Adenovirus-mediated Gene Therapy for Allergy
Allergy poses a heavy health burden in modern society. Other than symptom-relieving medications, the only available treatment approach is allergen-specific immunotherapy, which in spite of offering a potential cure, requires a long treatment duration with multiple doses of allergen administration an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2018-12-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1685 |
| _version_ | 1811280519548108800 |
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| author | Shikun Ma Jian Guan |
| author_facet | Shikun Ma Jian Guan |
| author_sort | Shikun Ma |
| collection | DOAJ |
| description | Allergy poses a heavy health burden in modern society. Other than symptom-relieving medications, the only available treatment approach is allergen-specific immunotherapy, which in spite of offering a potential cure, requires a long treatment duration with multiple doses of allergen administration and carries a risk of anaphylaxis. Gene therapy has shown advantages in experimental studies for treatment of tumors, genetic diseases, chronic infections, and allergy. To date, adenovirus has been the most extensively used gene transfer vector, and offers high efficiency and safety. Here, we review studies of adenovirus-mediated gene therapy targeting different steps in the development of allergic diseases. Adenovirus-mediated gene therapy might be a promising add-on therapy for allergy treatment. |
| first_indexed | 2024-04-13T01:16:15Z |
| format | Article |
| id | doaj.art-1bb7b650d13e45efa074a86f93a46dec |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-04-13T01:16:15Z |
| publishDate | 2018-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-1bb7b650d13e45efa074a86f93a46dec2022-12-22T03:08:55ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492018-12-0117610.18502/ijaai.v17i6.6131685Adenovirus-mediated Gene Therapy for AllergyShikun Ma0Jian Guan1Department of Allergy, Peking Union Medical College Hospital, Chineses Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaAllergy poses a heavy health burden in modern society. Other than symptom-relieving medications, the only available treatment approach is allergen-specific immunotherapy, which in spite of offering a potential cure, requires a long treatment duration with multiple doses of allergen administration and carries a risk of anaphylaxis. Gene therapy has shown advantages in experimental studies for treatment of tumors, genetic diseases, chronic infections, and allergy. To date, adenovirus has been the most extensively used gene transfer vector, and offers high efficiency and safety. Here, we review studies of adenovirus-mediated gene therapy targeting different steps in the development of allergic diseases. Adenovirus-mediated gene therapy might be a promising add-on therapy for allergy treatment.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1685AdenovirusAllergyGene therapyImmunotherapyVaccine |
| spellingShingle | Shikun Ma Jian Guan Adenovirus-mediated Gene Therapy for Allergy Iranian Journal of Allergy, Asthma and Immunology Adenovirus Allergy Gene therapy Immunotherapy Vaccine |
| title | Adenovirus-mediated Gene Therapy for Allergy |
| title_full | Adenovirus-mediated Gene Therapy for Allergy |
| title_fullStr | Adenovirus-mediated Gene Therapy for Allergy |
| title_full_unstemmed | Adenovirus-mediated Gene Therapy for Allergy |
| title_short | Adenovirus-mediated Gene Therapy for Allergy |
| title_sort | adenovirus mediated gene therapy for allergy |
| topic | Adenovirus Allergy Gene therapy Immunotherapy Vaccine |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1685 |
| work_keys_str_mv | AT shikunma adenovirusmediatedgenetherapyforallergy AT jianguan adenovirusmediatedgenetherapyforallergy |