short | When aging reaches CD4+ T-cells: phenotypic and functional changes |
| title_sort | when aging reaches cd4 t cells phenotypic and functional changes |
| topic | Inflammation immunosenescence T-cells IL-15 CMV NKRs |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00107/full |
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