miR-223: a key regulator of pulmonary inflammation
Small noncoding RNAs, known as microRNAs (miRNAs), are vital for the regulation of diverse biological processes. miR-223, an evolutionarily conserved anti-inflammatory miRNA expressed in cells of the myeloid lineage, has been implicated in the regulation of monocyte–macrophage differentiation, proin...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1187557/full |
| _version_ | 1797789193231925248 |
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| author | Mingyu Shi Qianying Lu Yanmei Zhao Ziling Ding Sifan Yu Junfeng Li Mengjun Ji Haojun Fan Haojun Fan Shike Hou Shike Hou |
| author_facet | Mingyu Shi Qianying Lu Yanmei Zhao Ziling Ding Sifan Yu Junfeng Li Mengjun Ji Haojun Fan Haojun Fan Shike Hou Shike Hou |
| author_sort | Mingyu Shi |
| collection | DOAJ |
| description | Small noncoding RNAs, known as microRNAs (miRNAs), are vital for the regulation of diverse biological processes. miR-223, an evolutionarily conserved anti-inflammatory miRNA expressed in cells of the myeloid lineage, has been implicated in the regulation of monocyte–macrophage differentiation, proinflammatory responses, and the recruitment of neutrophils. The biological functions of this gene are regulated by its expression levels in cells or tissues. In this review, we first outline the regulatory role of miR-223 in granulocytes, macrophages, endothelial cells, epithelial cells and dendritic cells (DCs). Then, we summarize the possible role of miR-223 in chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), coronavirus disease 2019 (COVID-19) and other pulmonary inflammatory diseases to better understand the molecular regulatory networks in pulmonary inflammatory diseases. |
| first_indexed | 2024-03-13T01:46:18Z |
| format | Article |
| id | doaj.art-1bb701ec316b41c899bbf0471919698c |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T01:46:18Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-1bb701ec316b41c899bbf0471919698c2023-07-03T06:43:00ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-07-011010.3389/fmed.2023.11875571187557miR-223: a key regulator of pulmonary inflammationMingyu Shi0Qianying Lu1Yanmei Zhao2Ziling Ding3Sifan Yu4Junfeng Li5Mengjun Ji6Haojun Fan7Haojun Fan8Shike Hou9Shike Hou10Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaWenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, ChinaInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, ChinaWenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, ChinaSmall noncoding RNAs, known as microRNAs (miRNAs), are vital for the regulation of diverse biological processes. miR-223, an evolutionarily conserved anti-inflammatory miRNA expressed in cells of the myeloid lineage, has been implicated in the regulation of monocyte–macrophage differentiation, proinflammatory responses, and the recruitment of neutrophils. The biological functions of this gene are regulated by its expression levels in cells or tissues. In this review, we first outline the regulatory role of miR-223 in granulocytes, macrophages, endothelial cells, epithelial cells and dendritic cells (DCs). Then, we summarize the possible role of miR-223 in chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), coronavirus disease 2019 (COVID-19) and other pulmonary inflammatory diseases to better understand the molecular regulatory networks in pulmonary inflammatory diseases.https://www.frontiersin.org/articles/10.3389/fmed.2023.1187557/fullmiR-223inflammatory diseaseacute lung injury (ALI)asthmachronic obstructive pulmonary disease (COPD)COVID-19 |
| spellingShingle | Mingyu Shi Qianying Lu Yanmei Zhao Ziling Ding Sifan Yu Junfeng Li Mengjun Ji Haojun Fan Haojun Fan Shike Hou Shike Hou miR-223: a key regulator of pulmonary inflammation Frontiers in Medicine miR-223 inflammatory disease acute lung injury (ALI) asthma chronic obstructive pulmonary disease (COPD) COVID-19 |
| title | miR-223: a key regulator of pulmonary inflammation |
| title_full | miR-223: a key regulator of pulmonary inflammation |
| title_fullStr | miR-223: a key regulator of pulmonary inflammation |
| title_full_unstemmed | miR-223: a key regulator of pulmonary inflammation |
| title_short | miR-223: a key regulator of pulmonary inflammation |
| title_sort | mir 223 a key regulator of pulmonary inflammation |
| topic | miR-223 inflammatory disease acute lung injury (ALI) asthma chronic obstructive pulmonary disease (COPD) COVID-19 |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1187557/full |
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