Comparative quantitative survey of patient experience in Barrett’s oesophagus and other gastrointestinal disorders
Objective To assess health-related quality of life in patients with non-dysplastic Barrett’s oesophagus (NDBO) and endoscopically treated dysplastic Barrett’s oesophagus (DBO).Design This quantitative, self-administered questionnaire study was conducted across three National Health Service hospitals...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-12-01
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| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/7/1/e000357.full |
| _version_ | 1826933047941922816 |
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| author | John McLaughlin Yeng Ang James Britton Paraskevi Taxiarchi Glen Martin Robert Willert Maria Horne Shaheen Hamdy |
| author_facet | John McLaughlin Yeng Ang James Britton Paraskevi Taxiarchi Glen Martin Robert Willert Maria Horne Shaheen Hamdy |
| author_sort | John McLaughlin |
| collection | DOAJ |
| description | Objective To assess health-related quality of life in patients with non-dysplastic Barrett’s oesophagus (NDBO) and endoscopically treated dysplastic Barrett’s oesophagus (DBO).Design This quantitative, self-administered questionnaire study was conducted across three National Health Service hospitals. Data were collected from three other cohorts; gastro-oesophageal reflux disease (GORD), colonic polyp surveillance and healthy individuals. Fisher’s exact and Spearman’s rank correlation tests were used for analysis. Propensity score matching adjusted for age, sex and comorbidities.Results 687 participants were eligible for analysis (NDBO n=306, DBO n=49, GORD n=132, colonic polyps n=152 and healthy n=48). 53% of NDBO participants reported similarly high cancer worry, comparable to DBO (50%, p=0.933) and colonic polyp participants (51%, p=0.355). Less cancer worry was reported in GORD participants (43.4%, p=0.01 vs NDBO). NDBO participants reported anxiety in 15.8% and depression in 8.6% of cases, which was similar to the other disease cohorts. Moderate or severe heartburn or acid regurgitation was found in 11% and 10%, respectively, in the NDBO cohort, comparable to DBO participants (heartburn 2% p=0.172, acid regurgitation 4% p=0.31) but lower (better) than GORD participants (heartburn 31% p=<0.001, acid regurgitation 25% p=0.001). NDBO participants with moderate or severe GORD symptoms were associated with higher rates of anxiety (p=<0.001), depression (p=<0.001) and cancer worry (p=<0.001). NDBO patients appropriately perceiving their cancer risk as low had lower rates of cancer worry (p=<0.001).Conclusion This study provides insight into the problems Barrett’s oesophagus patients may face. Future care pathways must be more patient focussed to address misconceptions of cancer risk, oesophageal cancer related worry and GORD symptom control. |
| first_indexed | 2024-12-21T17:55:56Z |
| format | Article |
| id | doaj.art-1bba451eb5ae44fcb14463955ce460c5 |
| institution | Directory Open Access Journal |
| issn | 2054-4774 |
| language | English |
| last_indexed | 2025-02-17T17:25:33Z |
| publishDate | 2020-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj.art-1bba451eb5ae44fcb14463955ce460c52024-12-14T21:10:09ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742020-12-017110.1136/bmjgast-2019-000357Comparative quantitative survey of patient experience in Barrett’s oesophagus and other gastrointestinal disordersJohn McLaughlin0Yeng Ang1James Britton2Paraskevi Taxiarchi3Glen Martin4Robert Willert5Maria Horne6Shaheen Hamdy7Department of Gastroenterology, Northern Care Alliance NHS Foundation Trust, Salford, Manchester, UK1 Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UKGastroenterology, Wrightington, Wigan and Leigh NHS Foundation Trust, Wigan, UKDivision of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UKCentre for Health Informatics, The University of Manchester, Manchester, UKManchester University NHS Foundation Trust, Manchester, UK5 School of Healthcare, University of Leeds, Faculty of Medicine and Health, Leeds, UKDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UKObjective To assess health-related quality of life in patients with non-dysplastic Barrett’s oesophagus (NDBO) and endoscopically treated dysplastic Barrett’s oesophagus (DBO).Design This quantitative, self-administered questionnaire study was conducted across three National Health Service hospitals. Data were collected from three other cohorts; gastro-oesophageal reflux disease (GORD), colonic polyp surveillance and healthy individuals. Fisher’s exact and Spearman’s rank correlation tests were used for analysis. Propensity score matching adjusted for age, sex and comorbidities.Results 687 participants were eligible for analysis (NDBO n=306, DBO n=49, GORD n=132, colonic polyps n=152 and healthy n=48). 53% of NDBO participants reported similarly high cancer worry, comparable to DBO (50%, p=0.933) and colonic polyp participants (51%, p=0.355). Less cancer worry was reported in GORD participants (43.4%, p=0.01 vs NDBO). NDBO participants reported anxiety in 15.8% and depression in 8.6% of cases, which was similar to the other disease cohorts. Moderate or severe heartburn or acid regurgitation was found in 11% and 10%, respectively, in the NDBO cohort, comparable to DBO participants (heartburn 2% p=0.172, acid regurgitation 4% p=0.31) but lower (better) than GORD participants (heartburn 31% p=<0.001, acid regurgitation 25% p=0.001). NDBO participants with moderate or severe GORD symptoms were associated with higher rates of anxiety (p=<0.001), depression (p=<0.001) and cancer worry (p=<0.001). NDBO patients appropriately perceiving their cancer risk as low had lower rates of cancer worry (p=<0.001).Conclusion This study provides insight into the problems Barrett’s oesophagus patients may face. Future care pathways must be more patient focussed to address misconceptions of cancer risk, oesophageal cancer related worry and GORD symptom control.https://bmjopengastro.bmj.com/content/7/1/e000357.full |
| spellingShingle | John McLaughlin Yeng Ang James Britton Paraskevi Taxiarchi Glen Martin Robert Willert Maria Horne Shaheen Hamdy Comparative quantitative survey of patient experience in Barrett’s oesophagus and other gastrointestinal disorders BMJ Open Gastroenterology |
| title | Comparative quantitative survey of patient experience in Barrett’s oesophagus and other gastrointestinal disorders |
| title_full | Comparative quantitative survey of patient experience in Barrett’s oesophagus and other gastrointestinal disorders |
| title_fullStr | Comparative quantitative survey of patient experience in Barrett’s oesophagus and other gastrointestinal disorders |
| title_full_unstemmed | Comparative quantitative survey of patient experience in Barrett’s oesophagus and other gastrointestinal disorders |
| title_short | Comparative quantitative survey of patient experience in Barrett’s oesophagus and other gastrointestinal disorders |
| title_sort | comparative quantitative survey of patient experience in barrett s oesophagus and other gastrointestinal disorders |
| url | https://bmjopengastro.bmj.com/content/7/1/e000357.full |
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