Laryngeal Cryptococcosis Associated With Inhaled Corticosteroid Use: Case Reports and Literature Review
Laryngeal cryptococcosis is a rare clinical entity. There have been a limited number of case reports in the literature with no consensus regarding optimal management. This review contributes two additional case reports of immunocompetent patients with cryptococcal infection of the larynx in whom exp...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fsurg.2017.00063/full |
| _version_ | 1811243436024528896 |
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| author | Daniel Jun Yi Wong Peter Stanley Paul Paddle Paul Paddle |
| author_facet | Daniel Jun Yi Wong Peter Stanley Paul Paddle Paul Paddle |
| author_sort | Daniel Jun Yi Wong |
| collection | DOAJ |
| description | Laryngeal cryptococcosis is a rare clinical entity. There have been a limited number of case reports in the literature with no consensus regarding optimal management. This review contributes two additional case reports of immunocompetent patients with cryptococcal infection of the larynx in whom exposure to high doses of inhaled corticosteroids is proposed as a significant risk factor. Twenty cases were identified from review of the literature. All patients presented with hoarseness and a spectrum of microlaryngoscopic features, often mimicking laryngeal malignancy. The majority of cases were treated with systemic antifungal therapy, three cases had surgical excision alone, and another three had a combination of medical and surgical management. Risk factor modification, in the form of a reduction in inhaled corticosteroid was employed in the two new cases, and in some previously published cases. Risk factor modification, such as reduction of inhaled corticosteroid dose, in addition to oral antifungal agents can be effective in managing cryptococcal laryngitis. |
| first_indexed | 2024-04-12T14:07:12Z |
| format | Article |
| id | doaj.art-1bb7f8b238904c7a8cf33d2ed2ac13e8 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-12T14:07:12Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-1bb7f8b238904c7a8cf33d2ed2ac13e82022-12-22T03:30:01ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2017-11-01410.3389/fsurg.2017.00063311847Laryngeal Cryptococcosis Associated With Inhaled Corticosteroid Use: Case Reports and Literature ReviewDaniel Jun Yi Wong0Peter Stanley1Paul Paddle2Paul Paddle3Department of Otolaryngology, Head and Neck Surgery, Monash Health, Melbourne, VIC, AustraliaDepartment of Infectious Diseases, St Vincent’s Hospital, Melbourne, VIC, AustraliaDepartment of Otolaryngology, Head and Neck Surgery, Monash Health, Melbourne, VIC, AustraliaDepartment of Surgery, Faculty Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, AustraliaLaryngeal cryptococcosis is a rare clinical entity. There have been a limited number of case reports in the literature with no consensus regarding optimal management. This review contributes two additional case reports of immunocompetent patients with cryptococcal infection of the larynx in whom exposure to high doses of inhaled corticosteroids is proposed as a significant risk factor. Twenty cases were identified from review of the literature. All patients presented with hoarseness and a spectrum of microlaryngoscopic features, often mimicking laryngeal malignancy. The majority of cases were treated with systemic antifungal therapy, three cases had surgical excision alone, and another three had a combination of medical and surgical management. Risk factor modification, in the form of a reduction in inhaled corticosteroid was employed in the two new cases, and in some previously published cases. Risk factor modification, such as reduction of inhaled corticosteroid dose, in addition to oral antifungal agents can be effective in managing cryptococcal laryngitis.http://journal.frontiersin.org/article/10.3389/fsurg.2017.00063/fullCryptococcuslarynxlaryngitisinfectionfluconazoleantifungal |
| spellingShingle | Daniel Jun Yi Wong Peter Stanley Paul Paddle Paul Paddle Laryngeal Cryptococcosis Associated With Inhaled Corticosteroid Use: Case Reports and Literature Review Frontiers in Surgery Cryptococcus larynx laryngitis infection fluconazole antifungal |
| title | Laryngeal Cryptococcosis Associated With Inhaled Corticosteroid Use: Case Reports and Literature Review |
| title_full | Laryngeal Cryptococcosis Associated With Inhaled Corticosteroid Use: Case Reports and Literature Review |
| title_fullStr | Laryngeal Cryptococcosis Associated With Inhaled Corticosteroid Use: Case Reports and Literature Review |
| title_full_unstemmed | Laryngeal Cryptococcosis Associated With Inhaled Corticosteroid Use: Case Reports and Literature Review |
| title_short | Laryngeal Cryptococcosis Associated With Inhaled Corticosteroid Use: Case Reports and Literature Review |
| title_sort | laryngeal cryptococcosis associated with inhaled corticosteroid use case reports and literature review |
| topic | Cryptococcus larynx laryngitis infection fluconazole antifungal |
| url | http://journal.frontiersin.org/article/10.3389/fsurg.2017.00063/full |
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