Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet
Hydrogen, as a medical gas, is a promising emerging treatment for many diseases related to inflammation and oxidative stress. Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets constitute an attractive formulation strategy for...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/12/1327 |
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| author | Moritz Rosch Kurt Lucas Jozef Al-Gousous Ulrich Pöschl Peter Langguth |
| author_facet | Moritz Rosch Kurt Lucas Jozef Al-Gousous Ulrich Pöschl Peter Langguth |
| author_sort | Moritz Rosch |
| collection | DOAJ |
| description | Hydrogen, as a medical gas, is a promising emerging treatment for many diseases related to inflammation and oxidative stress. Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets constitute an attractive formulation strategy for oral delivery. In this regard, saccharide-based excipients represent an important class of potential fillers with high water solubility and sweet taste. In this study, we investigated the effect of different saccharides on the morphological and mechanical properties and the disintegration of hydrogen-generating effervescent tablets prepared by dry granulation. Mannitol was found to be superior to other investigated saccharides and promoted far more rapid hydrogen generation combined with acceptable mechanical properties. In further product optimization involving investigation of lubricant effects, adipic acid was selected for the optimized tablet, due to regulatory considerations. |
| first_indexed | 2024-03-10T03:20:06Z |
| format | Article |
| id | doaj.art-1bb8ef83191e41bd810072b316132bc7 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T03:20:06Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-1bb8ef83191e41bd810072b316132bc72023-11-23T10:04:10ZengMDPI AGPharmaceuticals1424-82472021-12-011412132710.3390/ph14121327Formulation and Characterization of an Effervescent Hydrogen-Generating TabletMoritz Rosch0Kurt Lucas1Jozef Al-Gousous2Ulrich Pöschl3Peter Langguth4Multiphase Chemistry Department, Max Planck Institute for Chemistry, 55128 Mainz, GermanyMultiphase Chemistry Department, Max Planck Institute for Chemistry, 55128 Mainz, GermanyDepartment of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, 55128 Mainz, GermanyMultiphase Chemistry Department, Max Planck Institute for Chemistry, 55128 Mainz, GermanyDepartment of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, 55128 Mainz, GermanyHydrogen, as a medical gas, is a promising emerging treatment for many diseases related to inflammation and oxidative stress. Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets constitute an attractive formulation strategy for oral delivery. In this regard, saccharide-based excipients represent an important class of potential fillers with high water solubility and sweet taste. In this study, we investigated the effect of different saccharides on the morphological and mechanical properties and the disintegration of hydrogen-generating effervescent tablets prepared by dry granulation. Mannitol was found to be superior to other investigated saccharides and promoted far more rapid hydrogen generation combined with acceptable mechanical properties. In further product optimization involving investigation of lubricant effects, adipic acid was selected for the optimized tablet, due to regulatory considerations.https://www.mdpi.com/1424-8247/14/12/1327tablethydrogeneffervescentroller compactiondynamic vapor sorptionstability |
| spellingShingle | Moritz Rosch Kurt Lucas Jozef Al-Gousous Ulrich Pöschl Peter Langguth Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet Pharmaceuticals tablet hydrogen effervescent roller compaction dynamic vapor sorption stability |
| title | Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet |
| title_full | Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet |
| title_fullStr | Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet |
| title_full_unstemmed | Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet |
| title_short | Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet |
| title_sort | formulation and characterization of an effervescent hydrogen generating tablet |
| topic | tablet hydrogen effervescent roller compaction dynamic vapor sorption stability |
| url | https://www.mdpi.com/1424-8247/14/12/1327 |
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